The Anti-Virulence Effect of Vismia guianensis against Candida albicans and Candida glabrata

Motta, Elizangela Pestana; Farias, Josivan Regis; Costa, Arthur André Castro da; Silva, Anderson França da; Lopes, Alberto Jorge Oliveira; Cartágenes, Maria do Socorro Sousa; Nicolete, Roberto; Abreu, Afonso G.; Fernandes, Elizabeth S.; Nascimento, Flávia R.F.; Rocha, Cláudia Quintino da; Monteiro, Cristina de Andrade; Guerra, Rosane Nassar Meireles

doi:10.3390/antibiotics11121834

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…been used to treat skin diseases, such as herpes, dermatitis, leprosy, syphilis, scabies and eczema, among others [4,[9][10][11][12].…”

Section: Original Research Articlementioning

confidence: 99%

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Chemical Composition and Antibacterial activity of Essential Oils from Fruits of Vismia baccifera and Vismia macrophylla Collected at different Locations in Venezuelan Andes

Buitrago,

Rojas,

Velasco

et al. 2023

EJMP

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Background: Genus Vismia (Hipericaceae/Clusiaceae) is distributed mainly in tropical and subtropical areas of Central America and South America although some species have been reported in Africa as well. Species of this genus have been used in traditional medicine to alleviate different ailments such as skin infections, to treat urinary tract disorders, as antirrheumatic, antipyretic, among others. Previous investigations have revealed that species from Vismia genus are composed mainly of terpenes, anthrones, lignans, flavonoids, anthraquinones, steroids and xanthones. The purpose of the investigation was to determine the chemical composition and antimicrobial activity of essential oils from the fruits of V. baccifera and V. macrophylla collected in Venezuelan Andes. Methods: Vimia species were collected at different locations in Mérida and Táchira state, Venezuela. Essential oils were obtained through Hidrodistilation and chemical compositon was performed by GC and GC/MS techniques. Antimicrobial analysis was carried out by disc diffusion assays. Results: GC and GC/MS analysis showed that these species are mainly composed of sesquiterpenes being α-curcumene, β-curcumene, germacrene D, γ-bisabolene and β-caryophyllene among the major components. Antimicrobial activity was also performed with species under investigation. Results showed a broad spectrum of activity since both species were able to inhibit not only Gram- positive (Stpahylococcus aureus, Enterococcus faecalis) and Gram-negative bacterial strains (Escherichia coli, Pseudomonas aeruginosa) but yeast (Candida albicans and Candida krusei) as well. Conclusions: According to the results observed in the investigation, Vismia species might be considered as an alternative to aid infectious diseases.

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“…been used to treat skin diseases, such as herpes, dermatitis, leprosy, syphilis, scabies and eczema, among others [4,[9][10][11][12].…”

Section: Original Research Articlementioning

confidence: 99%

“…Afrovismia, which includes the African species" [5]. "In Venezuela 17 species of Vismia have been located being Vismia baccifera Triana & Planch and Vismia macrophylla Kunth the most common and well-distributed around the country" [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial activity of Essential Oils from Fruits of Vismia baccifera and Vismia macrophylla Collected at different Locations in Venezuelan Andes

Buitrago,

Rojas,

Velasco

et al. 2023

EJMP

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“…Finally, the study highlights the importance of P. granatum as a source of antimicrobials and the need for further studies with the tannin identified in the study. In another report by Motta et al [ 5 ], C. albicans and C. glabrata were incubated with the hydroalcoholic extract from the leaves of Vismia guianensis , a native Brazilian plant. The extract showed antifungal and fungicidal activities against Candida sp., inhibiting fungi growth and adhesion, as well as disrupting both early and mature biofilms.…”

mentioning

confidence: 99%

Antimicrobial and Anti-Infective Activity of Natural Products—Gaining Knowledge from Novel Studies

Fernandes

Figueiredo²,

Monteiro

et al. 2023

Antibiotics

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Despite advances in the development of antimicrobial drugs in the last centuries, antimicrobial resistance has consistently raised in the last decades, compromising their effectiveness. Novel antimicrobial compounds, especially from natural sources, including plants, microorganisms, and animals, have since become a growing area of research. In this context, studies covering the investigation of their ability to combat resistant microorganisms, either by neutralization or inactivation of pathogen resistance mechanisms and virulence properties, have gained attention. Herein, a collection of 19 manuscripts focused on the antimicrobial and anti-infective activity of natural products, including their mechanisms of action, in silico evidence of antimicrobial activity, synergistic associations with antibiotics, and other aspects, will be discussed.

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Synthesis of Antimicrobial Chitosan-Silver Nanoparticles Mediated by Reusable Chitosan Fungal Beads

Hermosilla

Díaz

Vera

et al. 2023

IJMS

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Nanoparticles, especially silver nanoparticles (Ag NPs), have gained significant attention in recent years as potential alternatives to traditional antibiotics for treating infectious diseases due to their ability to inhibit the growth of microorganisms effectively. Ag NPs can be synthesized using fungi extract, but the method is not practical for large-scale production due to time and biomass limitations. In this study, we explore the use of chitosan to encapsulate the mycelia of the white-rot fungus Stereum hirsutum and form chitosan fungal beads for use in multiple extractions and nanoparticle synthesis. The resulting nanoparticles were characterized using various techniques, including UV-vis spectrophotometry, transmission electron microscopy, dynamic light scattering, and X-ray diffraction analysis. The analysis revealed that the synthesized nanoparticles were composed of chitosan-silver nanoparticles (CS-Ag NPs) with a size of 25 nm. The chitosan fungal beads were reused in three extractions and nanoparticle synthesis before they lost their ability to produce CS-Ag NPs. The CS-Ag NPs showed potent antimicrobial activity against phytopathogenic and human pathogenic microorganisms, including Pseudomonas syringae, Escherichia coli, Staphylococcus aureus, and Candida albicans, with minimum inhibitory concentrations of 1.5, 1.6, 3.1, and 4 µg/mL, respectively. The antimicrobial activity of CS-Ag NPs was from 2- to 40-fold higher than Ag NPs synthesized using an aqueous extract of unencapsulated fungal biomass. The CS-Ag NPs were most effective at a pH of five regarding the antimicrobial activity. These results suggest that the chitosan fungal beads may be a promising alternative for the sustainable and cost-effective synthesis of CS-Ag NPs with improved antimicrobial activity.

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The Anti-Virulence Effect of Vismia guianensis against Candida albicans and Candida glabrata

Cited by 3 publications

References 40 publications

Chemical Composition and Antibacterial activity of Essential Oils from Fruits of Vismia baccifera and Vismia macrophylla Collected at different Locations in Venezuelan Andes

Chemical Composition and Antibacterial activity of Essential Oils from Fruits of Vismia baccifera and Vismia macrophylla Collected at different Locations in Venezuelan Andes

Antimicrobial and Anti-Infective Activity of Natural Products—Gaining Knowledge from Novel Studies

Synthesis of Antimicrobial Chitosan-Silver Nanoparticles Mediated by Reusable Chitosan Fungal Beads

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