The Antifungal Activity of Bee Venom against Dermatophytes

Yu, Areum; Kim, Jum-Ji; Park, Gil-Sun; Oh, Sumi; Han, Chung Sub; Lee, Mi-Young

doi:10.3839/jabc.2011.052

Cited by 27 publications

(21 citation statements)

References 32 publications

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“…1 ). However, Yu et al [ 38 ] reported that the antifungal activities of BV against Trichophyton mentagrophytes and Trichophyton rubrum were much stronger than those of fluconazole, one of the commercial antifungal drugs that is currently being used. In the current study, amphotericin B was used as a positive control: amphotericin B is a fungicidal agent that is widely used to treat serious systemic infections [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal Activity of Bee Venom and Sweet Bee Venom against Clinically Isolated Candida albicans

Lee

2016

J. Pharmacopunct

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Objectives:The purpose of this study was to investigate the antifungal effect of bee venom (BV) and sweet bee venom (SBV) against Candida albicans (C. albicans) clinical isolates.Methods:In this study, BV and SBV were examined for antifungal activities against the Korean Collection for Type Cultures (KCTC) strain and 10 clinical isolates of C. albicans. The disk diffusion method was used to measure the antifungal activity and minimum inhibitory concentration (MIC) assays were performed by using a broth microdilution method. Also, a killing curve assay was conducted to investigate the kinetics of the anti- fungal action.Results:BV and SBV showed antifungal activity against 10 clinical isolates of C. albicans that were cultured from blood and the vagina by using disk diffusion method. The MIC values obtained for clinical isolates by using the broth microdilution method varied from 62.5 μg/ mL to 125 μg/mL for BV and from 15.63 μg/mL to 62.5 μg/mL for SBV. In the killing-curve assay, SBV behaved as amphotericin B, which was used as positive control, did. The antifungal efficacy of SBV was much higher than that of BV.Conclusion:BV and SBV showed antifungal activity against C. albicans clinical strains that were isolated from blood and the vagina. Especially, SBV might be a candidate for a new antifungal agent against C. albicans clinical isolates.

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Section: Discussionmentioning

confidence: 99%

Antifungal Activity of Bee Venom and Sweet Bee Venom against Clinically Isolated Candida albicans

Lee

2016

J. Pharmacopunct

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“…BV or its series of components have shown a broad array of effects from anti-inflammatory agents, anti-nociceptive, antibacterial, to anti-tumorous effects 1 2 3 4 5 6 7 8 . Extensive in vitro studies have confirmed the versatile properties that BV retains.…”

Section: Discussionmentioning

confidence: 99%

“…One theory is that while mellitin induces reactive oxygen species to generate the antifungal effect, other components such as phospholipase A2, hyaluronidase which respectively raise the permeation of the cell membrane and the capillary membranes are necessary to give the whole antifungal effect 1 13 14 22 23 . Additionally, studies state that the lipids and carbohydrates in the venom may act as an opsonin for further inflammatory responses to repeatedly generate the antifungal effect 22 23 .…”

Section: Discussionmentioning

confidence: 99%

“…The antifungal activities of BV and sweet BV against 10 clinical isolates of Candida albicans that were cultured from blood and the vagina showed antifungal activity determined by using the disk diffusion assay, the broth micro-dilution assay and the killing-curve assay 15 . Moreover, antifungal activity of BV against T. rubrum and T. mentagrophytes showed stronger effect than that of fluconazole 1 . However, the underlying mechanism and the principal component from BV that elicits the antifungal effect needs to be determined.…”

Section: Introductionmentioning

confidence: 91%

“…Bee venom (BV) extracted from Apis mellifera L. has been utilized for centuries as a suitable pain killer and an anti-inflammatory agent for various chronic diseases 1 2 3 4 5 . A number of recent studies further state the anti-mutagenic, anti-nociceptive, radio-protective, anti-tumorous and antibiotic properties of the BV 5 6 7 8 .…”

Section: Introductionmentioning

confidence: 99%

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Antifungal Effects of Bee Venom Components onTrichophyton rubrum: A Novel Approach of Bee Venom Study for Possible Emerging Antifungal Agent

Park

Kwon

et al. 2018

Ann Dermatol

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BackgroundBee venom (BV) has been widely investigated for potential medical uses. Recent inadvertent uses of BV based products have shown to mitigate signs of fungal infections. However, the component mediating the antifungal effect has not been identified.ObjectiveThis investigation compares bee venom in its whole and partial forms to evaluate the possible component responsible for the antifungal effect.MethodsForty-eight plates inoculated with Trichophyton rubrum were allocated into four groups. The groups were treated with raw BV (RBV), melittin, apamin and BV based mist (BBM) respectively and each group was further allocated accordingly to three different concentrations. The areas were measured every other day for 14 days to evaluate the kinetic changes of the colonies.ResultsThe interactions of ratio differences over interval were confirmed in groups treated with RBV and BBM. In RBV, the level of differences were achieved in groups treated with 10 mg/100 µl (p=0.026) and 40 mg/100 µl (p=0.000). The mean difference of ratio in groups treated with RBV was evident in day 3 and day 5. The groups that were treated with melittin or apamin did not show any significant interaction. In BBM groups, the significant levels of ratio differences over time intervals were achieved in groups treated with 200 µl/100 µl (p=0.000) and 300 µl/100 µl (p=0.030).ConclusionThe the bee venom in its whole form delivered a significant level of inhibition and we concluded that the venom in separated forms are not effective. Moreover, BV based products may exert as potential antifungal therapeutics.

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Antifungal and antibiofilm activities of bee venom loaded on chitosan nanoparticles: a novel approach for combating fungal human pathogens

El-Didamony

Kalaba

El‐Fakharany

et al. 2022

World J Microbiol Biotechnol

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The prevalence of opportunistic human fungal pathogens is increasing worldwide, and antimicrobial resistance is one of the greatest medical challenges the world faces. Therefore, this study aimed to develop a novel agent to control fungal pathogens. The honeybee products (honey, royal jelly, propolis, bee bread, and bee venom) were screened against unicellular fungal (UCF) pathogens (Cryptococcus neoformans, Kodamaea ohmeri, and Candida albicans) and the bee venom was only exhibited an inhibitory effect against them. The protein contents of crude bee venom were separated using the gel filtration technique into eight fractions which were visualized on sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE) to confirm the presence of five bands with molecular weights of 65, 43, 21, 15, and 3 KDa. Bee venom (BV) of Apis mellifera loaded chitosan nanoparticles were prepared by the ionotropic gelation method. The encapsulation efficiency%, average size, zeta potentials, and surface appearance by Transmission electron microscope (TEM) were evaluated for the prepared nanoparticles. The minimum inhibitory concentration (MIC) of crude BV and BV loaded chitosan nanoparticles (BV-CNPs) was evaluated against the offer mentioned UCF where the MIC values of crude BV were 6.25, 3.12 & 6.25 while MIC values in the case of BV-CNPs were decreased to 3.12, 3.12 & 1.56 mg/ml against C. neoformans, K. ohmeri and C. albicans, respectively. Also, the results showed that BV-CNPs suppressed the biofilm formation as well as yeast to hyphal transition formed by the examined UCF. These results revealed that BV-CNPs are a promising natural compound for fungal pathogens treatment. Graphical abstract

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The Antifungal Activity of Bee Venom against Dermatophytes

Cited by 27 publications

References 32 publications

Antifungal Activity of Bee Venom and Sweet Bee Venom against Clinically Isolated Candida albicans

Antifungal Activity of Bee Venom and Sweet Bee Venom against Clinically Isolated Candida albicans

Antifungal Effects of Bee Venom Components onTrichophyton rubrum: A Novel Approach of Bee Venom Study for Possible Emerging Antifungal Agent

Antifungal and antibiofilm activities of bee venom loaded on chitosan nanoparticles: a novel approach for combating fungal human pathogens

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