The Anti-Leukemic Activity of Natural Compounds

Cotoraci, Coralia; Ciceu, Alina; Sasu, Alciona; Miuţescu, Eftimie

doi:10.3390/molecules26092709

Cited by 15 publications

(19 citation statements)

References 149 publications

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“…with these compounds (obtained by preparative chromatography) on HL-60 and P338 cell lines indicated a value of IC 50 for HL-60 and P338 greater than 100 μM [ 50 ]. Regarding the mechanism of action, other studies indicate that under the action of flavonoids (i.e., kaempferol) the activation of p53 is stimulated, and the level of proapoptotic proteins such as Bax and Bcl-2 is upregulated, favoring the beginning of apoptosis processes in leukemic cells [ 51 , 52 ]. The biological activity of PI products is due probably to iridoid glycosides such as aucubin, catalpol, or its derivatives, for which antimicrobial activities were reported against bacteria and fungi [ 20 , 40 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Studies Regarding the Pharmaceutical Potential of Derivative Products from Plantain

Zaharie

Radu

Pîrvu

et al. 2022

Plants

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In this study, three types of extracts isolated from leaves of Plantain (Plantago lanceolata) were tested for their chemical content and biological activities. The three bioproducts are combinations of polysaccharides and polyphenols (flavonoids and iridoidic compounds), and they were tested for antioxidant, antifungal, antitumor, and prebiotic activity (particularly for polysaccharides fraction). Briefly, the iridoid-enriched fraction has revealed a pro-oxidant activity, while the flavonoid-enriched fraction had a high antioxidant potency; the polysaccharide fraction also indicated a pro-oxidant activity, explained by the co-presence of iridoid glycosides. All three bioproducts demonstrated moderate antifungal effects against Aspergillus sp., Penicillium sp., and dermatophytes, too. Studies in vitro proved inhibitory activity of the three fractions on the leukemic tumor cell line THP-1, the main mechanism being apoptosis stimulation, while the polysaccharide fraction indicated a clear prebiotic activity, in the concentration range between 1 and 1000 µg/mL, evaluated as higher than that of the reference products used, inulin and dextrose, respectively.

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Section: Discussionmentioning

confidence: 99%

Studies Regarding the Pharmaceutical Potential of Derivative Products from Plantain

Zaharie

Radu

Pîrvu

et al. 2022

Plants

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“…The anti-proliferative and cytotoxic effect of EGCG has been investigated in different cancer cell lines, animal models, as well as clinical trials [20]. It has been stated that this compound inhibits proliferation and induces DNA fragmentation in different human leukemic cell lines in a dose-dependent manner [21].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Epigallocatechin gallate on Cross-talk Between Autophagy and Apoptosis in NALM-6 Cell Line

Gharehchahi

Zare

Dehbidi

et al. 2021

Preprint

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Background: Acute lymphoblastic leukemia is a prevalent hematological malignancy in 2-5-year-old children. Chemotherapy, as the most common treatment for ALL, is not usually responsive. Epigallocatechin gallate (EGCG), a small molecule extracted from green tea, has significant effects on tumor cells through different mechanisms, such as DNA damage, cell cycle arrest, oxidative stress, apoptosis, and autophagy. In this study, we investigated the impact of EGCG on autophagy and apoptosis in NALM-6 cell line. Methods and results: Cell viability and apoptosis were assessed by MTT and Trypan blue exclusion assay, and flow cytometry. It was shown that EGCG remarkably inhibited proliferation, reduced cell viability, and induced apoptosis in NALM-6 cell line (P<0.05). In addition, real-time PCR and western blot analysis were used to examine autophagy. It was observed that EGCG resulted in a 4-fold increase in LC3 protein level (P<0.05) while reducing the mRNA expression level of LC3B, P62/SQSTM1, and Atg2B genes (P<0.01). It also caused around 1.3-fold increase in DRAM1 mRNA expression level (P<0.05). Finally, it was indicated that the inhibition of autophagy affects apoptosis neither in untreated nor treated cells with EGCG.Conclusion: These results show that EGCG can induce apoptosis and autophagy in NALM-6 cell line while inhibition of autophagy cannot affect apoptosis in this cell line.

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“…Except for vitamins, there are lots of natural products that are proven to be related to AML and have the potential to contribute to the idea against the multi-drug resistance of AML cells. Those natural products have different anti-tumor effects, including increasing apoptosis of AML cells, inducing cell cycle arrest, anti-proliferative effects, and even reverse of drug resistance [ 142 , 143 , 144 ]. There are a few studies involved in mice in this field, including (-)-Epicatechin [ 145 ], quercetin [ 146 ], green tea [ 147 ], curcumin [ 148 ], parthenolide [ 149 ], emodin [ 150 ], compound kushen injection [ 151 ], and northern labrador tea extracts [ 152 ].…”

Section: Application Of Natural Products In Aml Therapymentioning

confidence: 99%

“…On the other hand, qinghuang powder containing arsenic, used as an alternative treatment for elderly AML patients, showed no significant difference in overall survival [ 154 ]. In conclusion, the research is limited and there is a lack of clinical effectiveness proven to happen in the human population [ 142 , 143 ].…”

Section: Application Of Natural Products In Aml Therapymentioning

confidence: 99%

Targeting the Tumor Microenvironment in Acute Myeloid Leukemia: The Future of Immunotherapy and Natural Products

et al. 2022

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The tumor microenvironment (TME) plays an essential role in the development, proliferation, and survival of leukemic blasts in acute myeloid leukemia (AML). Within the bone marrow and peripheral blood, various phenotypically and functionally altered cells in the TME provide critical signals to suppress the anti-tumor immune response, allowing tumor cells to evade elimination. Thus, unraveling the complex interplay between AML and its microenvironment may have important clinical implications and are essential to directing the development of novel targeted therapies. This review summarizes recent advancements in our understanding of the AML TME and its ramifications on current immunotherapeutic strategies. We further review the role of natural products in modulating the TME to enhance response to immunotherapy.

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The Anti-Leukemic Activity of Natural Compounds

Cited by 15 publications

References 149 publications

Studies Regarding the Pharmaceutical Potential of Derivative Products from Plantain

Studies Regarding the Pharmaceutical Potential of Derivative Products from Plantain

The Effect of Epigallocatechin gallate on Cross-talk Between Autophagy and Apoptosis in NALM-6 Cell Line

Targeting the Tumor Microenvironment in Acute Myeloid Leukemia: The Future of Immunotherapy and Natural Products

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