The anti-inflammatory properties of vinpocetine mediates its therapeutic potential in management of atherosclerosis
Abdullah A. Alshehri,
Hayder M. Al-kuraishy,
Ali I. Al-Gareeb
et al.
Abstract:Atherosclerosis (AS) formation is enhanced by different mechanisms including cytokine generation, vascular smooth muscle cell proliferation, and migration. One of the recent treatments towards endothelial dysfunction and AS is Vinpocetine (VPN). VPN is a potent inhibitor of phosphodiesterase enzyme 1 (PDE-1) and has anti-inflammatory and antioxidant effects through inhibition the expression of nuclear factor kappa B (NF-κB). VPN has been shown to be effective against the development and progression of AS. Howe… Show more
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