The Antidiabetic Activity of 3,5-Dimethylpyrazoles

Platinum(II) and palladium(II) complexes with (N,N′) and (C,N,N′)− ligands derived from pyrazole as anticancer and antimalarial agents: Synthesis, characterization and in vitro activities

“…The preparation of ligands 1a and 1b was carried out by a modification of former literature protocols [57,58] consisting in the alkylation of 1H-pyrazole and 3,5-dimethyl-1H-pyrazole respectively with 2-dimethylaminoethyl chloride using sodamide as a base (Scheme 1). The best yield for the synthesis of 1c was obtained by alkylation of 3,5-diphenyl-1H-pyrazole using Aliquat 336 as a phase transfer catalyst.…”

Synthesis and biological evaluation of fluoropyrazolesulfonylurea and thiourea derivatives as possible antidiabetic agents

“…Furthermore, 5-aminopyrazoles and 3-trifluoromethylpyrazoles with a wide array of groups at N-1 and C-4 were reported to be selective inhibitors of cyclooxygenase [8][9][10] and have antidiabetic 11 properties. However, since several 3,5-dimethylpyrazoles possess hypoglycemic activities as much as 100 times that of tolbutamide in glucose-primed intact rats [12][13][14] studies have been conducted in our group on the synthesis of 3,5-disubstituted pyrazoles [15][16][17][18][19][20] in order to have optimum molecular scaffold for the proposed biological activity.…”

Synthesis and biological evaluation of new 3-trifluoromethylpyrazolesulfonyl-urea and thiourea derivatives as antidiabetic and antimicrobial agents

“…Furthermore, 5-aminopyrazoles and 3-trifluoromethylpyrazoles with a wide array of groups at N-1 and C-4 were reported to be selective inhibitors of cyclooxygenase [10][11][12] and have antidiabetic [13], herbicidal [14] and antibacterial properties [15]. However, since several 3,5-dimethylpyrazoles possess hypoglycemic activities as much as 100 times that of tolbutamide in glucose-primed intact rats [16][17][18][19], studies have been conducted in our group on the synthesis of new 3,5-disubstituted pyrazoles [20][21][22][23][24][25]. In continuation of our previous work in the preparation of 3,5-disubstituted pyrazole [21][22][23][24][25][26][27][28][29] and fluorinated pyrazole [30,31] benzenesulfonylurea and thiourea derivatives as well as their cyclic sulfonylthioureas, many new trifluoromethyl pyrazole derivatives of these classes were synthesized and were tested for hypoglycemic and antimicrobial activities.…”