The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system

Effects of fisetin on oxaliplatin-induced neuropathic pain in mice

“…It was also observed that fisetin also prevented the development of depressive-like symptoms as evidenced by reduced immobility duration in the FST, a widely used mice model for the screening of antidepressants. Because fisetin possesses antidepressant-like activity in healthy animals (Zhen et al, 2012), this effect could be due to its antinociceptive action, its antinociceptive action or more likely the combination of both effects. This could be a highly useful feature as a novel analgesic given the high prevalence of comorbidity of chronic pain and depression (Li, 2014).…”

“…It has a wide variety of pharmacological activities such as antioxidant (Khan et al, 2013), anti-inflammatory (Tordera et al, 1994), anti-allergic (Cheong et al, 1998), cancer chemopreventive (Ravichandran et al, 2011), neuroprotective activities (Patel et al, 2012) and antidepressant-like activities (Zhen et al, 2012). Because antidepressants are frequently used to treat persistent and neuropathic pain, this study examined the potential antinociceptive actions of fisetin …”

In vitro and in vivo characterization of PA01, a novel promising triple reuptake inhibitor

“…On the fourth day, mice received oral administration of DVS (16 mg/kg), PA01 (8, 16, and 32 mg/kg) or vehicle 60 min prior to the TST testing. The procedure and dose of pCPA were based on previous studies [23].…”

Fisetin exerts antihyperalgesic effect in a mouse model of neuropathic pain: engagement of spinal serotonergic system

“…It has a wide variety of pharmacological activities such as anti-allergic8, cancer chemo-preventive9 and neuroprotective activities10. Recently, we originally revealed that fisetin possesses anti-depression property in experimental animals11. As antidepressant drugs are clinically used to treat persistent and neuropathic pain, we reasoned that fisetin may also have therapeutic potentials in fighting chronic neuropathic pain.…”

“…Furthermore, we explored the mechanisms underlying the actions of fisetin in the context of neuropathic pain. We hypothesized involvement of monoaminergic system, since it is not only substantially implicated in the descending pain regulation12, but is responsible for the antidepressant-like action of fisetin11. Finally, based on the well known co-morbidity between neuropathic pain and mood disorders, esp.…”