The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay

Evandri, Maria Grazia; Battinelli, Lucia; Daniele, C.; Mastrangelo, Sabina; Bolle, P.; Mazzanti, Gabriela

doi:10.1016/j.fct.2005.03.013

Cited by 138 publications

(101 citation statements)

References 36 publications

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“…Lavender oil has shown strong antimutagenic activity, as oils from L. angustifolia exhibited a significant, concentration-dependent reduction in the mutagenic activity of TA98 bacterial strains exposed to the potent mutagen 2-nitrofluorene [39]. Although weak as compared to other essential oils, lavender oils exerted suppression of tumor necrosis factor alphainduced neutrophil adherence responses [40].…”

Section: Studies In Model Speciesmentioning

confidence: 99%

“…Although weak as compared to other essential oils, lavender oils exerted suppression of tumor necrosis factor alphainduced neutrophil adherence responses [40]. The antimutagenic properties of lavender make it a promising candidate for new applications in human healthcare, potentially as a topological application to protect skin cancer [39]. Using such models, researchers can identify the action of specific lavender terpenoids in vivo.…”

Section: Studies In Model Speciesmentioning

confidence: 99%

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Biosynthesis and Therapeutic Properties ofLavandulaEssential Oil Constituents

Woronuk

Demissie²,

Rheault³

et al. 2010

Planta Med

179

122

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Section: Studies In Model Speciesmentioning

confidence: 99%

Section: Studies In Model Speciesmentioning

confidence: 99%

Biosynthesis and Therapeutic Properties ofLavandulaEssential Oil Constituents

Woronuk

Demissie²,

Rheault³

et al. 2010

Planta Med

179

122

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“…The commonly used EOs from Melaleuca alternifolia (tea -tree oil) and Lavandula angustifolia (lavender oil) show antimicrobial activity and are able to treat minor health problems. Evandri et al [57] investigated their mutagenic and antimutagenic activities using the bacterial reverse mutation assay in Salmonella typhimurium TA98 and TA100 strains and in Escherichia coli WP2 uvrA strain. They did so with and without an extrinsic metabolic activation system.…”

Section: Mutagenicity Anti-mutagenicity and Dna-protective Effectsmentioning

confidence: 99%

Cytotoxic, anti-carcinogenic and antioxidant properties of the most frequent plant volatiles

Slameñová¹,

Horváthová²

2013

neo

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Flowers, berries, leaves, barks and roots of different plants have been used through the ages as a source of flavor in food and perfume preparations. The volatiles responsible for the flavor of botanicals can be extracted from the plant material as "essential oils" (EOs), called also volatile oils or ethereal oils. The term essential is intended to indicate that the oil is the fragrant essence of the plant from which it is extracted. EOs are constituted by hydrocarbons (monoterpenes and sesquiterpenes) and oxygenated compounds (alcohols, esters, ethers, aldehydes, ketones, lactones, phenols and phenol ethers). Of the numerous groups of naturally occurring compounds examined so far terpenes are known as fragrances and flavoring agents. The data reported in this review including the data obtained in our laboratory show that many of EOs exhibit a range of biological activities inclusive of antioxidative, anti-mutagenic and anti-carcinogenic activities. Most of them belong to phytochemicals with chemopreventive potential. On the other hand some herbal products can cause serious adverse effects. A complex research of toxic, genotoxic, anti-mutagenic and anti-carcinogenic effects of EOs is therefore very important.

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“…lavender, sage, Teucrium ramosissimum, origanum compactum and rose essential oils (Evandri et al 2005;Knezevic et al 2005;Mezzoug et al 2007;Sghaier et al 2010;Agabeyli and Mirzazadeh 2011). As mentioned before the addition of rose concrete oils showed some improvement in the frequency of chromosomal aberrations which is less than for rose absolute oil.…”

Section: Gc-ms Analysismentioning

confidence: 99%

Cytogenetic, cytotoxic and GC–MS studies on concrete and absolute oils from Taif rose, Saudi Arabia

et al. 2013

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Taif rose (Rosa damascena trigintipetala Dieck) is a sort of damask rose, which is considered as one of the most important economic products of Taif. In this study, the authors investigated the possible cytotoxic, genotoxic, antimutagenic and anticancer effect of concrete and absolute rose oils. The results showed that both concrete and absolute rose oils were cytotoxically and genotoxically safe at a dose of 10 lg/ml when tested on cultures of normal human blood lymphocytes. Also, the results showed significant antimutagenic activity at p \ 0.001 for absolute rose oil at the same dose level when tested on cultures of normal human blood lymphocytes supplemented with 300 ng/ml mitomycin C (MMC). On the other hand, concrete and absolute oils exerted a cytotoxic activity against two kinds of human cancer cell lines: HepG2 and MCF7. Concrete oil showed cytotoxic activity against HepG2 and MCF7 with a half maximal inhibitory concentration (IC 50 ) of 16.28 and 18.09 lg/ml, respectively, whereas absolute rose oil showed its cytotoxic activity against HepG2 and MCF7 with an IC 50 of 24.94 and 19.69, respectively. From this study, it is concluded that concrete and absolute rose oils are cytotoxically and genotoxically safe at a dose of 10 lg/ml when tested on cultures of normal human blood lymphocytes. In addition, absolute oil has an antimutagenic activity at the same dose. Further investigations are needed to study the activity of higher doses of both oils in vitro and in vivo in experimental animals in order to evaluate the capability of using these oils as therapeutic for treatment of some kinds of cancers.

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The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay

Cited by 138 publications

References 36 publications

Biosynthesis and Therapeutic Properties ofLavandulaEssential Oil Constituents

Biosynthesis and Therapeutic Properties ofLavandulaEssential Oil Constituents

Cytotoxic, anti-carcinogenic and antioxidant properties of the most frequent plant volatiles

Cytogenetic, cytotoxic and GC–MS studies on concrete and absolute oils from Taif rose, Saudi Arabia

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