The antidepressant fluoxetine alters mechanisms of pre- and post-copulatory sexual selection in the eastern mosquitofish (Gambusia holbrooki)

Bertram, Michael G.; Ecker, Tiarne E.; Wong, Bob B. M.; O'Bryan, Moira K; Baumgartner, John B.; Martin, Jake M.; Saaristo, Minna

doi:10.1016/j.envpol.2018.03.006

Cited by 54 publications

(40 citation statements)

References 88 publications

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“…For all three treatments, fish were held in flow-through systems (24 h cycling), with eight tanks per treatment (24 tanks total; housing approximately 20 fish per tank) over the 28 days. Exposure was performed following previously established protocols (see electronic supplementary material, S1.1; [33][34][35][36]). During the exposure, gas chromatography coupled to tandem mass spectrometry was used for analytical verification of fluoxetine concentrations (described in [36]).…”

Section: Methodsmentioning

confidence: 99%

“…Exposure was performed following previously established protocols (see electronic supplementary material, S1.1; [33][34][35][36]). During the exposure, gas chromatography coupled to tandem mass spectrometry was used for analytical verification of fluoxetine concentrations (described in [36]). During both the laboratory acclimation and exposure period, fish were maintained in aged carbon-filtered freshwater (pH: 6.9-7.9) under a 24 h light : dark cycle (7.00-18.00 light), and fed ad libitum once daily with commercial fish food (Otohime Hirame larval diet).…”

Section: Methodsmentioning

confidence: 99%

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Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish

et al. 2019

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Psychoactive pollutants, such as antidepressants, are increasingly detected in the environment. Mounting evidence suggests that such pollutants can disrupt the behaviour of non-target species. Despite this, few studies have considered how the response of exposed organisms might be mediated by social context. To redress this, we investigated the impacts of two environmentally realistic concentrations of a pervasive antidepressant pollutant, fluoxetine, on foraging behaviour in fish ( Gambusia holbrooki ), tested individually or in a group. Fluoxetine did not alter behaviour of solitary fish. However, in a group setting, fluoxetine exposure disrupted the frequency of aggressive interactions and food consumption, with observed effects being contingent on both the mean weight of group members and the level of within-group variation in weight. Our results suggest that behavioural tests in social isolation may not accurately predict the environmental risk of chemical pollutants for group-living species and highlight the potential for social context to mediate the effects of psychoactive pollutants in exposed wildlife.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish

et al. 2019

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“…The adverse effects of SSRIs on physiology and neurodevelopment have been particularly well studied in fish. Numerous studies have demonstrated that fish exposed to a wide range of environmentally relevant concentrations of SSRIs or other antidepressants exhibit substantial physiological and neurological changes in a sex- and dose-dependent manner [ 31 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. The observed effects of antidepressants in fish include: changes in behavior (e.g., mating behavior, predator avoidance, anxiety, and aggression); substantial developmental and physiological abnormalities; changes in sexual selection, growth, and sperm count; and mortality.…”

Section: Introductionmentioning

confidence: 99%

Impacts of Psychopharmaceuticals on the Neurodevelopment of Aquatic Wildlife: A Call for Increased Knowledge Exchange across Disciplines to Highlight Implications for Human Health

Chan

Nutting

Natterson

et al. 2021

IJERPH

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The global use of psychopharmaceuticals such as antidepressants has been steadily increasing. However, the environmental consequences of increased use are rarely considered by medical professionals. Worldwide monitoring efforts have shown that pharmaceuticals are amongst the multitude of anthropogenic pollutants found in our waterways, where excretion via urine and feces is thought to be the primary mode of pharmaceutical contamination. Despite the lack of clarity surrounding the effects of the unintentional exposure to these chemicals, most notably in babies and in developing fetuses, the US Environmental Protection Agency does not currently regulate any psychopharmaceuticals in drinking water. As the underlying reasons for the increased incidence of mental illness—particularly in young children and adolescents—are poorly understood, the potential effects of unintentional exposure warrant more attention. Thus, although links between environmental contamination and physiological and behavioral changes in wildlife species—most notably in fish—have been used by ecologists and wildlife biologists to drive conservation policy and management practices, we hypothesize that this knowledge may be underutilized by medical professionals. In order to test this hypothesis, we created a hierarchically-organized citation network built around a highly-cited “parent” article to explore connections between aquatic toxicology and medical fields related to neurodevelopment. As suspected, we observed that studies in medical fields such as developmental neuroscience, obstetrics and gynecology, pediatrics, and psychiatry cite very few to no papers in the aquatic sciences. Our results underscore the need for increased transdisciplinary communication and information exchange between the aquatic sciences and medical fields.

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“…<1 month) that represent a small fraction of the model species' lifespan. [25][26][27][28][29][30] This is problematic because effects that persist after long-term exposure may have important consequences on the lifetime fitness of individuals and population dynamics, making studies addressing effects of chronic exposure to pharmaceutical contaminants, such as fluoxetine, an urgent research priority.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Pharmaceutical Contamination and Temperature Stress Disrupt Fish Behavior

Wiles

Martin

Tan

et al. 2020

Environ. Sci. Technol.

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Natural environments are subject to a range of anthropogenic stressors, with pharmaceutical pollution being among the fastest-growing agents of global change.However, despite wild animals living in complex multi-stressor environments, interactions between pharmaceutical exposure and other stressors remain poorly understood. Accordingly, we investigated effects of long-term exposure to the pervasive pharmaceutical contaminant fluoxetine (Prozac ® ), and acute temperature stress, on reproductive behaviours and activity levels in the guppy (Poecilia reticulata). Fish were exposed to environmentally realistic fluoxetine concentrations (measured average: 38 or 312 ng/L) or a solvent control for 15 months using a mesocosm system. Additionally, fish were subjected to one of three acute (24 h) temperature treatments: cold stress ( 18°C), heat stress (32 °C) or a control (24 °C). We found no evidence for interactive effects of fluoxetine exposure and temperature stress on guppy behaviour. However, both stressors had independent impacts. Fluoxetine exposure resulted in increased male coercive copulatory behaviour, while fish activity levels were unaffected. Under cold-temperature stress, both sexes were less active and males exhibited less frequent reproductive behaviours. Our results demonstrate that long-term exposure to a common pharmaceutical pollutant, and acute temperature stress, alter fundamental fitnessrelated behaviours in fish, potentially shifting population dynamics in contaminated ecosystems.

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The antidepressant fluoxetine alters mechanisms of pre- and post-copulatory sexual selection in the eastern mosquitofish (Gambusia holbrooki)

Cited by 54 publications

References 88 publications

Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish

Field-realistic antidepressant exposure disrupts group foraging dynamics in mosquitofish

Impacts of Psychopharmaceuticals on the Neurodevelopment of Aquatic Wildlife: A Call for Increased Knowledge Exchange across Disciplines to Highlight Implications for Human Health

Long-Term Pharmaceutical Contamination and Temperature Stress Disrupt Fish Behavior

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