The antimicrobial potential of algicolous marine fungi for counteracting multidrug-resistant bacteria: phylogenetic diversity and chemical profiling

Esposito, Fortunato Palma; Festa, Carmen; Poli, A.; Tedesco, Pietro; Fani, Renato; Monti, Maria Chiara; Pascale, Donatella de; D’Auria, Maria Valeria; Varese, Giovanna Cristina

doi:10.1016/j.resmic.2016.04.009

Cited by 15 publications

(22 citation statements)

References 44 publications

(42 reference statements)

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“…bassiana (MUT 4865), K . petricola (MUT 4979) produce antimicrobial compounds effective against Multi Drug Resistant Bacteria [80]; ii) Roussoellaceae sp. 2 (MUT 4859), A .…”

Section: Discussionmentioning

confidence: 99%

The culturable mycobiota of Flabellia petiolata: First survey of marine fungi associated to a Mediterranean green alga

et al. 2017

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Algae-inhabiting marine fungi represent a taxonomically and ecologically interesting group of microorganisms still largely neglected, especially in temperate regions. The aim of this study was to isolate and to identify the culturable mycobiota associated with Flabellia petiolata, a green alga frequently retrieved in the Mediterranean basin. Twenty algal thalli were collected from two different sampling sites in the Mediterranean Sea (Elba Island, Italy). A polyphasic approach showed the presence of a relevant alga-associated mycobiota with 64 taxa identified. The fungal isolates belonged mainly to Ascomycota (61 taxa), while only three Basidiomycota were detected. The phylogenetic position of sterile mycelia and cryptic taxa, inferred on the basis of LSU partial region, highlighted the presence of putative new phylogenetic lineages within Dothideomycetes and Sordariomycetes. This work represents the first quali-quantitative analysis of the culturable mycobiota associated to a green alga in the Mediterranean Sea.

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“…bassiana (MUT 4865), K . petricola (MUT 4979) produce antimicrobial compounds effective against Multi Drug Resistant Bacteria [80]; ii) Roussoellaceae sp. 2 (MUT 4859), A .…”

Section: Discussionmentioning

confidence: 99%

The culturable mycobiota of Flabellia petiolata: First survey of marine fungi associated to a Mediterranean green alga

et al. 2017

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“…Alternaria alternata isolated from soft coral Denderonephthya hemprichi produced pyrophen and rubrofusarin has antimicrobial activity against Candida albicans (Shaaban, Shaaban, & Abdel-Aziz, 2012). The crude extract of Knufia petricola origin from green alga Flabellia petiolata showed antibacterial act iv iti es against Burkholder metallica and Staphylococcus aureus (Gnavi et al, 2016). Marine Fusarium isolated from Indian seawater showed the amylase activity (Lanka, Pydipally, & Latha, 2016).…”

Section: Shared Species Phylogenetic Tree Of Fungal Communities Assocmentioning

confidence: 99%

“…Several studies about fungi associated with algae have been conducted which most of them used culture dependent techniques (Gnavi et al, 2016;Loque et al, 2010;Godinho et al, 2013). The results showed that culture dependent technique only revealed less than 1% of fungal community (Handelsman, 2005).…”

Section: Introductionmentioning

confidence: 99%

Fungal Community Structure of Macroalga Ulva Intestinalis Revealed by Miseq Sequencing

Agusman

Feng

2017

Squalen Bull. Marine Fisheries Postharvest Biotech.

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Since algae are well known as the host of fungi, the information about total fungal community associated with alga is needed to give the initial data that is useful for natural product discovery. The study on total fungal community associated with marine macroalga U. intestinalis from Xiamen-China was carried out using MiSeq, a powerful platform for microbial ecology studies. Metagenomics DNA was isolated from surfaces of the U. intestinalis thallus and rocks colonized by this alga and 18S ribosomal RNA region was sequenced using MiSeq Illumina to yield 81360 sequences from 162720 reads, which average read length is 245.61 bp. The sequences were assigned to operational taxonomic units (OTUs), where 101 genera represent 5 phyla, 17 classes and 64 families of fungal. Ascomycota was the highest abundance share of fungal community at phylum level. Meanwhile Aspergillus, Blastobotrys, Alternaria, Knufia, and Fusarium were some of dominant genera found associated with U. intestinalis which have been reported as the promising source of natural products. By using MiSeq platform, this study revealed the total community structure of algicolous fungi associated with U. intestinalis.

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“…Other serious drug-resistant pathogens deliberately not included in the priority list are multidrug-resistant (MDR) or extensively drug-resistant (EDR) Mycobacterium tuberculosis, P. falciparum malaria, MDR Candida species (resistant to fluconazole, echinocandin, and amphotericin B), etc. This is because some of these pathogens such as M. tuberculosis are already a globally established priority for which innovative new treatments are also urgently needed [5,6]. Table 1.…”

Section: Introductionmentioning

confidence: 99%

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

et al. 2020

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As the search for new antibiotics continues, the resistance to known antimicrobial compounds continues to increase. Many researchers around the world, in response to antibiotics resistance, have continued to search for new antimicrobial compounds in different ecological niches such as the marine environment. Marine habitats are one of the known and promising sources for bioactive compounds with antimicrobial potentials against currently drug-resistant strains of pathogenic microorganisms. For more than a decade, numerous antimicrobial compounds have been discovered from marine environments, with many more antimicrobials still being discovered every year. So far, only very few compounds are in preclinical and clinical trials. Research in marine natural products has resulted in the isolation and identification of numerous diverse and novel chemical compounds with potency against even drug-resistant pathogens. Some of these compounds, which mainly came from marine bacteria and fungi, have been classified into alkaloids, lactones, phenols, quinones, tannins, terpenes, glycosides, halogenated, polyketides, xanthones, macrocycles, peptides, and fatty acids. All these are geared towards discovering and isolating unique compounds with therapeutic potential, especially against multidrug-resistant pathogenic microorganisms. In this review, we tried to summarize published articles from 2015 to 2019 on antimicrobial compounds isolated from marine sources, including some of their chemical structures and tests performed against drug-resistant pathogens.

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The antimicrobial potential of algicolous marine fungi for counteracting multidrug-resistant bacteria: phylogenetic diversity and chemical profiling

Cited by 15 publications

References 44 publications

The culturable mycobiota of Flabellia petiolata: First survey of marine fungi associated to a Mediterranean green alga

The culturable mycobiota of Flabellia petiolata: First survey of marine fungi associated to a Mediterranean green alga

Fungal Community Structure of Macroalga Ulva Intestinalis Revealed by Miseq Sequencing

Antibiotics Development and the Potentials of Marine-Derived Compounds to Stem the Tide of Multidrug-Resistant Pathogenic Bacteria, Fungi, and Protozoa

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