The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

Farha, Arakkaveettil Kabeer; Gan, Ren‐You; Li, Hua-Bin; Wu, Ding‐Tao; Atanasov, Atanas G.; Gul, Khalid; Zhang, Jiarong; Yang, Qiong‐Qiong; Corke, Harold

doi:10.1080/10408398.2020.1829541

Cited by 105 publications

(60 citation statements)

References 244 publications

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“…Rutin is a bioflavonoid glycoside with widespread pharmacological activities and has been applied for the treatment of diverse type of cancers, such as breast cancer, colon cancer, colorectal cancer, and leukemia [37]. Maeda et al.…”

Section: Resultsmentioning

confidence: 99%

Development and evaluation of poly adenosine 5′‐diphosphate‐ribose polymerase 1 immobilization‐based receptor chromatography

Dou

Zhu

et al. 2020

J of Separation Science

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Yanghe decoction is a traditional Chinese medicine prescription and has been used for breast cancer treatment for many years. However, the effective ingredients in the decoction have not been identified. The expression of poly(ADP‐ribose) polymerase‐1 is highly related to breast cancer. Using poly(ADP‐ribose) polymerase‐1 as a probe, we expressed the haloalkane dehalogenase‐tagged protein in BL21(DE3) E. coli, immobilized it on hexachlorocaproic acid‐modified macroporous silica gel, and established a poly(ADP‐ribose) polymerase‐1 chromatographic model. The feasibility of the model was verified by testing the retention behaviors of five drugs on the protein column. We applied the model in screening the bioactive components in yanghe decoction. Rutin, liquiritin, and a compound ([M‐H]– 681.7) were identified to be the potential bioactive ingredients. We studied the binding property between rutin and poly(ADP‐ribose) polymerase‐1 by injection amount dependent method, competitive studies, and molecular docking. We found that rutin can bind to the protein through the typical inhibitor binding site of the protein. Therefore, the chromatographic model is a useful tool to screen bioactive compounds from traditional Chinese medicine. The method is fast, reliable, and applicable to other functional proteins that can screen the potential lead compounds for the treatment of the related diseases.

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Section: Resultsmentioning

confidence: 99%

Development and evaluation of poly adenosine 5′‐diphosphate‐ribose polymerase 1 immobilization‐based receptor chromatography

Dou

Zhu

et al. 2020

J of Separation Science

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“…Hyperoside is a flavonoid-type flavone glycoside that has been reported to possess a wide range of pharmacological properties, such as an antioxidant agent (Park et al, 2016), anti-Alzheimer, anti-inflammatory and anticancer (Li et al, 2014).This is the same as astragalin, which presented several positive effects as antioxidant and anti-cancer (Riaz et al, 2018). Finally, rutin, which is a flavonoid, has antiinflammatory (Mostafa, 2018), anti-carcinogenic, and antioxidant activities (Farha et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Investigation of Phytochemical and Evaluation of Antioxidant and Antibacterial Activities from Abies Extract

Benouchenne¹,

Bellil²,

Akkal³

et al. 2021

BAS-SJKFU

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Algerian fir (Abies numidica de Lannoy) is an endemic evergreen tree belonging to the Pinaceae family. Little is known about this plant, and few papers have been reported, despite its traditional uses. The objectives of this study were to investigate the chemical composition of n-butanol extract from A. numidica leaves as well as to evaluate its biological activities (antibacterial and antioxidant). The total phenolics and total flavonoids were found in high amounts (381.15±22.70µg GAE/ml; 49.79±2.81 µg QE /ml, respectively). The data of the antibacterial effect showed a potential inhibitory zone, especially against Proteus vulgaris (17.5±0.70 mm). The antioxidant activity findings disclosed that this fraction has a moderate radical scavenging power and metal chelating ability, compared with the standards used. The liquid chromatography–mass spectrometry (LC–MS/MS) analysis results showed that the major compounds presented in this extract were hyperoside (399.91µg/g), astragalin (147.22 µg/g) and rutin (102.62 µg/g). Thus, A. numidica leaves were suggested as being useful to prevent free radicals and bacterial infections diseases.

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“…In addition, the transport of poorly aqueous soluble compounds by a molecular-carrier allows improvement of its bioavailability and therefore, its biological activities [177]. The polyphenols mentioned in this review have been subjected to various forms of nanoformulation, especially resveratrol [178], curcumin [179], quercetin [180], catechins [181], and to a lesser degree, rutin [32] and apigenin [182]. It appears from the literature that in vitro and in vivo bioactivities of nanoformulated polyphenols are generally much better than those obtained with free polyphenols, particularly in the cancer field.…”

Section: Nanoformulation Improvementmentioning

confidence: 99%

Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer

et al. 2021

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The Mediterranean diet is a central element of a healthy lifestyle, where polyphenols play a key role due to their anti-oxidant properties, and for some of them, as nutripharmacological compounds capable of preventing a number of diseases, including cancer. Due to the high prevalence of intestinal cancer (ranking second in causing morbidity and mortality), this review is focused on the beneficial effects of selected dietary phytophenols, largely present in Mediterranean cooking: apigenin, curcumin, epigallocatechin gallate, quercetin-rutine, and resveratrol. The role of the Mediterranean diet in the prevention of colorectal cancer and future perspectives are discussed in terms of food polyphenol content, the effectiveness, the plasma level, and the importance of other factors, such as the polyphenol metabolites and the influence of the microbiome. Perspectives are discussed in terms of microbiome-dependency of the brain-second brain axis. The emergence of polyphenol formulations may strengthen the efficiency of the Mediterranean diet in the prevention of cancer.

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The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

Cited by 105 publications

References 244 publications

Development and evaluation of poly adenosine 5′‐diphosphate‐ribose polymerase 1 immobilization‐based receptor chromatography

Development and evaluation of poly adenosine 5′‐diphosphate‐ribose polymerase 1 immobilization‐based receptor chromatography

Investigation of Phytochemical and Evaluation of Antioxidant and Antibacterial Activities from Abies Extract

Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer

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