The Anticancer, Anti-metastatic, Anti-oxidant, and Anti-angiogenic Activity of Chitosan-coated Parthenolide/Bovine Serum Albumin Nanoparticles

Albosultan, Ahmed Ibrahim; Ghobeh, Maryam; Tabrizi, Masoud Homayouni

doi:10.1007/s10904-023-02541-y

Cited by 3 publications

(1 citation statement)

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“…These results support the low toxicity and biocompatibility of designed carrier [43]. Considering the non-toxicity and biocompatibility of silica, gelatin and BSA, these ndings seem to be logical [44,45]. However, a toxic response was obtained by exposure the SiGe/BSA-FA@5FU carrier to both cancer and normal cells, which is due to the presence of 5FU.…”

Section: Toxicity Studiessupporting

confidence: 67%

Folate-targeted albumin modified silica-gelatin hybrid nanocarrier. Synthesis and release characterization

Niazi,

Ashjari

2024

Preprint

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A novel hybrid of BSA-folate modified silica-gelatin nanocarrier with surface area of about 422 m2/g was designed in the current study and loaded by fluorouracil with 70 % entrapment efficiency. The nanocarrier was evaluated in terms of pH-sensitive release behavior in simulated acidic condition of cancer tissue (pH=5.), and the normal physiological condition of the body (pH=7.4) for 96 h. In vitro drug release from nanocarriers indicated a partial burst release in the early times (34 and 21 % after 12 h in acidic and neutral media), which was followed by a sustained and gradual release profile until 96 h. In addition, an enhanced drug release was observed at acidic pH (65 % after 96 h) compared to natural medium (42 % after 96 h), confirming the pH-responsive behavior of the developed nanocarrier. The MTT assay showed low toxicity of drug-free carrier against normal HDF fibroblast, and the OVCAR-3 ovarian cancer cells. These outcomes support the proper function of designed hybrid nanocarrier in targeted drug delivery.

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Section: Toxicity Studiessupporting

confidence: 67%