The antineutrophil cytoplasmic antibody–associated vasculitides

Seo, Philip; Stone, John H.

doi:10.1016/j.amjmed.2004.02.030

Cited by 419 publications

(294 citation statements)

References 63 publications

Supporting

Mentioning

270

Contrasting

Unclassified

Order By: Relevance

“…In our series, we have found a positivity of the ANCA (generally anti-MPO pANCA) in 26% of cases which is slightly lower than in the other series [5,19,20]. The difference between clinical manifestations of o ur study and the others series like more heart manifestation can maybe explain this low rate of ANCA positivity [22].…”

contrasting

confidence: 51%

“…We have considered as a flare-up all new visceral attack related to Churg-Strauss vasculitis hitherto latent or asymptomatic as well as any known visceral attack requiring a rise of the corticosteroid therapy strictly of more than 50% or the addition of an immunosuppressive treatment. The FFS (Five Factor Score) evaluating the vasculitides prognostic at ANCA (Anti-cytoplasm antibodies of polynuclear neutrophils) 6 [3] has been calculated during a diagnosis and compared to the initial treatment received by the patients and to the therapeutic recommendations based on this score [4][5][6][7]. The remission rate (free from flare-up for over 6 months) to a one-year treatment has also been counted.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Churg–Strauss syndrome: retrospective study in Burgundian population in France in past 10 years

Vinit¹,

Müller²,

Bielefeld³

et al. 2009

Rheumatol Int

View full text Add to dashboard Cite

contrasting

confidence: 51%

mentioning

confidence: 99%

Churg–Strauss syndrome: retrospective study in Burgundian population in France in past 10 years

Vinit¹,

Müller²,

Bielefeld³

et al. 2009

Rheumatol Int

View full text Add to dashboard Cite

“…Together with other conditions associated with ANCA with specificity to MPO, proteinase 3 (PR3) or other antigens, MPA constitutes a condition collectively called ANCA-associated vasculitis (AAV). 1 Although the etiology of AAV is poorly understood, substantial difference in the incidence among populations 2 and sporadic reports of multiplex families 3 suggest a role of genetic predisposition. With respect to MPO-ANCA associated vasculitis, previous studies reported association of HLA [4][5][6] and non-HLA genes, 7-10 although many of them have not been confirmed by independent studies.…”

Section: Introductionmentioning

confidence: 99%

Association of HLA-DRB10901-DQB10303 haplotype with microscopic polyangiitis in Japanese

et al. 2005

View full text Add to dashboard Cite

Microscopic polyangiitis (MPA) is a rare and severe form of systemic necrotizing vasculitis associated with myeloperoxidase (MPO)-specific antineutrophil cytoplasmic antibody (ANCA). We previously reported significant association of HLA-DRB1*0901 with MPA. To define the susceptibility loci within the HLA region, we determined the genotypes of HLA-DQB1, DPB1, B and C in 50 patients with MPA and 77 unrelated Japanese controls. In addition to HLA-DRB1*0901, significant association of DQB1*0303 (allele carrier frequencies 50% in MPA, 29.9% in controls, odds ratio 2.35, P ¼ 0.017) was detected. These alleles were in strong linkage disequilibrium (D 0 ¼ 0.95, r 2 ¼ 0.82). Increased frequency was also observed for DPB1*0201, B*15111 and Cw*0303, which was at least partly accounted for by linkage disequilibrium with DRB1*0901 and DQB1*0303. These results indicate that DRB1*0901-DQB1*0303 haplotype represents the primary genetic risk for MPA within the HLA region in Japanese, and provides the basis that future functional studies on the role of HLA in MPA should target DR9, DQ9 and DR53 proteins encoded by this haplotype.

show abstract

“…The other types of systemic vasculitis that are often associated with vasculitic neuropathy are those that are commonly associated with ANCAs: Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome (15). Among these 3 disorders, peripheral nerve involvement is more common in both Churg-Strauss syndrome and microscopic polyangiitis, but devastating peripheral neuropathy can occur in Wegener's granulomatosis as well.…”

Section: Primary Systemic Vasculitidesmentioning

confidence: 99%

“…After these symptoms had been present for several weeks, the patient established care with a primary care physician. At his first appointment his erythrocyte sedimentation rate (ESR) was 42 mm/hour (normal range [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. An assay for antinuclear antibodies (ANA) was positive at a titer of 1:160 (speckled), but antibodies to double-stranded DNA and to extractable nuclear antigens (Ro, La, Sm, and RNP) were negative.…”

mentioning

confidence: 99%

A 36‐year‐old man with paresthesias and a headache

Castelino

Wasfy

Collier

2008

Arthritis & Rheumatism

View full text Add to dashboard Cite

History of the present illnessA 36-year-old man with a history of non-Hodgkin's lymphoma was admitted to the hospital with paresthesias and a headache. His paresthesias began 5 months prior to admission, when he developed left leg numbness and pain, accompanied by an erythematous rash that he described as "splotchy." The rash appeared initially on the patient's left leg, but then expanded to include his torso and upper extremities. The rash, numbness, and pain all resolved without intervention after 1 week. Three months prior to admission, he experienced recurrent numbness in the left leg that again resolved spontaneously after several days.Two months prior to admission, the patient's symptoms intensified. He developed bilateral numbness and tingling, first in both feet and then in both hands. He noted that grasping objects with his hands caused a burning sensation in his palms, and he experienced pain and swelling in his left foot and ankle. After these symptoms had been present for several weeks, the patient established care with a primary care physician. At his first appointment his erythrocyte sedimentation rate (ESR) was 42 mm/hour (normal range 1-20). An assay for antinuclear antibodies (ANA) was positive at a titer of 1:160 (speckled), but antibodies to double-stranded DNA and to extractable nuclear antigens (Ro, La, Sm, and RNP) were negative. The laboratory results are shown in Table 1.One month before admission, the patient developed "unbearable" pain in his feet and noted that his socks felt too tight. He reported tingling in his hands, nausea, and daily emesis. The patient was referred for nerve conduction velocity and electromyography of the lower and upper extremities. These investigations revealed a symmetric sensory polyneuropathy that predominantly involved the lower extremities. The patient was prescribed gabapentin (200 mg 3 times daily), but his symptoms persisted. Three days prior to admission, the patient developed a severe occipital headache that did not remit despite use of ibuprofen (600 mg 3 times daily).On the morning of admission, the patient presented to his primary care doctor reporting a severe headache (rated as 10/10), profound fatigue, and numbness, pain, and weakness in both feet. His blood pressure was 168/119 mm Hg in the right arm and 175/123 mm Hg in the left arm. He was referred to the emergency department for hypertensive urgency. Past medical historyThe patient's non-Hodgkin's lymphoma was diagnosed at age 16 years. He had been treated with a standard chemotherapy regimen for 6 cycles (CHOP: cyclophosphamide, hydroxydaunomycin [doxorubicin], vincristine, and prednisone). This treatment was presumed to have resulted in a cure. The patient was also diagnosed with iron deficiency anemia several years before admission. An esophagogastroduodenoscopy at that time was normal. Family and social historyThe patient's family history was remarkable for the fact that his father had multiple strokes before the age of 40 years. In addition, the patient reported many relatives on both p...

show abstract

The antineutrophil cytoplasmic antibody–associated vasculitides

Cited by 419 publications

References 63 publications

Churg–Strauss syndrome: retrospective study in Burgundian population in France in past 10 years

Churg–Strauss syndrome: retrospective study in Burgundian population in France in past 10 years

Association of HLA-DRB10901-DQB10303 haplotype with microscopic polyangiitis in Japanese

A 36‐year‐old man with paresthesias and a headache

Contact Info

Product

Resources

About

The antineutrophil cytoplasmic antibody–associated vasculitides

Cited by 419 publications

References 63 publications

Churg–Strauss syndrome: retrospective study in Burgundian population in France in past 10 years

Churg–Strauss syndrome: retrospective study in Burgundian population in France in past 10 years

Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese

A 36‐year‐old man with paresthesias and a headache

Contact Info

Product

Resources

About

Association of HLA-DRB10901-DQB10303 haplotype with microscopic polyangiitis in Japanese