The antimicrobial efficacy of Fructus mume extract on orthodontic bracket: A monospecies-biofilm model study in vitro

Abstract

Fructus mume extract showed antimicrobial effect on S. mutans biofilm on orthodontic bracket in vitro which may indicate its potential use as an oral antimicrobial agent for orthodontic patients.

Inhibition ofKlebsiella pneumoniaeGrowth and Capsular Polysaccharide Biosynthesis byFructus mume

“…Although the acidic components of Prunus mume showed some antibacterial activity, it is less compared to that of the original extract, implying that other active components possess considerable antibacterial activity [36]. As seen in Figure 6, we also showed that citric acid could inhibit growth and CPS production in K. pneumoniae .…”

“…The emergence of carbapenem-resistant enterobacteria is worrisome because the option for antimicrobial treatment is further restricted. In this study, we screened a series of TCMs for the identification of new antibacterial agents (data not shown) and then focused on Fructus mume , the smoked fruit of Prunus mume, which has been demonstrated to efficiently inhibit H. pylori and other oral bacteria [33–36]. As shown in Figure 1, Fructus mume extract was found to have antibacterial activity against clinically isolated K. pneumoniae strains.…”

“…The ingredients of Prunus mume extract are organic acids, including citric acid (the main ingredient), tartaric acid, oxalic acid, and other unknown components [35, 36]. Although the acidic components of Prunus mume showed some antibacterial activity, it is less compared to that of the original extract, implying that other active components possess considerable antibacterial activity [36].…”

“…Prunus mume extract has also been shown to inhibit Helicobacter pylori infection, which is associated with gastritis and gastric ulcers [33]. In addition, Fructus mume extract is a potential candidate for developing an oral antimicrobial agent to control or prevent dental diseases associated with several oral pathogenic bacteria [34–36]. A study involving high-pressure liquid chromatography (HPLC) analysis has also demonstrated that citric acid is the main organic acid in Fructus mume extract [35, 36].…”

The effects of natural compounds‐containing mouthrinses on patients with fixed orthodontic appliance treatment: clinical and microbiological outcomes

“…Thus, this water‐soluble natural extract is likely to be used as a nonalcohol‐containing NCCM in the management of gingivitis. As high‐performance liquid chromatography (HPLC) data have shown that the main ingredients of FM extract are organic acids that include citric acid, tartaric acid, oxalic acid, etc ,. we developed a two‐stage mouthrinse whereby the second‐stage sodium bicarbonate solution was used to neutralize residual of the first‐stage acidic FM solution.…”