The antigenotoxic potential of dietary flavonoids

Luca, Vlad Simon; Miron, Anca; Aprotosoaie, Ana Clara

doi:10.1007/s11101-016-9457-1

Cited by 34 publications

(28 citation statements)

References 134 publications

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“…Ethanol (absolute, AR, Merck) and dichloromethane (anhydrous, ≥ 99.8%, Sigma 12 Aldrich) were used as received without further purification. A flavonoid concentration of 10 13 µmol dm 3 was chosen for monolayer studies as it is in the range of physiological uptake 14 concentrations in body 20 and a dose dependent response was investigated in this range via RCV. 15…”

Section: Methodsmentioning

confidence: 99%

“…Their cleaning 20 procedure has been previously described in detail. 12 Electrodeposition of Hg on Pt electrode was 21 performed in a standard three electrode cell that contains Ag/AgCl, 3.5 mol dm 3 KCl as 22 reference electrode and platinum rod as a counter electrode. Electrodes were connected to an 23 deposition, the surface of Hg is cleaned in situ by flushing the system with PBS buffer at the 4 voltage of ~ 3.0 V and 100 200 µL of the lipid solution was injected into the system at the same 5 voltage, as described previously 15 .…”

Section: Electrochemical Measurements 16mentioning

confidence: 99%

“…At the concentrations of 10 µmol dm 3 (red line in Figure 2), the most significant changes in 12 DOPC properties following introduction of flavonoids were seen with quercetin and kaempferol 13 represented as a total capacitance peak current suppression and an increase in capacitance 14 baseline height. Tiliroside showed a smaller effect; naringenin, hesperetin and catechin displayed 15 an apparently even weaker interaction with DOPC -displayed as an intermediate capacitance 16…”

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confidence: 98%

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Experimental Modeling of Flavonoid–Biomembrane Interactions

Sanver

Murray²,

Sadeghpour³

et al. 2016

Langmuir

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and visualization of the surface with BAM revealed a pronounced monolayer stabilization effect 10 with both quercetin and tiliroside, whereas rutin disrupted the monolayer structure rendering the 11 surface entirely smooth. SAXS showed a monotonous membrane thinning for all compounds 12 studied associated with an increase in the root mean square fluctuations of the membrane. Rutin, 13 quercetin and tiliroside decreased the bilayer thickness of DOPC by ~0.45 Å, 0.8 Å, and 1.1 Å at 14 6 mol %, respectively. In addition to the novelty of using lipid monolayers to systematically 15 characterize the structure activity relationship (SAR) of a variety of flavonoids; this is the first 16 report investigating the effect of tiliroside with biomimetic membrane models. All the flavonoids 17 studied are believed to be localized in the lipid/water interface region. Both this localization and 18 the membrane perturbations have implications for their therapeutic activity.

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Section: Methodsmentioning

confidence: 99%

Section: Electrochemical Measurements 16mentioning

confidence: 99%

mentioning

confidence: 98%

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Experimental Modeling of Flavonoid–Biomembrane Interactions

Sanver

Murray²,

Sadeghpour³

et al. 2016

Langmuir

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“…It has been shown that flavonoids have effects against DNA damage induced by various genotoxic agents, that is, principally by the ability to protect against ROS produced and by the modulation of enzymes responsible for bioactivation and detoxification of genotoxic agents. A relationship has been reported between structure and activity from flavonoids in the protection of genetic material [34]. …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla

Soto-García

Rosales-Castro

Escalona-Cardoso

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Quercus sideroxyla is a wood species whose bark has phenolic compound and should be considered to be bioactive; the hypoglycemic and genotoxic properties of Q. sideroxyla bark were evaluated in this study. Total phenolic compound was determined in crude extract (CE) and organic extract (OE). The OE has the highest amount of phenols (724.1 ± 12.0 GAE/g). Besides, both CE and OE demonstrated effect over the inhibition of α-amylase in vitro. Hypoglycemic activity was assessed by glucose tolerance curve and the area under curve (UAC); OE showed the highest hypoglycemic activity. In addition, diabetes was induced by streptozotocin (65 mg/kg) and the extracts (50 mg/kg) were administered for 10 days; OE showed hypoglycemic effect compared with diabetic control and decreased hepatic lipid peroxidation. Acute toxicity and genotoxicity were evaluated in CE; results of acute toxicity did not show any mortality. Besides, the comet assay showed that CE at a dose of 100 mg/kg did not show any genotoxic effect when evaluated at 24 h, whereas it induced slight damage at 200 mg/kg, with the formation of type 1 comets.

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“…Further, Luca et al (2016) highlighted the antigenotoxic potential of dietary flavonoids. Some dietary flavonoids have shown an immense protective effect against DNA damage, induced by different genotoxic agents such as mycotoxins, food processing-derived contaminants, cytostatic agents, other medications (estrogenic and androgenic hormones), metal ions, radiopharmaceuticals and ionizing radiation, and etc.…”

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confidence: 99%

From plants to pharmacy shelf: natural products revival

Georgiev

2016

Phytochem Rev

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The antigenotoxic potential of dietary flavonoids

Cited by 34 publications

References 134 publications

Experimental Modeling of Flavonoid–Biomembrane Interactions

Experimental Modeling of Flavonoid–Biomembrane Interactions

Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla

From plants to pharmacy shelf: natural products revival

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