The anti-tumor activity of novel oxovanadium complexes derived from thiosemicarbazones and fluoro-phenanthroline derivatives

Rui, Wen; Tian, Xiaoli; Zeng, Pengfei; Liu, Weimin; Ying, Peng; Chen, Hongce; Lu, Jiazheng; Yang, Ning

doi:10.1016/j.poly.2016.07.021

Cited by 18 publications

(10 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other research, DNA melting and comet assay studies suggested the formation of DNA crosslinks by terpyridyl oxidovanadium(IV) complexes (28 and 29), and this effect was observed upon irradiation with visible light [37]. Additionally, neutral oxidovanadium(V) complexes with different organic ligands (30)(31)(32)(33) had DNA binding propensity and it was shown that these interacted with CT-DNA through minor groove binding mode; however, the complex with isonicotinoylhydrazone of 2-hydroxy acetophenone (32) showed the highest photo-induced DNA cleavage activity [38].…”

Section: Dna: the Classical Targetmentioning

confidence: 89%

“…The DNA interaction ability has been determined also for the phenantroline vanadium complex (7-10) with simultaneous cytotoxic activity against human ovarian and breast carcinoma cells [29]. Furthermore, Rui et al [30] has shown that vanadium complexes derived from thiosemicarbazones and fluoro-phenanthroline derivatives (11)(12)(13) interacted with calf-thymus DNA (CT-DNA) through a non-classical intercalative mode and they could efficiently cleavage plasmid pBR322 DNA upon exposure to ultraviolet light. Additionally, all investigated complexes exhibited anti-proliferative activity against many human tumor cell lines [30].…”

Section: Dna: the Classical Targetmentioning

confidence: 99%

“…Furthermore, Rui et al [30] has shown that vanadium complexes derived from thiosemicarbazones and fluoro-phenanthroline derivatives (11)(12)(13) interacted with calf-thymus DNA (CT-DNA) through a non-classical intercalative mode and they could efficiently cleavage plasmid pBR322 DNA upon exposure to ultraviolet light. Additionally, all investigated complexes exhibited anti-proliferative activity against many human tumor cell lines [30]. A similar study has been performed for oxidovanadium(IV) phenanthroimidazole derivatives (14)(15)(16)(17), which could bind with CT-DNA and which cleaved supercoiled plasmid DNA in the presence of H 2 O 2 , and also exhibited cytotoxicity against a cervical cancer cell line by inducing apoptosis [31].…”

Section: Dna: the Classical Targetmentioning

confidence: 99%

“…breast cancer cells MCF-7 (7: IC50 53 ± 2.0 µM 8: IC50 77 ± 1.3 µM 9: IC50 95 ± 3.7 µM 10: IC50 68 ± 1.4 µM) [29] Interaction with CT-DNA through a nonclassical intercalative mode cleavage plasmid pBR322 DNA upon exposure to ultraviolet light Cytotoxicity (48 h): panel of cervical, breast and esophageal cancer cells IC50 range: 0.31-6.15 µM [30] Similarities to cisplatin concerning DNA interaction ROS generation, mitochondrial damage, G 2 /M cell cycle arrest Cytotoxicity (72 h): panel of melanoma, colon, cervical, breast and pancreatic cancer cells Phen-containing V IV O compounds display stronger DNA interaction ability than the corresponding bipy analogues Cytotoxicity (72 h): ovarian cancer cells A2780 (7: IC50 20.8 ± 0.5 µM 8: IC50 4.9 ± 1.3 µM 9: IC50 17.1 ± 3.9 µM 10: IC50 4.7 ± 1.8 µM)…”

Section: Dna: the Classical Targetmentioning

confidence: 99%

See 3 more Smart Citations

Molecular and Cellular Mechanisms of Cytotoxic Activity of Vanadium Compounds against Cancer Cells

2020

View full text Add to dashboard Cite

Discovering that metals are essential for the structure and function of biomolecules has given a completely new perspective on the role of metal ions in living organisms. Nowadays, the design and synthesis of new metal-based compounds, as well as metal ion binding components, for the treatment of human diseases is one of the main aims of bioinorganic chemistry. One of the areas in vanadium-based compound research is their potential anticancer activity. In this review, we summarize recent molecular and cellular mechanisms in the cytotoxic activity of many different synthetic vanadium complexes as well as inorganic salts. Such mechanisms shall include DNA binding, oxidative stress, cell cycle regulation and programed cell death. We focus mainly on cellular studies involving many type of cancer cell lines trying to highlight some new significant advances.

show abstract

Section: Dna: the Classical Targetmentioning

confidence: 89%

Section: Dna: the Classical Targetmentioning

confidence: 99%

Section: Dna: the Classical Targetmentioning

confidence: 99%

Section: Dna: the Classical Targetmentioning

confidence: 99%

See 2 more Smart Citations

Molecular and Cellular Mechanisms of Cytotoxic Activity of Vanadium Compounds against Cancer Cells

2020

View full text Add to dashboard Cite

show abstract

“…In addition to this, metal complexes with diimine moieties have demonstrated potential in vitro anticancer activity with strong interaction and also capable to be exploited as DNA-targeted anticancer drug. 10,11 Based on these observations, the present study was undertaken to synthesize and characterize new thiosemicarbazone-based copper(II) complexes derived from (E)-N-methyl-2-(1-phenyl-2--((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)ethylidene) hydrazine carbothioamide H(L1), (E)-N-ethyl-2-(1-phenyl-2-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3--yl)thio)ethylidene)hydrazine carbothioamide H(L2) and (E)-N-phenyl-2-(1--phenyl-2-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)ethylidene)hydrazinecarbo-324 RAJENDRAN et al DNA Cleavage activity. The DNA cleavage efficiency of the thiosemicarbazone ligands and their copper(II) complexes were assessed by agarose gel electrophoresis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and efficacy of copper(II) complexes bearing N(4)-substituted thiosemicarbazide and diimine co-ligands on plasmid DNA and HeLa cell lines

Rajendran¹,

Periyasamy²,

Kamatchi

et al. 2020

JSCS

View full text Add to dashboard Cite

This present work deals with the synthesizes of nine novel thiosemicarbazone copper(II) complexes {[Cu(L) 2 ]Cl C3, [Cu(L)(bpy)]Cl C4-C6, [Cu(L) (phen)]Cl C7-C9 (where, L = H(L1)-H(L3), H(L1) = (E)-N-methyl-2-(1-phenyl-2-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)ethylidene)hydrazinecarbothioamide, H(L2) = (E)-N-ethyl-2-(1-phenyl-2-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)ethylidene) hydrazinecarbothioamide, H(L3) = (E)-N-phenyl-2-(1-phenyl-2-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)ethylidene) hydrazinecarbothioamide, bpy = 2,2′-bipyridyl and phen = 1,10-phenanthroline) with improved pharmacological results. The synthesized complexes were characterized by various spectral-analytical techniques. The structure of the copper(II) complexes C1-C9 was proposed by EPR spectroscopy. It confirmed the square planar coordination around Cu(II) complexes. The antibacterial screening of the complexes revealed that complexes C7 and C8 demonstrated significant activity against Gram-positive (B. thuringiensis) and Gram-negative (E. coli) bacteria. The concentration-dependent DNA cleavage activity of supercoiled (SC) pUC18 DNA exhibited complete DNA degradation effect on complex C6 at a minimum concentration of 40 μM. In vitro cytotoxic results showed that the mixed ligand copper(II) complexes C4, C5 and C7 exhibited higher effects on human cervical cancer cell lines, HeLa, when compared to cisplatin. Hence, the results obtained from each biological screening indicated the superior biological efficacy of the mixed ligand copper(II) complexes bearing diimine moieties. It could be considered as a promising alternative to an existing anticancer drug.

show abstract

Ni(II) and Cu(II) complexes of bidentate thiosemicarbazone ligand: Synthesis, structural, theoretical, biological studies and molecular modeling

Jain¹,

Sharma²,

Kumar³

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

The conventional condensation and refluxing process was employed to synthesize Ni(II) and Cu(II) complexes of Methylcarbamatethiosemicarbazone ligand. Reactions were carried out at the pH of 7. The molar ratio of the ligand and metal salt was 2:1. The structures of the synthesized metal complexes were suggested by different analytical techniques such as magnetic susceptibility, molar conductance, IR, EPR and UV spectroscopy. Experimental studies confirmed the octahedral geometry for all the complexes. The geometry of the ligand and complexes were also confirmed by theoretical studies. The complexes were investigated for biological action against pathogenic fungi (C. krusei, C. albican) and bacteria (S. aureus, E. coli). The antimicrobial results confirmed superior inhibition potential of the metal complexes as compared with the parent ligand. The enhanced antimicrobial activities might be due to the chelation. Molecular‐docking assays confirmed the strong interaction of ligand with target antimicrobial protein DNA gyrase‐B.

show abstract

The anti-tumor activity of novel oxovanadium complexes derived from thiosemicarbazones and fluoro-phenanthroline derivatives

Cited by 18 publications

References 46 publications

Molecular and Cellular Mechanisms of Cytotoxic Activity of Vanadium Compounds against Cancer Cells

Molecular and Cellular Mechanisms of Cytotoxic Activity of Vanadium Compounds against Cancer Cells

Synthesis and efficacy of copper(II) complexes bearing N(4)-substituted thiosemicarbazide and diimine co-ligands on plasmid DNA and HeLa cell lines

Ni(II) and Cu(II) complexes of bidentate thiosemicarbazone ligand: Synthesis, structural, theoretical, biological studies and molecular modeling

Contact Info

Product

Resources

About