The anticonvulsant hypersensitivity syndrome

Baba, Motoki; Karakaş, Mehmet; Aksungur, Varol Lütfü; Homan, Seydo; Yücel, Aydın; Acar, M. Alpaslan; Memişoğlu, Hamdi R.

doi:10.1046/j.1468-3083.2003.00750.x

Cited by 31 publications

(29 citation statements)

References 10 publications

(17 reference statements)

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“…Alopecia is not dose related and can be prevented by treatment with zinc and selenium-containing vitamin. VPA was also implicated in Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell Syndrom) [142]. …”

Section: Side Effects Of Vpamentioning

confidence: 99%

Molecular and Therapeutic Potential and Toxicity of Valproic Acid

Chateauvieux

Morceau

Dicato

et al. 2010

Journal of Biomedicine and Biotechnology

397

308

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Valproic acid (VPA), a branched short-chain fatty acid, is widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of Gamma Amino Butyrate (GABA) transaminobutyrate and of ion channels. VPA was recently classified among the Histone Deacetylase Inhibitors, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. VPA is a widely used drug, particularly for children suffering from epilepsy. Due to the increasing number of clinical trials involving VPA, and interesting results obtained, this molecule will be implicated in an increasing number of therapies. However side effects of VPA are substantially described in the literature whereas they are poorly discussed in articles focusing on its therapeutic use. This paper aims to give an overview of the different clinical-trials involving VPA and its side effects encountered during treatment as well as its molecular properties.

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Section: Side Effects Of Vpamentioning

confidence: 99%

Molecular and Therapeutic Potential and Toxicity of Valproic Acid

Chateauvieux

Morceau

Dicato

et al. 2010

Journal of Biomedicine and Biotechnology

397

308

View full text Add to dashboard Cite

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“…Generalized lymphadenopathy, hematologic disorders, high liver function tests, lactic dehydrogenase levels, gastrointestinal bleeding, acute tubular necrosis, pneumonia, bacterial conjunctivitis are considered as the indicators of internal organ involvement. 8 Cholestatic hepatitis accompanying TEN is rare in the literature. 9 In our case, the presence of high fever, maculopapular rash in the beginning and consequently the rise in hepatic enzymes can be assumed as infectious causes.…”

Section: Discussionmentioning

confidence: 99%

Dress Syndrome Due to Ciprofloxacin Use: Case Report

Serdar¹,

Akyüz²,

Gönenç³

et al. 2016

Turkiye Klinikleri J Dermatol

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“…Gabapentin could be considered as the most suitable anticonvulsant agent because it is not metabolized by this detoxification pathway. 8 Another alternative, levetiracetam, is increasingly being used as a phenytoin replacement to avoid the risk of these skin syndromes. 9 To optimize the prevention of these dangerous reactions, it is necessary to stress case occurrences to let clinicians know about the risk of these syndromes.…”

Section: Discussionmentioning

confidence: 99%

EMPACT Syndrome Associated with Phenobarbital

Fabbrocini¹,

Panariello²,

Pensabene³

et al. 2013

Dermatitis

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Intracranial malignancies can be complicated by seizure activity, and anticonvulsants such as phenytoin are usually administered to prevent this neurological kind of complication. Cranial radiation therapy is instead the treatment of choice when the tumor is unresectable. Anyway, the combination of phenytoin and cranial radiation therapy can lead to a rare and severe mucocutaneous complication called EMPACT syndrome. It is composed of "erythema (E) multiforme (M) associated with phenytoin (P) and (A) cranial radiation (C) therapy (T)." Herein, we report 2 cases of EMPACT syndrome related to the use of phenobarbital instead of phenytoin as usually described in literature.

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The anticonvulsant hypersensitivity syndrome

Abstract: It is essential that due importance be given to the development of an eruption in individuals to whom anticonvulsants are administered after craniotomy because anticonvulsant hypersensitivity syndrome is likely to be life-threatening.

Cited by 31 publications

References 10 publications

Molecular and Therapeutic Potential and Toxicity of Valproic Acid

Molecular and Therapeutic Potential and Toxicity of Valproic Acid

Dress Syndrome Due to Ciprofloxacin Use: Case Report

EMPACT Syndrome Associated with Phenobarbital

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