The antigenicity of silk-based biomaterials: sources, influential factors and applications

Long, Yanlin; Cheng, Xian; Tang, Qingming; Chen, Lili

doi:10.1039/d1tb00752a

Cited by 13 publications

(13 citation statements)

References 101 publications

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“…Silk comes from a wide range of sources, such as silkworm, spider silk, and peanut silk, which results in differences in the composition of silk protein. Treated silk proteins have low antigenicity and rarely cause immune reactions when implanted in vivo ( 77 ). The main factors causing an immune response are the immune cells and signaling molecules adsorbed on the material ( 78 ).…”

Section: Hydrogel Derived From Natural Polymersmentioning

confidence: 99%

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Zhang

Gonelle‐Gispert

et al. 2022

Front. Immunol.

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Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D). Currently, clinical islet transplantation is limited by allo - and autoimmunity that may cause partial or complete loss of islet function within a short period of time, and long-term immunosuppression is required to prevent rejection. Encapsulation into semipermeable biomaterials provides a strategy that allows nutrients, oxygen and secreted hormones to diffuse through the membrane while blocking immune cells and the like out of the capsule, allowing long-term graft survival and avoiding long-term use of immunosuppression. In recent years, a variety of engineering strategies have been developed to improve the composition and properties of encapsulation materials and to explore the clinical practicality of islet cell transplantation from different sources. In particular, the encapsulation of porcine islet and the co-encapsulation of islet cells with other by-standing cells or active ingredients for promoting long-term functionality, attracted significant research efforts. Hydrogels have been widely used for cell encapsulation as well as other therapeutic applications including tissue engineering, cell carriers or drug delivery. Here, we review the current status of various hydrogel biomaterials, natural and synthetic, with particular focus on islet transplantation applications. Natural hydrophilic polymers include polysaccharides (starch, cellulose, alginic acid, hyaluronic acid, chitosan) and peptides (collagen, poly-L-lysine, poly-L-glutamic acid). Synthetic hydrophilic polymers include alcohol, acrylic acid and their derivatives [poly (acrylic acid), poly (methacrylic acid), poly(acrylamide)]. By understanding the advantages and disadvantages of materials from different sources and types, appropriate materials and encapsuling methods can be designed and selected as needed to improve the efficacy and duration of islet. Islet capsule transplantation is emerging as a promising future treatment for T1D.

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Section: Hydrogel Derived From Natural Polymersmentioning

confidence: 99%

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Zhang

Gonelle‐Gispert

et al. 2022

Front. Immunol.

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“…The versatility of spidroins, along with their biocompatible and biodegradable nature ( Dams-Kozlowska et al, 2013 ; Müller-Herrmann and Scheibel, 2015 ; Deptuch et al, 2021 ), expand silk technologies to develop innovative bio-derived structural materials and place them as leading-edge biological macromolecules for various biomedical applications ( Altman et al, 2003 ; Long et al, 2021 ). Furthermore, through synthetic biology, it is possible to bioengineer rSSP with specific functional motifs, for the development of improved drug delivery systems, scaffold for tissue engineering and wound dressing ( Schacht and Scheibel, 2014 ; Nguyen et al, 2019 ; Salehi et al, 2020 ; Liu et al, 2021 ; Zhang et al, 2021 ).…”

Section: Bioengineering Of Spider Silks For Biomedical Applicationsmentioning

confidence: 99%

“…For this purpose, synthetic biology tools have been applied to explore the function and structure of different biological materials, such as proteins, polysaccharides, and polyesters ( Bryksin et al, 2014 ; Keating and Young, 2019 ). Because of their biocompatibility, biodegradation and non-immunogenicity, bio-derived materials have numerous applications in the medical field and are playing a central role in biomedical engineering ( Long et al, 2021 ; Lynch et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Bioengineering of spider silks for the production of biomedical materials

Bittencourt

Oliveira

Michalczechen-Lacerda

et al. 2022

Front. Bioeng. Biotechnol.

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Spider silks are well known for their extraordinary mechanical properties. This characteristic is a result of the interplay of composition, structure and self-assembly of spider silk proteins (spidroins). Advances in synthetic biology have enabled the design and production of spidroins with the aim of biomimicking the structure-property-function relationships of spider silks. Although in nature only fibers are formed from spidroins, in vitro, scientists can explore non-natural morphologies including nanofibrils, particles, capsules, hydrogels, films or foams. The versatility of spidroins, along with their biocompatible and biodegradable nature, also placed them as leading-edge biological macromolecules for improved drug delivery and various biomedical applications. Accordingly, in this review, we highlight the relationship between the molecular structure of spider silk and its mechanical properties and aims to provide a critical summary of recent progress in research employing recombinantly produced bioengineered spidroins for the production of innovative bio-derived structural materials.

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“…Unwanted immune system interactions may lead to off-target drug release during particle circulation, antibody formation, or induction of inflammation. As a heterogenic group of materials, silk differs in composition and structural characteristics that may affect its immunogenic properties [ 238 ]. Various sources of silk, processing methods, and material morphologies should be considered in terms of the body’s response to adjust the properties of the biomaterial to the desired or undesired immune response.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Various sources of silk, processing methods, and material morphologies should be considered in terms of the body’s response to adjust the properties of the biomaterial to the desired or undesired immune response. As a tunable material, silk may also have the potential for immune-related biomedical applications [ 238 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

Florczak

Deptuch

Kucharczyk

et al. 2021

Cancers

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For years, surgery, radiotherapy, and chemotherapy have been the gold standards to treat cancer, although continuing research has sought a more effective approach. While advances can be seen in the development of anticancer drugs, the tools that can improve their delivery remain a challenge. As anticancer drugs can affect the entire body, the control of their distribution is desirable to prevent systemic toxicity. The application of a suitable drug delivery platform may resolve this problem. Among other materials, silks offer many advantageous properties, including biodegradability, biocompatibility, and the possibility of obtaining a variety of morphological structures. These characteristics allow the exploration of silk for biomedical applications and as a platform for drug delivery. We have reviewed silk structures that can be used for local and systemic drug delivery for use in cancer therapy. After a short description of the most studied silks, we discuss the advantages of using silk for drug delivery. The tables summarize the descriptions of silk structures for the local and systemic transport of anticancer drugs. The most popular techniques for silk particle preparation are presented. Further prospects for using silk as a drug carrier are considered. The application of various silk biomaterials can improve cancer treatment by the controllable delivery of chemotherapeutics, immunotherapeutics, photosensitizers, hormones, nucleotherapeutics, targeted therapeutics (e.g., kinase inhibitors), and inorganic nanoparticles, among others.

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The antigenicity of silk-based biomaterials: sources, influential factors and applications

Abstract: Silk is an ancient material which acts important roles in numerous biomedical applications, such as tissue regeneration, drug delivery, because of its excellent tunable mechanical properties and diverse physical structures....

Cited by 13 publications

References 101 publications

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Bioengineering of spider silks for the production of biomedical materials

Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

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