The antimicrobial properties, cytotoxicity, and differentiation potential of double antibiotic intracanal medicaments loaded into hydrogel system

Abstract

The methylcellulose-based hydrogel proposed in this study can be used clinically as a biocompatible system to deliver controlled low concentrations of DAP.

Optimal antimicrobial concentration of mixed antibiotic pastes in eliminating Enterococcus faecalis from root dentin

“…However, another study reported that propylene glycol did not alter the penetration of the medicament it was used to deliver (29). Currently, different drug carriers, such as chitosan and methylcellulose hydrogel, are being tested to improve the efficacy of antimicrobials used as intracanal medicaments (30,31).…”

Effects of radiopaque double antibiotic pastes on the proliferation, alkaline phosphatase activity and mineral deposition of dental pulp stem cells

“…In addition, they lack the ability to be traced radiographically once they are administered within the root canal system. The biological effects of methylcellulose-based DAP have been considerably explored in a recent published study (McIntyre et al, 2019). However, no previous studies have explored the biological effects of incorporating radiopaque components into an antibioticbased intracanal medicament tailored for REP.…”

“…This recommendation is based on multiple in vitro studies suggesting that higher concentrations of antibiotic combinations are cytotoxic to dental pulp stem cells (DPSCs) (Chuensombat, Khemaleelakul, Chattipakorn, & Srisuwan, 2013) and SCAP (Ruparel, Teixeira, Ferraz, & Diogenes, 2012). Recent antibacterial studies have demonstrated that 1-5 mg/mL of triple antibiotic paste (TAP) (Arruda et al, 2018) or double antibiotic paste (DAP) (Jenks, Ehrlich, Spolnik, Gregory, & Yassen, 2016;McIntyre et al, 2019) have superior antimicrobial properties than Ca(OH)2.…”

Tratar ou extrair? Tratamento de lesão endoperiodontal, um relato de caso clínico

“…O hidróxido de cálcio é o medicamento mais usado como medicação intracanal na endodontia 3,14,15 por possuir várias características adequadas 16 : é biocompatível 14,17 , tem capacidade de elevação do pH do meio, colaborando com a alcanilização das áreas de reabsorção 16 e de auxiliar na indução da formação de tecido mineralizado 13,14 , atua sobre vários microrganismos, inativando a endotoxina liberada pelas bactérias gram negativas, ou seja, possui ação antimicrobiana 14,[18][19][20] , tem propriedade de difusão no sistema de canais radiculares 14,21 e promove o reparo apical e periapical [21][22][23] .…”