The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)

Farghadani, Reyhaneh; Naidu, Rakesh

doi:10.1016/j.biopha.2023.115170

Cited by 24 publications

(7 citation statements)

References 155 publications

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“…Moreover, QC inhibits the expression of Hsp27, Hsp70, and Hsp90, which are implicated in cell survival in MDA-MB-231 cells. This inhibition leads to apoptosis, characterized by increased caspase activity and PARP cleavage [ 26 , 27 ]. Previous research has demonstrated the involvement of quercetin (QC) in modulating these proteins, leading to cell cycle arrest and apoptosis induction [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Combination of Etoposide and quercetin-loaded solid lipid nanoparticles Potentiates apoptotic effects on MDA-MB-231 breast cancer cells

Afarin,

Ahmadpour,

Hatami

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Combination of Etoposide and quercetin-loaded solid lipid nanoparticles Potentiates apoptotic effects on MDA-MB-231 breast cancer cells

Afarin,

Ahmadpour,

Hatami

et al. 2024

Heliyon

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“…Epidemiological evidence also indicates reduced incidence of coronary heart disease and related mortality due to the consumption of these fruits 5 . Other epidemiological studies show protective effects of citrus alkaloids against ischemic stroke 6 , 7 and cancer 8 . This latter observation is also supported by experimental data 9 .…”

Section: Introductionmentioning

confidence: 91%

Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations

Mohammed,

Mohácsi,

Naveed

et al. 2024

Sci Rep

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Recent experimental data shows that hesperetin, a citrus flavonoid, affects potassium channels and can prolong the QTc interval in humans. Therefore, in the present study we investigated the effects of hesperetin on various transmembrane ionic currents and on ventricular action potentials. Transmembrane current measurements and action potential recordings were performed by patch-clamp and the conventional microelectrode techniques in dog and rabbit ventricular preparations. At 10 µM concentration hesperetin did not, however, at 30 µM significantly decreased the amplitude of the IK1, Ito, IKr potassium currents. Hesperetin at 3–30 µM significantly and in a concentration-dependent manner reduced the amplitude of the IKs current. The drug significantly decreased the amplitudes of the INaL and ICaL currents at 30 µM. Hesperetin (10 and 30 µM) did not change the action potential duration in normal preparations, however, in preparations where the repolarization reserve had been previously attenuated by 100 nM dofetilide and 1 µg/ml veratrine, caused a moderate but significant prolongation of repolarization. These results suggest that hesperetin at close to relevant concentrations inhibits the IKs outward potassium current and thereby reduces repolarization reserve. This effect in certain specific situations may prolong the QT interval and consequently may enhance proarrhythmic risk.

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“…Different natural compounds obtained from plants have shown anticancer activity. Among these, polyphenols are a class of natural plant chemicals that have demonstrated anticancer properties [ 23 ]. These bioactives derive from phenylalanine and contain an aromatic ring with one or more hydroxyl groups.…”

Section: Curcumin and Its Anticancer Effectsmentioning

confidence: 99%

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Dourado,

Miranda,

de Oliveira

et al. 2024

Pharmaceutics

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Curcumin is a natural compound that has been widely investigated thanks to its various biological properties, including antiproliferative. This molecule acts on different cancers such as lung, breast, pancreatic, colorectal, etc. However, the bioactive actions of curcumin have limitations when its physicochemical properties compromise its pharmacological potential. As a therapeutic strategy against cancer, curcumin has been associated with inorganic nanoparticles. These nanocarriers are capable of delivering curcumin and offering physicochemical properties that synergistically enhance anticancer properties. This review highlights the different types of curcumin-based inorganic nanoparticles and discusses their physicochemical properties and in vivo anticancer activity in different models of cancer.

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The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)

Cited by 24 publications

References 155 publications

Combination of Etoposide and quercetin-loaded solid lipid nanoparticles Potentiates apoptotic effects on MDA-MB-231 breast cancer cells

Combination of Etoposide and quercetin-loaded solid lipid nanoparticles Potentiates apoptotic effects on MDA-MB-231 breast cancer cells

Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

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