2003
DOI: 10.1046/j.1468-3083.2003.00750.x
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The anticonvulsant hypersensitivity syndrome

Abstract: It is essential that due importance be given to the development of an eruption in individuals to whom anticonvulsants are administered after craniotomy because anticonvulsant hypersensitivity syndrome is likely to be life-threatening.

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Cited by 31 publications
(29 citation statements)
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References 10 publications
(17 reference statements)
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“…Alopecia is not dose related and can be prevented by treatment with zinc and selenium-containing vitamin. VPA was also implicated in Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell Syndrom) [142]. …”
Section: Side Effects Of Vpamentioning
confidence: 99%
“…Alopecia is not dose related and can be prevented by treatment with zinc and selenium-containing vitamin. VPA was also implicated in Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell Syndrom) [142]. …”
Section: Side Effects Of Vpamentioning
confidence: 99%
“…Generalized lymphadenopathy, hematologic disorders, high liver function tests, lactic dehydrogenase levels, gastrointestinal bleeding, acute tubular necrosis, pneumonia, bacterial conjunctivitis are considered as the indicators of internal organ involvement. 8 Cholestatic hepatitis accompanying TEN is rare in the literature. 9 In our case, the presence of high fever, maculopapular rash in the beginning and consequently the rise in hepatic enzymes can be assumed as infectious causes.…”
Section: Discussionmentioning
confidence: 99%
“…Gabapentin could be considered as the most suitable anticonvulsant agent because it is not metabolized by this detoxification pathway. 8 Another alternative, levetiracetam, is increasingly being used as a phenytoin replacement to avoid the risk of these skin syndromes. 9 To optimize the prevention of these dangerous reactions, it is necessary to stress case occurrences to let clinicians know about the risk of these syndromes.…”
Section: Discussionmentioning
confidence: 99%