2019
DOI: 10.1016/j.ijbiomac.2019.08.149
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The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice

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Cited by 50 publications
(33 citation statements)
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“…SIRT1, the founding member of the sirtuin family, is regarded as a major modulator of DCM, because of its antioxidative and antiapoptotic effects [46]. Combined with previous evidence, the results in our study indicate that GDF11 and SIRT1 could dramatically inhibit oxidative damage by targeting the same antioxidative molecules, thereby reducing myocardial ROS [16,17,47]. Moreover, quercetin treatment simultaneously upregulates GDF11 and SIRT1 expression in broblasts [25].…”
Section: Discussionsupporting
confidence: 77%
“…SIRT1, the founding member of the sirtuin family, is regarded as a major modulator of DCM, because of its antioxidative and antiapoptotic effects [46]. Combined with previous evidence, the results in our study indicate that GDF11 and SIRT1 could dramatically inhibit oxidative damage by targeting the same antioxidative molecules, thereby reducing myocardial ROS [16,17,47]. Moreover, quercetin treatment simultaneously upregulates GDF11 and SIRT1 expression in broblasts [25].…”
Section: Discussionsupporting
confidence: 77%
“…In the ischemia-reperfusion AKI model, SIRT1 targets the deoxyacetylation of p53, FoxO1, and NF-κB to regulate the stress response, inflammation, cell senescence, and apoptosis (Grabowska et al, 2017;Zhang et al, 2017;Abdolvahabi et al, 2019;Wang et al, 2019). In addition, SIRT1mediated inhibition of tubular cell apoptosis has been shown to be the primary mechanism of renal protection (Liao et al, 2019;Ryu et al, 2019;Zhang et al, 2019). Our data also suggest that such a mechanism is important during cisplatin-induced AKI.…”
Section: Discussionsupporting
confidence: 52%
“…Therefore, this model was frequently used to investigate the influence of pharmacological and risk factors on the function and structure in the pancreas and intestine. Polysaccharide, as a main component of okra, exhibits protective effects on the kidneys in vivo and regulation of intestinal microbial disorders and other effects 26,38 . However, few studies have reported the effects of okra polysaccharides on acute pancreatitis.…”
Section: Discussionmentioning
confidence: 99%