The antiatherogenic, renal protective and immunomodulatory effects of purslane, pumpkin and flax seeds on hypercholesterolemic rats

Barakat, Lamiaa; Mahmoud, Rasha

doi:10.4297/najms.2011.3411

Cited by 55 publications

(38 citation statements)

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“…The major total fatty acids present in rice bran oil and pumpkin oil are unsaturated fatty acids such as oleic acid and linoleic acid [Chopra & Sambaiah, 2009; Al-Okbi et al, in press]. These unsaturated fatty acids play a crucial role in reducing blood cholesterol in humans and rats [Barakat & Mahmoud, 2011] which might be related to reduction of cholesterol synthesis and/or increased cholesterol catabolism in the liver.…”

Section: Discussionmentioning

confidence: 99%

Rice Bran Oil and Pumpkin Seed Oil Alleviate Oxidative Injury and Fatty Liver in Rats Fed High Fructose Diet

Al‐Okbi¹,

Mohamed²,

Hamed³

et al. 2014

Pol. J. Food Nutr. Sci.

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Key words: fatty liver, non-alcoholic fatty liver with infl ammation, fructose, rice bran oil, pumpkin seed oil Nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease are increasing in adults and are likely to be increasing in children. The aim of the present research was to evaluate the protective effect of rice bran oil and pumpkin seed oil against high fructose diet (HFD) inducing nonalcoholic steatohepatitis (NASH). The results showed signifi cant elevation of plasma total and direct bilirubin, transaminases activities, total cholesterol (T-Ch), triglycerides (TG), low density lipoprotein-cholesterol (LDL-Ch), tumor necrosis factor- (TNF-) and malondialdehyde (MDA) with signifi cant increase in liver TG, T-Ch and MDA along with signifi cant reduction in plasma high density lipoprotein cholesterol (HDL-Ch) and increase in T-Ch/HDL-Ch in rats fed HFD compared to rats fed on balanced diet. Histopathology of liver of rats fed on HFD confi rmed the induction of NASH. Rice bran oil and pumpkin seed oil produced improvement in the biochemical parameters with different degrees. Pumpkin seed oil reversed all histopathological changes that occur in liver tissue which became comparable to normal in some rats. In conclusion, rats fed high fructose diet are a good model for studying NASH. Rice bran oil and pumpkin seed oil afford hepato protection against NASH in rat model.

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Section: Discussionmentioning

confidence: 99%

Rice Bran Oil and Pumpkin Seed Oil Alleviate Oxidative Injury and Fatty Liver in Rats Fed High Fructose Diet

Al‐Okbi¹,

Mohamed²,

Hamed³

et al. 2014

Pol. J. Food Nutr. Sci.

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“…Furthermore, there are other plants act as natural antioxidant that are reported to management the obesity and reduce the risks associated such as Pistachio, Psylliumfibre, black Chinese tea, sea buckthorn and bilberries. The effect of purslane seeds intake in reducing body weight might be due to insulin resistance [167]. Some documents have also attributed the lipolytic effect of purslane to its content of nor-adrenaline [168].…”

Section: Therapeutic Benefits Of Purslanementioning

confidence: 99%

“…The effect of purslane intake on lowering serum triglyceride levels might be explained by its high content of omega-3 fatty acids and fiber [173]. Also, purslaneseed mixture rich in polyunsaturated fatty acids had a strong hypolipidemic, hypotriglyceridemic and hypocholesterolemic effects in plasma and liver of rats with a reduction of plasma LDL-C levels and an increase in HDL-C levels [167].Moreover, the dietary fiber could be promoting the elimination of bile, the lack of bile in body could be reproduced from dietary cholesterol and then the level of serum cholesterol could be decrease [174].…”

Section: Therapeutic Benefits Of Purslanementioning

confidence: 99%

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Hassan

El-Gharib

2015

Appl Biochem Biotechnol

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Obesity is a global health problem affecting all age groups, leading to many complications such as type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, atherosclerosis, and stroke. Physiologically, obesity arises from metabolic changes in the tissues and organs of the human body; these changes result in an imbalance between energy intake and energy expenditure, which in turn results in increased fat accumulation in adipose tissue. Such fat accumulation predisposes individuals to development of several health problems. Two different obesity treatment drugs are currently on the market; Orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase, and Sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. Therefore, the present review focuses on the safety and efficacy of some herbal medicines in the management of obesity through covering their beneficial effects and mechanism of action.

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“…Arterial hypertension is among the most frequent pathologies in elderly worldwide, with an incidence ranging from 40 % (about 65 years patients) to 90 % (patients older than 85) in developed countries [1, 2]. This pathology raises more concerns as it constitutes a major risk of cardiovascular accident.…”

Section: Introductionmentioning

confidence: 99%

Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

Ntchapda

Berthou

Azambou

et al. 2016

BMC Complement Altern Med

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Background Vepris heterophylla (Rutaceae) is a medicinal plant used empirically in African traditional medicine for many clinical conditions including edematous disorders and hypertension. V. heterophylla aqueous extract has been used in northern part of Cameroon by traditional healers for the treatment of arterial hypertension. The study aim was to assess the putative diuretic and antioxidant properties of V. heterophylla leaves aqueous extract.MethodsAdult rats were administered with V. heterophylla leaves aqueous extract acutely (24 h) at doses 50, 100, 150, 200 and 250 mg/kg (per os). The two positive control groups received the diuretic drugs furosemide (5 mg/kg) and hydrochlorothiazide (HCTZ, 10 mg/kg), while negative control group received only an equivalent volume of distilled water. Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed.ResultsThe findings indicated that the aqueous extract of V. heterophylla at doses ranging from 150 to 250 mg/kg caused a significant and dose-dependent increase of urinary water and electrolytes excretion in normal rats. The aqueous extract of the leaves of V. heterophylla accelerated the elimination of overloaded fluid. At the maximum of diuretic response, urinary osmolarity decreased significantly when compared with controls. Oral administration of aqueous extract at different doses produced a significant diuresis and slight increase in electrolytes (Na+, K+ and Cl−) excretion. The results obtained were compared with standard drug-furosemide (5 mg/kg) and hydrochlorothiazide (10 mg/kg). These effects were observed predominantly at 250 mg/kg dose.ConclusionsOur findings strongly suggest that V. heterophylla aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension.

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The antiatherogenic, renal protective and immunomodulatory effects of purslane, pumpkin and flax seeds on hypercholesterolemic rats

Cited by 55 publications

References 0 publications

Rice Bran Oil and Pumpkin Seed Oil Alleviate Oxidative Injury and Fatty Liver in Rats Fed High Fructose Diet

Rice Bran Oil and Pumpkin Seed Oil Alleviate Oxidative Injury and Fatty Liver in Rats Fed High Fructose Diet

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Diuretic and antioxidant activities of the aqueous extract of leaves of Vepris heterophylla (Engl.) R. Let (Rutaceae) in rats

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