The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model

Abstract

The crude extract of Jatropha isabellei and its fraction rich in alkaloid presents antinociceptive and anti-inflammatory effects in a rat gout model, similar to that observed after treatment with colchicine, supporting the traditional use of this plant in gouty patients.

Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice

“…126e127 C (ref. 24: 137e139 C); 1 H NMR (600 MHz, DMSO-d 6 ) d 7.89 (d,J ¼ 8.5,2H,Ar),7.64 (d,J ¼ 8.3,2H,Ar),7.56 (d,J ¼ 8.5,2H,Ar), 7.53 (s, 2H, NH 2 ), 7.30e7.26 (m, 3H, Ar þ H-4); 13 C NMR (100 MHz, DMSO-d 6 ) d 144.1 (C-5), 143.9 (Ar), 142.2 (q, J ¼ 37.9, C-3) 140.7,131.6,130.7,127.4,126.7,125.8,122.8 (Ar), 121.0 (q, J ¼ 268.7, CF 3 ) 106.4 (C-4); 19 F NMR (565 MHz, DMSO-d 6 ) d À60.9 (CF 3 ); IR Ѵ max (cm À1 ): 3354, 3274 (NH 2 ), 1596,1561,1496,1444,1345,1273,1229,1158,1133,1095,982,805,835,806; MS-EI (m/z): 445 (100, M þ ), 364 (29), 286 (27) Male Swiss mice (25e30 g) were kept in a temperaturecontrolled room (22 ± 2 C) under a 12 h lightedark cycle (lights on from 6:00 a.m. to 6 p.m.) with standard lab chow and tap water ad libitum. The animals were acclimatized to the laboratory for at least 2 h before the experiments and were used only once.…”

“…Edema formation was considered to be an increase in paw thickness (in mm), and it was measured before and 48 h after CFA injection, using a digital caliper [7b, [29]]. Paw edema was expressed as the variation in test paw thickness in comparison with the baseline measurement.…”

Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice

“…Medicinal plants have been used almost in all cultures as sources of medicine to treat, cure or prevent diseases (Melo et al, 2013;Silva et al, 2012). Most of these plants have been evaluated using experimental animal models (Al-Sayed and El-Naga, 2015;Silva et al, 2013) as well as in humans (Dapas et al, 2014) in order to confirm their activities.…”

“…Literature data shows that several plant extracts are commonly used for the treatment of painful and inflammatory conditions (Melo et al, 2013;Silva et al, 2012Silva et al, , 2013. Pain is one of the most prevalent conditions that limits productivity and reduces the quality of patient's life.…”

Anti-inflammatory and antinociceptive effect of Pachygone ovata leaves

“…The aqueous fraction was collected, alkalized using ammonium hydroxide and washed three times with ethyl ether. The ethereal fraction was allowed to dry, resulting in a purified alkaloid fraction (AF) (Silva et al 2013).…”