The Antihistamine Action of Ascorbic Acid

Johnston, Carol S.

doi:10.1007/978-1-4613-0325-1_10

Cited by 22 publications

(12 citation statements)

References 133 publications

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“…Although cold duration was impacted by vitamin C supplementation in the present trial, vitamin C did not reduce cold symptom severity as has been reported in the systematic reviews. Both the antioxidant and antihistamine properties of vitamin C have been implicated in cold symptom relief since oxidative stress and histamine contribute to cold severity [39,40]. Interestingly, histamine and vitamin C concentrations were correlated with cold symptom severity during the eight-week trial; however, vitamin C supplementation did not alter circulating histamine levels in this sample.…”

Section: Discussionmentioning

confidence: 92%

Vitamin C Supplementation Slightly Improves Physical Activity Levels and Reduces Cold Incidence in Men with Marginal Vitamin C Status: A Randomized Controlled Trial

Johnston

Barkyoumb²,

Schumacher

2014

Nutrients

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The early indications of vitamin C deficiency are unremarkable (fatigue, malaise, depression) and may manifest as a reduced desire to be physically active; moreover, hypovitaminosis C may be associated with increased cold duration and severity. This study examined the impact of vitamin C on physical activity and respiratory tract infections during the peak of the cold season. Healthy non-smoking adult men (18–35 years; BMI < 34 kg/m2; plasma vitamin C < 45 µmol/L) received either 1000 mg of vitamin C daily (n = 15) or placebo (n = 13) in a randomized, double-blind, eight-week trial. All participants completed the Wisconsin Upper Respiratory Symptom Survey-21 daily and the Godin Leisure-Time Exercise Questionnaire weekly. In the final two weeks of the trial, the physical activity score rose modestly for the vitamin C group vs. placebo after adjusting for baseline values: +39.6% (95% CI [−4.5,83.7]; p = 0.10). The number of participants reporting cold episodes was 7 and 11 for the vitamin C and placebo groups respectively during the eight-week trial (RR = 0.55; 95% CI [0.33,0.94]; p = 0.04) and cold duration was reduced 59% in the vitamin C versus placebo groups (−3.2 days; 95% CI [−7.0,0.6]; p = 0.06). These data suggest measurable health advantages associated with vitamin C supplementation in a population with adequate-to-low vitamin C status.

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Section: Discussionmentioning

confidence: 92%

Vitamin C Supplementation Slightly Improves Physical Activity Levels and Reduces Cold Incidence in Men with Marginal Vitamin C Status: A Randomized Controlled Trial

Johnston

Barkyoumb²,

Schumacher

2014

Nutrients

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“…Diamine oxidase (DAO) is the main enzyme for the metabolism of histamine. Supplementation of this enzyme or related cofactors like vitamin B6, copper and vitamin C, which are thought to support histamine degradation, 28 have been discussed in this respect. 29 From our results, we are unable to exactly define the origin of histamine found in the colonic wall.…”

Section: Discussionmentioning

confidence: 99%

Allergic Predisposition, Histamine and Histamine Receptor Expression (H1R, H2R) Are Associated with Complicated Courses of Sigmoid Diverticulitis

Rahden

Jurowich

Kircher

et al. 2012

Journal of Gastrointestinal Surgery

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“…A histamine‐free diet can be complemented with adjuvant administration of antihistamine receptor drugs. In addition, histamine degradation can be supported by the administration of vitamin C and B‐6, which may increase DAO activity . The use of drugs that interfere with histamine metabolism should be avoided.…”

Section: The Role Of Histamine In Inflammatory Disorders Of the Gutmentioning

confidence: 99%

Histamine and gut mucosal immune regulation

Smolińska

Jutel

Crameri

et al. 2013

Allergy

151

104

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Histamine is a biogenic amine with extensive effects on many cell types, mediated by the activation of its four receptors (H1R-H4R). Distinct effects are dependent on receptor subtypes and their differential expression. Within the gastrointestinal tract, histamine is present at relatively high concentrations, particularly during inflammatory responses. In this review, we discuss the immunoregulatory influence of histamine on a number of gastrointestinal disorders, including food allergy, scombroid food poisoning, histamine intolerance, irritable bowel syndrome, and inflammatory bowel disease. It is clear that the effects of histamine on mucosal immune homeostasis are dependent on expression and activity of the four currently known histamine receptors; however, the relative

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The Antihistamine Action of Ascorbic Acid

Cited by 22 publications

References 133 publications

Vitamin C Supplementation Slightly Improves Physical Activity Levels and Reduces Cold Incidence in Men with Marginal Vitamin C Status: A Randomized Controlled Trial

Vitamin C Supplementation Slightly Improves Physical Activity Levels and Reduces Cold Incidence in Men with Marginal Vitamin C Status: A Randomized Controlled Trial

Allergic Predisposition, Histamine and Histamine Receptor Expression (H1R, H2R) Are Associated with Complicated Courses of Sigmoid Diverticulitis

Histamine and gut mucosal immune regulation

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