The Antibody (Hemagglutinin) Response of Patients with Infections of the Urinary Tract

Needell, Mervin H.; Neter, Erwin; Staubitz, William J.; Bingham, Winifred A.

doi:10.1016/s0022-5347(17)67336-1

Cited by 39 publications

(12 citation statements)

References 12 publications

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“…We have not yet studied acute cystitis so we do not know whether the mucosal-submucosal response is similar to that seen in chronic cystitis. Also, we have not yet attempted demonstration of antibody in the human bladder wall, although local (31) and systemic (3)(4)(5)(6)(7) antibodies to urinary pathogens have been demonstrated in animals and in man, respectively. We hope that additional biopsy and postmortem studies will indicate whether the lymphocytes of the human bladder submucosa are capable of producing antibody.s We are currently studying the systemic antibody response in patients with E.coli infection.…”

Section: Discussionmentioning

confidence: 99%

Immunofluorescence Studies of the Bladder Defense Mechanism. I. Localization of Escherichia Coli in the Human Bladder

Drach

Cox

1967

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

Immunofluorescence Studies of the Bladder Defense Mechanism. I. Localization of Escherichia Coli in the Human Bladder

Drach

Cox

1967

J American Geriatrics Society

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“…From these data he concluded that localized disease failed to evoke immune responses. Needell, Neter, Staubitz, and Bingham studied 20 patients with infection of the urinary tract for the presence or development of circulating antibodies utilizing the more sensitive bacterial hemagglutination technique (17). In contrast to the observations of Hughes, significant titers of specific antibodies were present against 20 of the 40 antigens (organisms) isolated from these patients.…”

Section: (From the Department Of Internal Medicine The University Ofmentioning

confidence: 99%

The Role of Immunity in the Pathogenesis of Experimental Hematogenous Pyelonephritis

Sanford

Hunter

Souda

1962

The Journal of Experimental Medicine

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Hematogenous pyelonephritis was produced in rats utilizing multiple strains of Escherichia coli, a strain of Klebsiella pneumoniae, and a strain of Proteus mirabilis. Three patterns of hematogenous pyelonephritis occurred which represent an interrelationship between an immune response to the infecting bacteria and the development of obstructive uropathy as a consequence of infection. First, the course of pyelonephritis due to strains of Escherichia coli was acute, self-limited, and associated with the development of circulating agglutinins. Following healing, this pattern of infection was associated with acquired resistance to reinfection with the same bacterial strain. Second, the course of pyelonephritis due to a strain of Klebsiella pneumoniae type C was chronic. This infection was not associated with the production of circulating agglutinins against encapsulated strains. Acquired resistance to reinfection by the homotypic strain could not be demonstrated following eradication of infection but was produced by the passive transfer of concentrated antiserum. Third, pyelonephritis due to Proteus mirabilis was associated with circulating agglutinins and resistance to reinfection with the same organism following eradication of infection, yet the course was chronic. The chronicity appeared to be the consequence of obstructive uropathy resulting from calculi which developed during the course of the infection. Resistance to reinfection was demonstrated in infections with strains of E. coli and P. mirabilis. The resistance is associated with specific immunity as demonstrated by the observation that: (a) it is type-specific, (b) it is of at least 3 months' duration, and (c) it can be passively transferred by means of rabbit antiserum. Since K. pneumoniae failed to evoke capsular antibodies in the rat, resistance to infection with K. pneumoniae was produced only by means of passively transferred concentrated rabbit antiserum and not by prior infection. Immunity can be demonstrated to have a significant role in the pathogenesis of experimental hematogenous pyelonephritis only in the absence of obstructive uropathy.

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“…The hemagglutination procedure measures preferentially, though not exclusively, IgM antibodies [11]. Since the initial report in 1955 [19], this method has been widely employed, both in this country and abroad [1,2,6,9,10,12,15,18,32,37,38,40,41]. Also, as reported by HOLMGREN and HANSON [17], this test may detect related K antigens.…”

Section: Discussionmentioning

confidence: 96%

Patterns of Antibody Response of Children with Infections of the Urinary Tract

et al. 1970

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The Antibody (Hemagglutinin) Response of Patients with Infections of the Urinary Tract

Cited by 39 publications

References 12 publications

Immunofluorescence Studies of the Bladder Defense Mechanism. I. Localization of Escherichia Coli in the Human Bladder

Immunofluorescence Studies of the Bladder Defense Mechanism. I. Localization of Escherichia Coli in the Human Bladder

The Role of Immunity in the Pathogenesis of Experimental Hematogenous Pyelonephritis

Patterns of Antibody Response of Children with Infections of the Urinary Tract

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