The antibiotic sensitivity pattern and the use of antibiotics in women with asymptomatic bacteriuria in pregnancy

Abstract

All the samples were assessed in the microbiology laboratory of the CSTH. Samples were cultured on Cystine Lactose Electrolyte Deficient (CLED) Agar medium and a colony count of more than 10 5 per ml of urine was taken as significant bacteriuria. The antibiotic sensitivity was assessed in accordance with Clinical and Abstract Key Words: Asymptomatic bacteriuria, Pregnancy, Nitrofurantoin Background: Nitrofurantoin has been recommended as a first line therapy in Sri Lanka for urinary tract infections in pregnancy but it is not used frequently Materials and Methods:At the Colombo South Teaching Hospital a descriptive cross sectional study was carried out from June 2015 to April 2016 on 98 consecutive pregnant women between eight to 24 weeks of gestation, residing in Colombo district and presenting with no urinary symptoms suggestive of urinary tract infection at the time of urine collection but having a positive urine culture (colony count of > 10 5 per ml of urine). The antibiotic sensitivity of the identified pathogens was studied. Results:The commonest organism found was Coliforms (n = 79) .The other organisms identified were Staphylococci (n = 10), Streptococci (n = 7) and Enterococci (n = 2). All the organisms were sensitive to Nitrofurantoin. However, Nitrofurantoin was used only in 57 women. Conclusion:As all the organisms were sensitive to Nitrofurantoin, prescribing practices need to be changed to include Nitrofurantoin as the first line of therapy for asymptomatic bacteriuria of pregnancy.

Phenotypic and Genotypic Characterization of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Asymptomatic Bacteriuria in Pregnancy

“…49 In the current study, imipenem and amikacin were the most active antibacterial agents (100%), which is consistent with previous studies. 50,51 Unfortunately, these antibiotics have limited use in pregnancy. 52 The least sensitive antibiotic was ampicillin ranging from 0% to 25% among both ESBL and non-ESBL-producing isolates.…”