The antinociceptive and anti-inflammatory effects of hydro alcoholic extract of Satureja bachtiarica on mouse

Saghaei, F; Motamedi, Pezhman

doi:10.14196/jhd.2018.179

Cited by 1 publication

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“…2016), anticancer (Behdarvand Shoushtar and Ghasemi Pirbaloti 2017), neuroprotective (Soodi et al. 2012), anti-inflammatory and analgesic (Saghaei and Motamedi 2017) properties of S . bachtiarica extract.…”

Section: Introductionmentioning

confidence: 99%

“…S. bachtiarica is also recommended for the treatment of cough, dyspnoea, diarrhoea and stomach cramps (Khadivi-Khub et al 2015). Pharmacological studies have demonstrated antioxidant (Soodi et al 2016), anticancer (Behdarvand Shoushtar and Ghasemi Pirbaloti 2017), neuroprotective (Soodi et al 2012), anti-inflammatory and analgesic (Saghaei and Motamedi 2017) properties of S. bachtiarica extract. Therefore, this study investigates the efficacy of S. bachtiarica extract on STZ-induced hyperglycaemia, oxidative stress, tissue damage and expression of GLUT2 and GLUT4 receptors in diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

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The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress

Joudaki

Setorki

2019

Pharmaceutical Biology

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Context: Oxidative stress plays an important role in development of diabetes mellitus. Satureja bachtiarica Bunge (Lamiaceae) is a rich source of bioactive compounds with antioxidant properties. Objective: This study investigates the antidiabetic effect of hydroalcoholic extract of aerial parts of S. bachtiarica . Methods and materials: Male Wistar rats were randomly divided into six groups ( n = 8) including control (normal saline), diabetic [Streptozotocin (STZ)], intervention (STZ plus hydroalcoholic extract of S. bachtiarica at doses of 75, 150 and 250 mg/kg/d) and positive control (STZ plus captopril 50 mg/kg/d) groups. A single intraperitoneal (IP) injection of STZ (60 mg/kg) was used to induce diabetes and IP therapy with drugs was performed for four weeks. Results : In diabetic rats, serum total antioxidant capacity (TAC) decreased significantly, but glucose, alkaline phosphatase ( ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT) and malondialdehyde (MDA) increased significantly as compared to the control ( p < 0.05). Treatment with extract (250 mg/kg) caused a significant decline in serum glucose, GGT, ALT, AST and MDA as well as a significant increase in serum TAC ( p < 0.05). During the intervention period, diabetic rats showed significant weight loss, but extract (250 mg/kg) treated rats did not show any weight loss. Extract (250 mg/kg) up-regulated GLUT2 expression and down-regulated GLUT4 expression in the liver ( p < 0.05). S . bachtiarica extract at all dosage levels prevented STZ-induced histological damage of liver, kidney and pancreas. Discussion and conclusions: S . bachtiarica extract exhibits antidiabetic effects through modulation of oxidative stress and expression of GLUT2 and GLUT4 .

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Section: Introductionmentioning

confidence: 99%