The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans

Cuong, Vu Thi; Chen, Weidong; Shi, Jiahao; Zhang, Mengjie; Yang, Hua; Wang, Ning; Yang, Shaoming; Li, Jianfeng; Yang, Ping; Fei, Jian

doi:10.1016/j.exger.2018.11.016

Cited by 39 publications

(25 citation statements)

References 22 publications

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“…Vascular aging is commonly accompanied with low-grade inflammation and degenerative structural changes and stiffness of blood vessels and is considered a risk factor for the development of CVDs, such as CHD and hypertension (Franceschi et al, 2000;Lakatta and Levy, 2003). In the mesenteric arterioles of old rats, GBE had a protective effect that alleviated arterial stiffness and improved endothelial health (Cuong et al, 2019). In these aged mesenteric arterioles, GBE improved vascular elasticity by narrowing the EC gap, increasing curvature of inner elastic membrane and reducing the middle collagen fiber layer.…”

Section: In Vivo Preclinical Evaluation Of Ginkgo Bilobamentioning

confidence: 99%

“…In these aged mesenteric arterioles, GBE improved vascular elasticity by narrowing the EC gap, increasing curvature of inner elastic membrane and reducing the middle collagen fiber layer. These changes were accompanied by decreased phosphorylation levels of Akt/FoxO3a signaling components, which usually contributes to vascular dysfunction (Cuong et al, 2019).…”

Section: In Vivo Preclinical Evaluation Of Ginkgo Bilobamentioning

confidence: 99%

“…As stated earlier, antioxidants are very important when it comes to the prevention of atherosclerosis. G. lucidum can act as an antioxidant; in the model organism Caenorhabditis elegans, G. lucidum protected C. elegans against paraquat and heavy metalinduced oxidative stress via the diet restriction pathway and the mTOR/S6K signaling pathway, respectively (Cuong et al, 2019). G. lucidum has been found to protect human lymphocyte DNA from hydrogen peroxide-induced oxidative damage (Shi et al, 2002).…”

Section: G Lucidum At the Bench: Mechanism Of Action In Cvdsmentioning

confidence: 99%

“…Bioactive/active fractions: By decreasing the levels of creatine phosphokinase (Hikino et al, 1985;Tomoda et al, 1986;Shi et al, 2002;Shi et al, 2010;Lasukova et al, 2015;Wang et al, 2015;Wihastuti and Heriansyah, 2017;Cuong et al, 2019;Wu et al, 2019)…”

Section: Ganoderma Lucidummentioning

confidence: 99%

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Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an alternative treatment approach for several diseases including CVDs. Currently, there is an unprecedented drive for the use of herbal preparations in modern medicinal systems. This drive is powered by several aspects, prime among which are their cost-effective therapeutic promise compared to standard modern therapies and the general belief that they are safe. Nonetheless, the claimed safety of herbal preparations yet remains to be properly tested. Consequently, public awareness should be raised regarding medicinal herbs safety, toxicity, potentially lifethreatening adverse effects, and possible herb-drug interactions. Over the years, laboratory data have shown that medicinal herbs may have therapeutic value in CVDs as they can interfere with several CVD risk factors. Accordingly, there have been many attempts to move studies on medicinal herbs from the bench to the bedside, in order to effectively employ herbs in CVD treatments. In this review, we introduce CVDs and their risk factors. Then we overview the use of herbs for disease treatment in general and CVDs in particular. Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely Ginseng, Ginkgo biloba, Ganoderma lucidum, and Gynostemma pentaphyllum, are gathered and reviewed. In particular, the employment of these four plants in the context of CVDs, such as myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease, cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and critically discussed. We also endeavor to document the recent studies aimed to dissect the cellular and molecular cardio-protective mechanisms of the four plants, using recently reported in vitro and in vivo studies. Finally, we reviewed and reported the results of the

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Section: In Vivo Preclinical Evaluation Of Ginkgo Bilobamentioning

confidence: 99%

Section: In Vivo Preclinical Evaluation Of Ginkgo Bilobamentioning

confidence: 99%

Section: G Lucidum At the Bench: Mechanism Of Action In Cvdsmentioning

confidence: 99%

Section: Ganoderma Lucidummentioning

confidence: 99%

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Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

et al. 2020

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“… 142 In another study, G. lucidum protects Caenorhabditis elegans from paraquat- and heavy metals-induced oxidative stress through the mTOR signaling pathway. 143 In addition, Ganoderma lucidum can upregulate the Toll-interleukin 1 receptor intracellular domain and activate the MAPK pathway, which increases expression of DAF-16 – a transcription factor related to the lifespan of C. elegans , thereby extending its lifespan. 59 …”

Section: Therapeutic Drugs Targeting Senescencementioning

confidence: 99%

Advancements in therapeutic drugs targeting of senescence

Zhu

Meng

Ling

et al. 2020

Therapeutic Advances in Chronic Disease

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Aging leads to a high burden on society, both medically and economically. Cellular senescence plays an essential role in the initiation of aging and age-related diseases. Recent studies have highlighted the therapeutic value of senescent cell deletion in natural aging and many age-related disorders. However, the therapeutic strategies for manipulating cellular senescence are still at an early stage of development. Among these strategies, therapeutic drugs that target cellular senescence are arguably the most highly anticipated. Many recent studies have demonstrated that a variety of drugs exhibit healthy aging effects. In this review, we summarize different types of drugs promoting healthy aging – such as senolytics, senescence-associated secretory phenotype (SASP) inhibitors, and nutrient signaling regulators – and provide an update on their potential therapeutic merits. Taken together, our review synthesizes recent advancements in the therapeutic potentialities of drugs promoting healthy aging with regard to their clinical implications.

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Of Mice, Whales, Jellyfish and Men: In Pursuit of Increased Longevity

Guest

2019

Reviews on Biomarker Studies in Aging and Anti-Aging Research

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The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans

Cited by 39 publications

References 22 publications

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety

Advancements in therapeutic drugs targeting of senescence

Of Mice, Whales, Jellyfish and Men: In Pursuit of Increased Longevity

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