The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens

Yim, Nam–Hui; Ha, Do Thi; Trung, Trân Nam; Kim, Jin Pyo; Lee, Sang-Myung; Na, MinKyeun; Jung, Hyun‐Ju; Kim, Hyun Su; Kim, Young Ho; Bae, KiHwan

doi:10.1016/j.bmcl.2009.12.020

Cited by 62 publications

(32 citation statements)

References 19 publications

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“…A previous study by Yim et al [24] reported that trans -ε-viniferin from Vitis amurensis displayed the strongest activity against S. mutans and S. sanguis hence, this implies that this resveratrol dimer is active against mostly Gram-positive bacteria. Our finding showed that α-viniferin is a stronger anti-MRSA agent compared to ε-viniferin.…”

Section: Resultsmentioning

confidence: 90%

Evaluation of the Combined Effects of Stilbenoid from Shorea gibbosa and Vancomycin against Methicillin-Resistant Staphylococcus aureus (MRSA)

et al. 2012

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The aim of this study is to determine the combined effects of stilbenoids from Shorea gibbosa and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA). A total of nine pure compounds, five stilbenoid dimers ε-viniferin, ampelopsin A, balanocarpol, laevifonol and diptoindonesin G and four stilbenoid trimers α-viniferin, johorenol A, ampelopsin E and vaticanol G were evaluated for their antibacterial activities against ATCC 33591 and a HUKM clinical isolate. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for each active compound were determined using the serial microdilution and plate-streak techniques. The combined effect of stilbenoids with vancomycin against MRSA was evaluated using the checkerboard assay to determine their fractional inhibitory concentration (FIC) index values. The MIC value of α-viniferin on both MRSA strains was 100 μg/mL, whereas those of johorenol A on ATCC 33591 and HUKM strain were 100 μg/mL and 200 μg/mL, respectively. The MIC values of ampelopsin E and vaticanol G were higher than 400 μg/mL. Out of the five stilbenoid dimers, only ε-viniferin was capable of inhibiting the growth of both MRSA strains at MIC 400 μg/mL. The MBC value of ε-viniferin, α-viniferin and johorenol A showed bacteriostatic action against MRSA. The FIC index value of ε-viniferin and α-viniferin in combination with vancomycin showed an additive effect (0.5 < FIC ≤ 2.0) against both MRSA strains. Johorenol A-vancomycin combination was also additive against HUKM strain, but it showed synergistic interaction with vancomycin against ATCC 33591 (FIC < 0.5). Stilbenoid compounds from Shorea gibbosa have anti-MRSA activity and huge potential as an alternative phytotherapy in combating MRSA infections.

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Section: Resultsmentioning

confidence: 90%

Evaluation of the Combined Effects of Stilbenoid from Shorea gibbosa and Vancomycin against Methicillin-Resistant Staphylococcus aureus (MRSA)

et al. 2012

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“…It has been identified as a potential antifungal [237], antitumor [238], antibacterial [239], antidiabetic [240], neuroprotective [241] and cardioprotective [242] agent. Viniferin exists in nature in different isoforms such as α-viniferin, β-viniferin, γ-viniferin, δ-viniferin and ε-viniferin [243].…”

Section: Pkc Modulation By Polyphenolsmentioning

confidence: 99%

Polyphenol compounds and PKC signaling

Das

Ramani

Suraju

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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Background Naturally occurring polyphenols found in food sources provide huge health benefits. Several polyphenolic compounds are implicated in the prevention of disease states, such as cancer. One of the mechanisms by which polyphenols exert their biological actions is by interfering in the protein kinase C (PKC) signaling pathways. PKC belongs to a superfamily of serine-threonine kinase and are primarily involved in phosphorylation of target proteins controlling activation and inhibition of many cellular processes directly or indirectly. Scope of review Despite the availability of substantial literature data on polyphenols' regulation of PKC, no comprehensive review article is currently available on this subject. This article reviews PKC-polyphenol interactions and its relevance to various disease states. In particular, salient features of polyphenols, PKC, interactions of naturally occurring polyphenols with PKC, and future perspective of research on this subject are discussed. Major conclusions Some polyphenols exert their antioxidant properties by regulating the transcription of the antioxidant enzyme genes through PKC signaling. Regulation of PKC by polyphenols is isoform dependent. The activation or inhibition of PKC by polyphenols has been found to be dependent on the presence of membrane, Ca2+ ion, cofactors, cell and tissue types etc. Two polyphenols, curcumin and resveratrol are in clinical trials for the treatment of colon cancer. General significance The fact that 74% of the cancer drugs are derived from natural sources, naturally occurring polyphenols or its simple analogs with improved bioavailability may have the potential to be cancer drugs in the future.

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“…Recently, the root and stem of V. amurensis have been reported to possess anti-inflammatory and anti-tumor activities and neuroprotective effect against β-amyloid-induced oxidative stress in cell cultures (Huang et al, 2001;Lee et al, 2006;Jang et al, 2007) and to contain a wide variety of structurally diverse resveratrol oligomers (Huang et al, 2000(Huang et al, , 2001. Studies on the chemical substances and pharmacological activities of the leaf and stem of V. amurensis have isolated eleven resveratrols, including stilbenes and oligostilbenes, which have antioxidant and antiinflammatory effects and cytotoxic activity when assayed using cancer cell lines in vitro (Ha et al, 2009a(Ha et al, , 2009bYim et al, 2010). Since oxidative stress has been shown to precede the formation of senile plaques (Petersen et al, 2007) and inflammatory responses may significantly contribute to the progression of AD (Heneka and O'Banion, 2007), free radical scavengers and anti-inflammatory agents have attracted considerable attention as potential neuroprotective agents in AD.…”

Section: Introductionmentioning

confidence: 99%

Leaf and stem of Vitis amurensis and its active components protect against amyloid β protein (25–35)-induced neurotoxicity

et al. 2010

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This study investigated a methanol extract from the leaf and stem of Vitis amurensis (Vitaceae) for possible neuroprotective effects on neurotoxicity induced by amyloid β protein (Aβ) (25-35) in cultured rat cortical neurons and also for antidementia activity in mice. Exposure of cultured cortical neurons to 10 μM Aβ (25-35) for 36 h induced neuronal apoptotic death. At concentrations of 1-10 μg/mL, V. amurensis inhibited neuronal death, the elevation of intracellular calcium ([Ca(2+)](i)) and the generation of reactive oxygen species (ROS), all of which were induced by Aβ (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of ICR mice with 16 nmol Aβ (25-35) was inhibited by chronic treatment with V. amurensis extract (50 and 100 mg/kg, p.o. for 7 days), as measured by a passive avoidance test. Amurensin G, r-2-viniferin and trans-ɛ-viniferin isolated from V. amurensis also inhibited neuronal death, the elevation of [Ca(2+)](i) and the generation of ROS induced by Aβ (25-35) in cultured rat cortical neurons. These results suggest that the neuroprotective effect of V. amurensis may be partially attributable to these compounds. These results suggest that the antidementia effect of V. amurensis is due to its neuroprotective effect against Aβ (25-35)-induced neurotoxicity and that the leaf and stem of V. amurensis have possible therapeutic roles for preventing the progression of Alzheimer's disease.

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The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens

Cited by 62 publications

References 19 publications

Evaluation of the Combined Effects of Stilbenoid from Shorea gibbosa and Vancomycin against Methicillin-Resistant Staphylococcus aureus (MRSA)

Evaluation of the Combined Effects of Stilbenoid from Shorea gibbosa and Vancomycin against Methicillin-Resistant Staphylococcus aureus (MRSA)

Polyphenol compounds and PKC signaling

Leaf and stem of Vitis amurensis and its active components protect against amyloid β protein (25–35)-induced neurotoxicity

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