The Antibiotic Susceptibility Patterns of Uropathogenic Escherichia Coli , With Special Reference to the Fluoroquinolones

Abstract

Context: The emergence of drug resistance to trimethoprimsulfamethoxazole, the penicillins, cephalosporins, and fluoroquinolones by Uropathogenic Escherichia coli (UPEC) has limited the options for selecting the appropriate antibiotic for the treatment of urinary tract infections. Aims:The The E. coli isolates, which were obtained from the culture of urine samples,were studied for their antibiotic resistance patterns, with special reference to the antimicrobial activity of the fluoroquinolones and the production of the extended spectrum ß-lactamases. (ESBL), Settings and Design: This was a hospital based, prospective study which was done for a period of eighteen months. Material and Methods:This study was done by using the standard culture techniques for urine samples, the modified Kirby-Bauer disk diffusion method for the antibiotic susceptibility testing and the disk diffusion method to confirm the ESBL production by the clinical isolates of E. coli in urine. The sensitivity pattern was correlated with the clinical condition and the presence of the risk factors.The statistical analysis which was used: The statistical analysis was done by using the proportions of sensitive, resistant and intermediates. Descriptive statistics like the total, mean and percentage were done by using the Statistical Package for the Social Sciences (SPSS), version 15.0. Results:The hospital isolates showed high degrees of resistance to the penicillins, cephalosporins, nalidixic acid and the fluoroquinolones, with 59% of the isolates being ESBL producers. Conclusions:The incidence of the multidrug resistant strains of Escherichia coli has been steadily increasing over the past few years. The knowledge on the resistance pattern of the bacterial strains in a geographical area will help in guiding the appropriate and the judicious use of antibiotics. Also, the formulation of an appropriate hospital antibiotic policy will go a long way in controlling these infections.Abdul RAhAmAn ShARiff V A, SuchitRA Shenoy m, tARunA yAdAV, RAdhAKRiShnA m

Prevalence of uropathogens and antimicrobial susceptibility profile in outpatient from Jataí-GO

“…Guajardo-Lara et al, in a study performed in Mexico, found 24.7% of resistance to ciprofloxacin (15) . Similar resistance percentage (23.5%) was also reported in India (26) .…”

“…An Indian study (26) showed E. coli prevalence of 48.3%; other studies showed prevalence of 71.3% in Turkey (1) and 77.5% in Belgium (3) . In the literature, data on other pathogens prevalence show large variation, while in this study, the most prevalent uropathogens, excepting E. coli, were S. saprophyticus (9.4%) and Proteus sp.…”

Patterns of Efflux Pump Genes Among Tetracycline Resistance Uropathogenic Escherichia coli Isolates Obtained From Human Urinary Infections

“…Escherichia coli is a facultative Gram-negative bacterium, which can cause many infections, like diarrhea, urinary tract infections, meningitis, peritonitis, and septicemia in humans (13). However, the most prevalent form of the extraintestinal infection caused by E. coli is urinary tract infection (14).…”

Detection and antibiotic susceptibility of pathogenicEscherichia coliisolated from the final effluent of two wastewater treatment Plants in the Eastern Cape Province, South Africa

“…It will help in directing the proper and the prudent utilization of antibiotics. The formulation of an appropriate institutional and organizational antibiotics policy will go a long way in controlling these infections (Shariff et al, 2013).…”

“…Broad range of antibiotics resistance encoding genes from microorganisms have been found in wastewater effluents, surface water, river water, groundwater and drinking water (Dolejska et al, 2011). Multi-drug resistance has been shown in E. coli (Shariff et al, 2013).…”