1994
DOI: 10.1093/infdis/169.2.441
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The Antibody Response of Vitamin A-Deficient Rats to Pneumococcal Polysaccharide Is Enhanced through Coimmunization with Lipopolysaccharide

Abstract: Although the antibody response of vitamin A-deficient rats immunized with pneumococcal polysaccharide (SSS-III) was barely detectable, coimmunization with SSS-III plus 2 or 20 micrograms of Pseudomonas aeruginosa lipopolysaccharide (LPS) resulted in an anti-SSS-III response that was equal to or greater than that of vitamin A-sufficient rats immunized only with SSS-III. Doses of 2 and 20 micrograms of LPS, but not 0.1 and 0.5 micrograms, produced significant adjuvanticity, and LPS functioned as an adjuvant when… Show more

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Cited by 19 publications
(13 citation statements)
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“…Our reasoning in immunizing with PPS3 in conjunction with LPS was that the combination may upregulate cytokine production (IL-6 and TNF-␣), thus activating macrophages and promoting opsonization and complementmediated clearance in the lung microenvironment. Moreover, significantly higher serum anti-PPS3 IgM has been reported in rats coimmunized with PPS3 and LPS (9). Although LPS immunization did not decrease lung bacterial burden, we did observe a 26.8% decrease in bacteremia and an upregulation in pulmonary CCL2 at the mRNA level at 48 h p.i.…”
Section: Discussioncontrasting
confidence: 46%
See 1 more Smart Citation
“…Our reasoning in immunizing with PPS3 in conjunction with LPS was that the combination may upregulate cytokine production (IL-6 and TNF-␣), thus activating macrophages and promoting opsonization and complementmediated clearance in the lung microenvironment. Moreover, significantly higher serum anti-PPS3 IgM has been reported in rats coimmunized with PPS3 and LPS (9). Although LPS immunization did not decrease lung bacterial burden, we did observe a 26.8% decrease in bacteremia and an upregulation in pulmonary CCL2 at the mRNA level at 48 h p.i.…”
Section: Discussioncontrasting
confidence: 46%
“…Prior investigations that have examined the virulence of ST 3 in murine models concluded that a more vigorous, early immune response characterized by upregulation of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-␣) and interleukin-1␤ (IL-1␤) in the alveoli would promote macrophage function, opsonization, and phagocytic bacterial clearance (7,8). Previously, coimmunization with PPS3 and lipopolysaccharide (LPS) in rats markedly stimulated the anti-PPS3 response, suggesting that the adjuvant-like properties of LPS might be beneficial in promoting a stronger protective response to pneumococcal pneumonia infection (9).…”
mentioning
confidence: 99%
“…Some animal studies have suggested a role of vitamin A in the antibody response to T-cell-independent antigens such as pneumococcal polysaccharide (100), but a causal link cannot be established with certainty since interventions other than vitamin A repletion may trigger normal antibody responses in animals (99). It would be relevant to examine whether vitamin A supplementation in humans could enhance the response to this and other T-cell-independent antigens from encapsulated bacteria, including meningococcus and Haemophilus.…”
Section: T-cell-independent Humoral Responsesmentioning
confidence: 99%
“…The specific mechanisms underlying this increased risk of death have not been clearly defined but presumably involve impairment of specific and nonspecific host defense mechanisms (3). Although data from humans are limited, rodent studies indicate that vitamin A deficiency alters the Ab response to T cell-dependent Ags (4,5). Vitamin A deficiency decreases the IgA, IgG1, and IgE responses but increases the IgG2a response to viral infection (6 -8).…”
mentioning
confidence: 99%