The Antimalarial Activity ofSpathodea campanulataStem Bark Extract onPlasmodium berghei bergheiin Mice

Abstract

The action of extracts of the stem bark of Spathodea campanulata on Pla.smodium berghei berghei in mice has been studied. The blood schizontocidal activity of the extracts was studied in early and established infections using chloroquine as the reference drug. The prophylactic action of the extracts was also investigated with pyrimethamine as the standard drug. The hexane and chloroform extracts of the stem bark showed blood schizontocidal action in both the 4-Day test and Rane test. The chloroform extract demonstrated some prophylactic properties while the aqueous extract did not show any significant antimalarial property. tion of the leaves, the action of the stem bark extracts of the plant was therefore investigated.

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