The antibacterial activity of vanillin derivative compounds

Retnosari, Rini; Rachman, Ihsan Budi; Sutrisno, Sutrisno; Sari, Meyga Evi Ferama; Sukarianingsih, Dedek; Rukayadi, Yaya

doi:10.1063/5.0051523

Cited by 4 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, in some studies, vanillin was used in combination with other antimicrobial products, such as essential oils ( 27 ) and potassium sorbate ( 57 ). In a recent study, synthetic vanillin (5 mg/mL) exhibited robust antimicrobial activity against gram-negative as well as gram-positive bacteria, with zones of inhibition ranging from 11.67 to 12.75 ( 58 ) which is comparable to our results.…”

Section: Resultssupporting

confidence: 91%

Natural deep eutectic solvents-based green extraction of vanillin: optimization, purification, and bioactivity assessment

Xu,

Liaqat,

Khazi

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

The sustainable extraction of natural compounds has recently attracted significant attention. The extraction of high-quality natural vanillin in active form is crucial for its efficient use in various industries, but conventional solvents are not suitable for this purpose. The flammability, volatility, and toxicity of organic solvents can harm extraction personnel, and their waste liquid can cause environmental pollution. Natural deep eutectic solvents (NADES) are cost-effective, environmentally friendly, biodegradable, and non-toxic organic alternative to conventional solvents. In this study, 20 different NADES were tested for the sustainable extraction of natural vanillin. Among these, a DES system composed of choline chloride: 1,4-butanediol: lactic acid exhibited the highest extraction rate (15.9 mg/g). Employing response surface methodology (RSM), optimal extraction conditions were determined, yielding a vanillin content 18.5 mg/g with water content of 33.9%, extraction temperature of 64.6°C, extraction time of 32.3 min, and a solid-liquid ratio of 44.9 mg/mL. Subsequently, the optimized NADES system was then assessed for reusability in extracting vanillin from vanilla pods and kraft lignin over three cycles, retaining 43% of its extraction efficiency and demonstrating potential for waste reduction. Purification of vanillin was achieved through chromatography using a non-polar resin SP700, with ethanol as a desorption eluent and a feed solution pH of 4.0, resulting in the highest vanillin purity. HPLC and GC-MS analyses confirmed purity, while antioxidant activity assays (DPPH and ABTS) showcased significant antioxidant activity of the purified vanillin. Moreover, vanillin exhibited notable antimicrobial activity against a panel of food-borne bacteria. This study introduces an environmentally friendly approach to vanillin extraction highlights using NADES, emphasizing the potential for producing high-quality bioactive vanillin with reduced environmental impact. The applicability of NADES systems extends beyond vanillin, offering a versatile method for extracting diverse natural compounds.

show abstract

Section: Resultssupporting

confidence: 91%

Natural deep eutectic solvents-based green extraction of vanillin: optimization, purification, and bioactivity assessment

Xu,

Liaqat,

Khazi

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…, condensation. 45 With two methoxy groups, S-type compounds (syringaldehyde and 3,5-dimethoxy-4-hydroxyacetophenone) are more electron-rich than G-type compounds (vanillin and acetovanillone) and thus led to more condensation. Acetovanillone and 3,5-dimethoxy-4-hydroxyacetophenone could also undergo aldol condensation.…”

Section: Resultsmentioning

confidence: 99%

“…The carbonyl group can be protonated under the acidic conditions in ACLB, and the positively charged carbonyl carbon is vulnerable to attack by electron-rich aromatics (the nucleophile), resulting in the formation of new C-C bonds, i.e., condensation. 45 With two methoxy groups, S-type compounds (syringaldehyde and 3,5-dimethoxy-4-hydroxyacetophenone) are more electron-rich than G-type compounds (vanillin and acetovanillone) and thus led to more condensation. Acetovanillone and 3,5-dimethoxy-4-hydroxyacetophenone could also undergo aldol condensation.…”

Section: Demethylation Of Ps (S-type Aromatic) In Aclbmentioning

confidence: 99%