The antibody response in experimental ocular toxoplasmosis

Garweg, Justus G.; Boehnke, Matthias

doi:10.1007/s00417-006-0274-x

Cited by 18 publications

(5 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with acquired disease, in contrast, manifest more uniformly a marked inflammatory response and usually harbour high levels of specific antibodies 31. In a rabbit model of acquired ocular toxoplasmosis, we have shown that high levels of local antibodies may persist over several months 32. Based on these observations, one might argue that patients with a stronger immune response and persisting high local antibody concentrations, that is otherwise healthy young patients with acquired disease, may achieve a better protection against reactivation, but this has as yet to be shown.…”

Section: Discussionmentioning

confidence: 92%

Recurrence characteristics in European patients with ocular toxoplasmosis

Garweg

Scherrer

Halberstadt

2008

British Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 92%

Recurrence characteristics in European patients with ocular toxoplasmosis

Garweg

Scherrer

Halberstadt

2008

British Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…In a significant proportion of patients (21%), a clinically relevant time lapse has to be expected between the onset of clinical symptoms and the activation of local antibody production, and this circumstance has been confirmed in a lapine model of ocular toxoplasmosis [53). In infection-naïve animals, the time lapse between inoculation with tachyzoites of Toxoplasma gondii and the local activation of specific antibody production may be up to 2 weeks.…”

Section: Time Lapse Between the Onset Of Symptoms And The Induction Omentioning

confidence: 99%

Diagnostic Approach to Ocular Toxoplasmosis

Garweg

Groot-Mijnes

Montoya

2011

Ocular Immunology and Inflammation

Self Cite

View full text Add to dashboard Cite

Toxoplasmic retinochoroiditis is deemed a local event, which may fail to evoke a detectable systemic immune response. A correct diagnosis of the disease is a necessary basis for estimating its clinical burden. This is not so difficult in a typical clinical picture. In atypical cases, further diagnostic efforts are to be installed. Although the aqueous humor may be analyzed for specific antibodies or the presence of parasitic DNA, the DNA burden therein is low, and in rare instances a confirmation would necessitate vitreous sampling. A laboratory confirmation of the diagnosis is frustrated by individual differences in the time elapsing between clinical symptoms and activation of specific antibody production, which may result in false negatives. In congenital ocular toxoplasmosis, a delay in the onset of specific local antibody production could reflect immune tolerance. Herein, the authors attempt to provide a simple and practicable algorithm for a clinically tailored diagnostic approach in atypical instances.

show abstract

“…The time lapse between the onset of the symptom and the induction of a local immune response is not clearly established and is always disputed. In a rabbit model of OT, the local activation of specific antibody production was found 2 weeks after inoculation of tachyzoite in naive animals and about 3 weeks in a rabbit model of reactivation 42. However, intraocular production of antibodies has been detected frequently in the first two weeks after the onset of symptoms in many patients.…”

Section: Discussionmentioning

confidence: 98%