The Antiangiogenic and Antinociceptive Activities of <i>n</i>‐Propyl Gallate

Jung, Hyejin; Cj, Lim

doi:10.1002/ptr.3452

Cited by 13 publications

(2 citation statements)

References 18 publications

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“…It received much attention because of its potent property of scavenging reactive oxygen species (ROS), like superoxide anions, hydrogenperoxide (H 2 O 2 ), hydroxyl radicals (OH·) and hypochlorous acid (HOCl), ameliorating oxidative stress, especially heavy metal-induced oxidative stress [[2], [3], [4], [5]]. Already the anti-diabetic, anti-bacterial, anti-infammatory, anti-angiogenic, anti-oxidant, and anti-cancer activity of GA has been reported [[6], [7], [8], [9], [10]]. Furthermore, the neuro-protective effect of GA in rats has been established [11].…”

Section: Introductionmentioning

confidence: 99%

Gallic acid protects rat liver mitochondria ex vivo from bisphenol A induced oxidative stress mediated damages

Dutta

Paul

2019

Toxicology Reports

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Highlights Bisphenol A induces oxidative stress mediated liver mitochondrial damage. Bisphenol A induced damage is being protected when mitochondria are co-incubated with gallic acid. Scanning electron microscopy of mitochondrial tomography supports the biochemical observations. Gallic acid may be used as future remedial measure for the protection of bisphenol A induced damages of liver mitochondria.

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Section: Introductionmentioning

confidence: 99%

Gallic acid protects rat liver mitochondria ex vivo from bisphenol A induced oxidative stress mediated damages

Dutta

Paul

2019

Toxicology Reports

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“…For example, DABCO, used as an antifading agent in fluorescence microscopy and as a stabilizer of dye lasers, likely exerts its actions by a combination of triplet state and singlet oxygen quenching (3,63,64). The antioxidant nPG has been shown to slow photobleaching in fluorescence microscopy applications (2,(65)(66)(67), including live cell studies (68)(69)(70)(71). TX, which initially was thought to function as an antioxidant and has been widely employed as an antioxidant in different cell treatments (72)(73)(74)(75), partly degrades to form a quinone derivative (58).…”

Section: Discussionmentioning

confidence: 99%

Small-Molecule Photostabilizing Agents are Modifiers of Lipid Bilayer Properties

Alejo

Blanchard

Andersen

2013

Biophysical Journal

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Small-molecule photostabilizing or protective agents (PAs) provide essential support for the stability demands on fluorescent dyes in single-molecule spectroscopy and fluorescence microscopy. These agents are employed also in studies of cell membranes and model systems mimicking lipid bilayer environments, but there is little information about their possible effects on membrane structure and physical properties. Given the impact of amphipathic small molecules on bilayer properties such as elasticity and intrinsic curvature, we investigated the effects of six commonly used PAs--cyclooctatetraene (COT), para-nitrobenzyl alcohol (NBA), Trolox (TX), 1,4-diazabicyclo[2.2.2]octane (DABCO), para-nitrobenzoic acid (pNBA), and n-propyl gallate (nPG)--on bilayer properties using a gramicidin A (gA)-based fluorescence quench assay to probe for PA-induced changes in the gramicidin monomer↔dimer equilibrium. The experiments were done using fluorophore-loaded large unilamellar vesicles that had been doped with gA, and changes in the gA monomer↔dimer equilibrium were assayed using a gA channel-permeable fluorescence quencher (Tl⁺). Changes in bilayer properties caused by, e.g., PA adsorption at the bilayer/solution interface that alter the equilibrium constant for gA channel formation, and thus the number of conducting gA channels in the large unilamellar vesicle membrane, will be detectable as changes in the rate of Tl⁺ influx-the fluorescence quench rate. Over the experimentally relevant millimolar concentration range, TX, NBA, and pNBA, caused comparable increases in gA channel activity. COT, also in the millimolar range, caused a slight decrease in gA channel activity. nPG increased channel activity at submillimolar concentrations. DABCO did not alter gA activity. Five of the six tested PAs thus alter lipid bilayer properties at experimentally relevant concentrations, which becomes important for the design and analysis of fluorescence studies in cells and model membrane systems. We therefore tested combinations of COT, NBA, and TX; the combinations altered the fluorescence quench rate less than would be predicted assuming their effects on bilayer properties were additive. The combination of equimolar concentrations of COT and NBA caused minimal changes in the fluorescence quench rate.

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Characterization of Bioimprinted Tannase and Its Kinetic and Thermodynamics Properties in Synthesis of Propyl Gallate by Transesterification in Anhydrous Medium

Nie

Zheng

Gong

et al. 2012

Appl Biochem Biotechnol

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Tannase has been extensively applied to synthesize gallic acid esters. Bioimprinting technique can evidently enhance transesterification-catalyzing performance of tannase. In order to promote the practical utilization of the modified tannase, a few enzymatic characteristics of the enzyme and its kinetic and thermodynamics properties in synthesis of propyl gallate by transesterification in anhydrous medium have been studied. The investigations of pH and temperature found that the imprinted tannase holds an optimum activity at pH 5.0 and 40 °C. On the other hand, the bioimprinting technique has a profound enhancing effect on the adapted tannase in substrate affinity and thermostability. The kinetic and thermodynamic analyses showed that the modified tannase has a longer half-time of 1,710 h at 40 °C; the kinetic constants, the activation energy of reversible thermal inactivation, and the activation energy of irreversible thermal inactivation, respectively, are 0.054 mM, 17.35 kJ mol(-1), and 85.54 kJ mol(-1) with tannic acid as a substrate at 40 °C; the free energy of Gibbs (ΔG) and enthalpy (ΔH) were found to be 97.1 and 82.9 kJ mol(-1) separately under the same conditions.

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The Antiangiogenic and Antinociceptive Activities of n‐Propyl Gallate

Cited by 13 publications

References 18 publications

Gallic acid protects rat liver mitochondria ex vivo from bisphenol A induced oxidative stress mediated damages

Gallic acid protects rat liver mitochondria ex vivo from bisphenol A induced oxidative stress mediated damages

Small-Molecule Photostabilizing Agents are Modifiers of Lipid Bilayer Properties

Characterization of Bioimprinted Tannase and Its Kinetic and Thermodynamics Properties in Synthesis of Propyl Gallate by Transesterification in Anhydrous Medium

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