“…Frequent references are found in the literature emphasizing the synergistic or antagonistic effect of a particular substance upon the biological activity of other, chemically unrelated compounds. In the case of the germicides, it has been shown by Domagk (1935), Baker, Harrison, and Miller (1941), Valko and DuBois (1944), and many others that cationic and anionic detergents will neutralize each other. Such reversal of the activity of quaternary ammonium compounds have been demonstrated with soaps, sodium taurochoate, sodium lauryl sulfate, suramin sodium and many other anionic agents.…”