The antibacterial activity of poly(vinyl chloride) membrane impregnated with silver nanoparticles

Al-Himeiry, Asmaa N.; Al-Fatlawi, Alaa H.

doi:10.1016/j.matpr.2021.08.277

Cited by 2 publications

(5 citation statements)

References 11 publications

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“…So, the coumarin-chalcone hybrid series 4a-h were evaluated for their antimicrobial activity against human pathogenic bacteria and fungi according to the literature procedure. [38] The antimicrobial effects of 4a-h were compared with commercial antibiotics, Streptomycin (10 mcg/disc) and Tetracycline (30 mcg/disc) as antibacterial standard reference for bacteria. Clotrimazole (10 mcg/disc) and Fluconazole (25 mcg/disc) were used as antifungal standard reference for fungi.…”

Section: Antimicrobial Resultsmentioning

confidence: 99%

“…Therefore, hybridization of coumarin with other antibacterial pharmacophores may contribute to design of new antibiotics. So, the coumarin‐chalcone hybrid series 4a – h were evaluated for their antimicrobial activity against human pathogenic bacteria and fungi according to the literature procedure [38] . The antimicrobial effects of 4a – h were compared with commercial antibiotics, Streptomycin (10 mcg/disc) and Tetracycline (30 mcg/disc) as antibacterial standard reference for bacteria.…”

Section: Resultsmentioning

confidence: 99%

“…In order to determine the antimicrobial activity of the hybrid derivatives, Well Diffusion Method was used [38] . To prepare young cultures of microorganisms, Nutrient Broth (Oxoid) for bacteria and Malt Extract Broth (Oxoid) for fungi were used.…”

Section: Methodsmentioning

confidence: 99%

“…In order to determine the antimicrobial activity of the hybrid derivatives, Well Diffusion Method was used. [38] To prepare young cultures of microorganisms, Nutrient Broth (Oxoid) for bacteria and Malt Extract Broth (Oxoid) for fungi were used. After preparation according to 0.5 McFarland standardization, the plates were incubated at 30-35 °C for 24 and 48 h for bacteria and at 30 °C for 72 h for fungi.…”

Section: Antimicrobial Activity Assaymentioning

confidence: 99%

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Antimicrobial, Antiproliferative Effects and Docking Studies of Methoxy Group Enriched Coumarin‐Chalcone Hybrids

Musatat

Kılıçcıoğlu

Kurman

et al. 2023

Chemistry & Biodiversity

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Methoxy group enriched eight coumarin-chalcone hybrid derivatives were synthesized. Antimicrobial/ antiproliferative activities were tested against eight human pathogenic microorganisms and four cancer cell lines (AGS, HepG2, MCF-7 and PC-3), respectively. Antimicrobial results showed that most of the compounds were almost more active than used standard antibiotics. Cytotoxicity results showed that 2,3,4-trimethoxyphenyl and thiophene containing structures have promising antiproliferative effects against AGS gastric cell lines with ~5 μg/ml IC 50 values. At the same time, 2,4-dimethoxyphenyl bearing derivative exhibited the lowest IC 50 values against HepG2 (~10 μg/ml) and PC-3 (~5 μg/ml) cell lines. Particularly, the cell viabilities of MCF-7 cell lines were remarkably inhibited by all the compounds with lower IC 50 values. Therefore, molecular docking studies between hybrid ligands and quinone reductase-2 enzyme (regulates in MCF-7 cancer cells) were performed. The results demonstrated that all the derivatives can smoothly interact with interested enzyme in agreement with the experimental results. Finally, ADME parameters were studied to reveal drug-likeness potentials of the coumarinchalcone hybrids.

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Section: Antimicrobial Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Antimicrobial Activity Assaymentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial, Antiproliferative Effects and Docking Studies of Methoxy Group Enriched Coumarin‐Chalcone Hybrids

Musatat

Kılıçcıoğlu

Kurman

et al. 2023

Chemistry & Biodiversity

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show abstract

“…Incorporation of Ag NPs-modified chitosan into the polyacrylamide-gelatin network and coating the nanocomposite on the surface of PVC was shown to be promising to prevent biofilm-related infections in the endotracheal tube which is an essential medical device to secure the airway patency in patients undergoing mechanical ventilation or general anesthesia [ 170 ]. Composites of PVC with other nanoparticles such as CuO NPs [ 171 ], Ag NPs [ [172] , [173] , [174] ], ZnO NPs [ 175 , 176 ], modified SiO 2 nanoparticles [ 177 ], silver phosphate NPs [ 178 ] gold NPs [ 179 ], Cu NPs [ 180 ], and SiO 2 –Ag [ 181 ] have shown antibacterial activities. In the context of PVC-clay nanocomposites, clay enhances the antibacterial drug loading through electrostatic attraction and intercalation of the drug within its layers.…”

Section: Applications Of Pvc-clay Composite and Nanocompositementioning

confidence: 99%