The Anti-Proliferative Effects of Enterolactone in Prostate Cancer Cells: Evidence for the Role of DNA Licencing Genes, mi-R106b Cluster Expression, and PTEN Dosage

McCann, Mark J.; Rowland, Ian; Roy, Nicole C.

doi:10.3390/nu6114839

Cited by 25 publications

(16 citation statements)

References 46 publications

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“…31 Both in vitro and clinical studies have suggested that a diet rich in precursors of mammalian lignans (e.g., whole grain rye, bran or flaxseed) may have antiproliferative effects in the early stages of prostate cancer development. [37][38][39] However, findings from the current study do not support the hypothesis that circulating lignans play a role in the aetiology of prostate cancer.…”

Section: Discussioncontrasting

confidence: 99%

Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta‐analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls

Pérez-Cornago

Appleby

Boeing

et al. 2018

Intl Journal of Cancer

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Phytoestrogens may influence prostate cancer development. This study aimed to examine the association between prediagnostic circulating concentrations of isoflavones (genistein, daidzein, equol) and lignans (enterolactone and enterodiol) and the risk of prostate cancer. Individual participant data were available from seven prospective studies (two studies from Japan with 241 cases and 503 controls and five studies from Europe with 2,828 cases and 5,593 controls). Because of the large difference in circulating isoflavone concentrations between Japan and Europe, analyses of the associations of isoflavone concentrations and prostate cancer risk were evaluated separately. Prostate cancer risk by study‐specific fourths of circulating concentrations of each phytoestrogen was estimated using multivariable‐adjusted conditional logistic regression. In men from Japan, those with high compared to low circulating equol concentrations had a lower risk of prostate cancer (multivariable‐adjusted OR for upper quartile [Q4] vs. Q1 = 0.61, 95% confidence interval [CI] = 0.39–0.97), although there was no significant trend (OR per 75 percentile increase = 0.69, 95 CI = 0.46–1.05, p trend = 0.085); Genistein and daidzein concentrations were not significantly associated with risk (ORs for Q4 vs. Q1 = 0.70, 0.45–1.10 and 0.71, 0.45–1.12, respectively). In men from Europe, circulating concentrations of genistein, daidzein and equol were not associated with risk. Circulating lignan concentrations were not associated with the risk of prostate cancer, overall or by disease aggressiveness or time to diagnosis. There was no strong evidence that prediagnostic circulating concentrations of isoflavones or lignans are associated with prostate cancer risk, although further research is warranted in populations where isoflavone intakes are high.

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Section: Discussioncontrasting

confidence: 99%

Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta‐analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls

Pérez-Cornago

Appleby

Boeing

et al. 2018

Intl Journal of Cancer

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“…Furthermore, miR‐1825, which was also downregulated by resveratrol in our study, was recently shown to be promising as a potential urinary miRNA biomarker candidate for the detection of prostate cancer among benign prostatic hyperplasia patients . Remarkably, miR‐106b, which was downregulated by resveratrol in our microarray studies and was validated functionally, was found to be compellingly oncogenic in nine available prostate cancer reports . Studies validated the functional involvement of miR‐106b in regulation of genes encoding important cancer‐related proteins, such as PTEN, REST, E2F1, p21, and CASP7 .…”

Section: Role Of Resveratrol‐ and Resveratrol Analog–regulated Mirnassupporting

confidence: 74%

“…Studies validated the functional involvement of miR‐106b in regulation of genes encoding important cancer‐related proteins, such as PTEN, REST, E2F1, p21, and CASP7 . In addition, changes in miR‐106b levels have been reported in response to metformin, enterolactone, and radiation . However, the role of several resveratrol‐regulated miRNAs that have been implicated in prostate cancer pathophysiology is controversial.…”

Section: Role Of Resveratrol‐ and Resveratrol Analog–regulated Mirnasmentioning

confidence: 95%

Resveratrol and pterostilbene as a microRNA‐mediated chemopreventive and therapeutic strategy in prostate cancer

Kumar

Rimando

Levenson

2017

Annals of the New York Academy of Sciences

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Growing evidence indicates that deregulation of the epigenetic machinery comprising the microRNA (miRNA) network is a critical factor in the progression of various diseases, including cancer. Concurrently, dietary phytochemicals are being intensively studied for their miRNA-mediated health-beneficial properties, such as anti-inflammatory, cardioprotective, antioxidative, and anticancer properties. Available experimental data have suggested that dietary polyphenols may be effective miRNA-modulating chemopreventive and therapeutic agents. Moreover, noninvasive detection of changes in miRNA expression in liquid biopsies opens enormous possibilities for their clinical utilization as novel prognostic and predictive biomarkers. In our published studies, we identified resveratrol-regulated miRNA profiles in prostate cancer. Resveratrol downregulated the phosphatase and tensin homolog (PTEN)-targeting members of the oncogenic miR-17 family of miRNAs, which are overexpressed in prostate cancer. We have functionally validated the miRNA-mediated ability of resveratrol and its potent analog pterostilbene to rescue the tumor suppressor activity of PTEN in vitro and in vivo. Taken together, our findings implicate the use of resveratrol and its analogs as an attractive miRNA-mediated chemopreventive and therapeutic strategy in prostate cancer and the use of circulating miRNAs as potential predictive biomarkers for clinical development.

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“…The plant is rich in carvacrol, a phenolic monoterpene with recognized anti-inflammatory and antitumor properties (Burts & al. 2007;McCann & al. 2014).…”

Section: Introductionmentioning

confidence: 99%

Solunto archaeological park in Sicily: life under mosaic tesserae

2018

Fl. Medit.

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Rotolo, V., De Caro, M. L., Giordano, A. & Palla, F.: Solunto archaeological park in Sicily: life under mosaic tesserae. -Fl. Medit. 28: 233-245. 2018. -ISSN: 1120-4052 printed, 2240-4538 online.Biodeterioration is a complex process induced by the growing and metabolic activity of a wide range of macro and microorganisms, becoming a revelling problem also for the mosaic tesserae of "Casa di Leda" in the Greco -Roman site of Solunto in Sicily. In this case-study, a thick biofilm inducing a deep alteration of mortar and consequently the mosaic tesserae detachment has been highlighted during the restoration plan. The biofilm microbial consortium has been investigated by an integrate approach based on Microscopy analysis (O.M., C.L.S.M.), in vitro culture (Nutrien and Saboraud media) and molecular biology investigation (DNA target sequence amplification, sequencing, sequence analysis). A microbial diversity has been revealed belonging to bacteria (Bacillus) and fungi (Alternaria, Aspergillus), besides cyanobacteria (Chroococcus) and green algae (Chlorella). In order to control the biofilm colonization two essential oils (EO), Thymus vulgaris and Origanum vulgare, have been utilized and their antimicrobial activity, preliminarily in vitro (agar disc diffusion methods) and after ex situ and in situ evaluated. This experimentation is aimed at identifying and implementing green biocides for the control of microbial colonization, a promising technology with a reduced impact on human health and environment, able to replace traditional biocide action.

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The Anti-Proliferative Effects of Enterolactone in Prostate Cancer Cells: Evidence for the Role of DNA Licencing Genes, mi-R106b Cluster Expression, and PTEN Dosage

Cited by 25 publications

References 46 publications

Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta‐analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls

Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta‐analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls

Resveratrol and pterostilbene as a microRNA‐mediated chemopreventive and therapeutic strategy in prostate cancer

Solunto archaeological park in Sicily: life under mosaic tesserae

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