The antigen-specific memory CD8+ T-cell response induced by BCG in cattle resides in the CD8+γ/δTCR−CD45RO+ T-cell population

Hogg, Alison; Worth, Andrew; Beverley, Peter C. L.; Howard, Christopher; Villarreal‐Ramos, Bernardo

doi:10.1016/j.vaccine.2008.10.053

Cited by 24 publications

(17 citation statements)

References 52 publications

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“…paratuberculosis-infected ileal compartments may be consistent with the coexpression of CD8 on bovine ␥␦TcR effector cells (58) and are consistent with previous reports that ␥␦TcR and CD8 ϩ T cell numbers increase in the laminae propriae of cows and goats with clinical Johne's disease (59,60). Although ␥␦TcR cells have been linked to protection against intracellular pathogens (61), an in vitro model of M. avium subsp.…”

Section: Discussionsupporting

confidence: 90%

Host Responses to Persistent Mycobacterium avium Subspecies paratuberculosis Infection in Surgically Isolated Bovine Ileal Segments

Charavaryamath

González-Cano

Fries

et al. 2013

Clin Vaccine Immunol

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A lack of appropriate disease models has limited our understanding of the pathogenesis of persistent enteric infections with Mycobacterium avium subsp. paratuberculosis. A model was developed for the controlled delivery of a defined dose of M. avium subsp. paratuberculosis to surgically isolated ileal segments in newborn calves. The stable intestinal segments enabled the characterization of host responses to persistent M. avium subsp. paratuberculosis infections after a 9-month period, including an analysis of local mucosal immune responses relative to an adjacent uninfected intestinal compartment. M. avium subsp. paratuberculosis remained localized at the initial site of intestinal infection and was not detected by PCR in the mesenteric lymph node. M. avium subsp. paratuberculosis-specific T cell proliferative responses included both CD4 and ␥␦ T cell receptor (␥␦TcR) T cell responses in the draining mesenteric lymph node. The levels of CD8 ؉ and ␥␦TcR ؉ T cells increased significantly (P < 0.05) in the lamina propria, and M. avium subsp. paratuberculosis-specific tumor necrosis factor alpha (TNF-␣) and gamma interferon secretion by lamina propria leukocytes was also significantly (P < 0.05) increased. There was a significant (P < 0.05) accumulation of macrophages and dendritic cells (DCs) in the lamina propria, but the expression of mucosal toll-like receptors 1 through 10 was not significantly changed by M. avium subsp. paratuberculosis infection. In conclusion, surgically isolated ileal segments provided a model system for the establishment of a persistent and localized enteric M. avium subsp. paratuberculosis infection in cattle and facilitated the analysis of M. avium subsp. paratuberculosis-specific changes in mucosal leukocyte phenotype and function. The accumulation of DC subpopulations in the lamina propria suggests that further investigation of mucosal DCs may provide insight into host responses to M. avium subsp. paratuberculosis infection and improve vaccine strategies to prevent M. avium subsp. paratuberculosis infection.

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Section: Discussionsupporting

confidence: 90%

Host Responses to Persistent Mycobacterium avium Subspecies paratuberculosis Infection in Surgically Isolated Bovine Ileal Segments

Charavaryamath

González-Cano

Fries

et al. 2013

Clin Vaccine Immunol

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“…These findings corroborate previous reports and help provide the missing link between NSAIDs, memory B-cells and a possible mechanism by which NSAIDs might exert affect vaccine response in the aged. Recently, it has been found that activated γ-δ T-cells can regulate the organization of B-cells within follicles of lymphoid tissues; they are also crucial in the induction of vaccine-mediated immunity in various animal models [45, 46]. Interestingly, we noted that at baseline, NSAIDs users had a significantly lower proportion of γ-δ T-cells.…”

Section: Discussionmentioning

confidence: 61%

Immune response to influenza vaccination in the elderly is altered by chronic medication use

et al. 2018

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BackgroundThe elderly patient population is the most susceptible to influenza virus infection and its associated complications. Polypharmacy is common in the aged, who often have multiple co-morbidities. Previous studies have demonstrated that commonly used prescription drugs can have extensive impact on immune defenses and responses to vaccination. In this study, we examined how the dynamics of immune responses to the two influenza A virus strains of the trivalent inactivated influenza vaccine (TIV) can be affected by patient’s history of using the prescription drugs Metformin, NSAIDs or Statins.ResultsWe provide evidence for differential antibody (Ab) production, B-cell phenotypic changes, alteration in immune cell proportions and transcriptome-wide perturbation in individuals with a history of long-term medication use, compared with non-users. We noted a diminished response to TIV in the elderly on Metformin, whereas those on NSAIDs or Statins had higher baseline responses but reduced relative increases in virus-neutralizing Abs (VNAs) or Abs detected by an enzyme-linked immunosorbent assay (ELISA) following vaccination.ConclusionCollectively, our findings suggest novel pathways that might underlie how long-term medication use impacts immune response to influenza vaccination in the elderly. They provide a strong rationale for targeting the medication-immunity interaction in the aged population to improve vaccination responses.Electronic supplementary materialThe online version of this article (10.1186/s12979-018-0124-9) contains supplementary material, which is available to authorized users.

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“…The expression of CD45RO is considered a reliable marker to monitor activated CD4 and CD8 T cells in bovine [43,44]. In the context of primary infection with BRSV, CD8 T cells are the predominant subset recruited to the airways [45] and prior vaccination with inactivated or live-attenuated virus can modify the pattern of T cell responses [46].…”

Section: Discussionmentioning

confidence: 99%

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus

Riffault¹,

Meyer

Deplanche

et al. 2010

Vaccine

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Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively. Efficacy of commercial bovine vaccines needs improvement and no human vaccine is licensed yet. We reported that nasal vaccination with the HRSV nucleoprotein produced as recombinant ring-shaped nanoparticles (N(SRS)) protects mice against a viral challenge with HRSV. The aim of this work was to evaluate this new vaccine that uses a conserved viral antigen, in calves, natural hosts for BRSV. Calves, free of colostral or natural anti-BRSV antibodies, were vaccinated with N(SRS) either intramuscularly, or both intramuscularly and intranasally using Montanide ISA71 and IMS4132 as adjuvants and challenged with BRSV. All vaccinated calves developed anti-N antibodies in blood and nasal secretions and N-specific cellular immunity in local lymph nodes. Clinical monitoring post-challenge demonstrated moderate respiratory pathology with local lung tissue consolidations for the non-vaccinated calves that were significantly reduced in the vaccinated calves. Vaccinated calves had lower viral loads than the non-vaccinated control calves. Thus N(SRS) vaccination in calves provided cross-protective immunity against BRSV infection without adverse inflammatory reaction.

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The antigen-specific memory CD8+ T-cell response induced by BCG in cattle resides in the CD8+γ/δTCR−CD45RO+ T-cell population

Cited by 24 publications

References 52 publications

Host Responses to Persistent Mycobacterium avium Subspecies paratuberculosis Infection in Surgically Isolated Bovine Ileal Segments

Host Responses to Persistent Mycobacterium avium Subspecies paratuberculosis Infection in Surgically Isolated Bovine Ileal Segments

Immune response to influenza vaccination in the elderly is altered by chronic medication use

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus

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