The anti-inflammatory potential of phenolic compounds in grape juice concentrate (G8000™) on 2,4,6-trinitrobenzene sulphonic acid-induced colitis

Paiotti, Ana Paula Ribeiro; Neto, Ricardo Artigiani; Marchi, Patrícia Gelli Feres de; Silva, Roseane Mendes; Pazine, Vanessa Lima; Noguti, Juliana; Pastrelo, Maurício Mercaldi; Gollücke, Andréa Pittelli Boiago; Miszputen, Sender Jankiel; Ribeiro, Daniel Araki

doi:10.1017/s000711451300007x

Cited by 34 publications

(30 citation statements)

References 39 publications

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“…The GELNs‐mediated interspecies information transfer is proved to be functional, protecting mice against DSS‐induced colitis. The protective effect on TNBS‐induced colitis has also been observed in grape juice containing GELNs in another research . In vitro study showed that the uptake of GELNs promoted Lgr5+ intestinal stem cell proliferation as well as subsequent intestinal organoid formation, which indicated that the amelioration of mouse intestinal inflammation may be at least partly because of the enhancement of epithelial reconstitution.…”

Section: Therapeutic Potential Of Exosome In Inflammatory Bowel Diseasesupporting

confidence: 53%

Exosome in intestinal mucosal immunity

Lü

Ran

et al. 2016

J of Gastro and Hepatol

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Intercellular communication of immune cells is critical to elicit efficient inflammatory responses. In intestinal mucosa, imbalance in pro-inflammatory and anti-inflammatory mediators, especially cytokines and chemokines, characterizes the underlying immune mechanisms of inflammatory bowel disease. Exosomes, small membrane vesicles secreted into the extracellular environment, are emerging as another important intercellular messenger in immune responses. A major recent breakthrough in this field unveils the capacity of exosomes to mediate the functional transfer of genetic materials (mRNAs and miRNAs) between immune cells. RAB27A and RAB27B are two small GTPases involved in exosome secretion. With respect to intestinal mucosal immunity, increased number of RAB27A-positive immune cells and RAB27B-positive immune cells are demonstrated in the colonic mucosa of patients with active ulcerative colitis as compared with that of healthy controls. This indicates the important role of exosome-mediated immune responses in the pathogenesis of inflammatory bowel disease. Here, we will discuss the immune properties of exosomes and recent advances in their function with a special focus on intestinal mucosal immunity.

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Section: Therapeutic Potential Of Exosome In Inflammatory Bowel Diseasesupporting

confidence: 53%

Exosome in intestinal mucosal immunity

Lü

Ran

et al. 2016

J of Gastro and Hepatol

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“…However, HF-feeding did not increase mRNA markers of inflammation in the ileum or proximal colon or IAP activity in duodenal mucosa after 16 weeks. In contrast, other research has shown that feeding non-physiological levels of saturated fat triggers intestinal inflammation that contribute to increase systemic inflammation and insulin resistance, possibly due to intestinal dysbiosis and barrier dysfunction [7–13, 18, 19, 68–70]. …”

Section: Discussionmentioning

confidence: 99%

A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice

Collins

Hoffman

Martinez

et al. 2016

The Journal of Nutritional Biochemistry

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The objective of this study was to determine if consuming an extractable or non-extractable fraction of table grapes reduced the metabolic consequences of consuming a high-fat, American-type diet. Male C57BL/6J mice were fed a low fat (LF) diet, a high fat (HF) diet, or a HF diet containing whole table grape powder (5% w/w), an extractable, polyphenol-rich (HF-EP) fraction, a non-extractable, polyphenol-poor (HF-NEP) fraction, or equal combinations of both fractions (HF-EP+NEP) from grape powder for 16 weeks. Mice fed the HF-EP and HF-EP+NEP diets had lower percentages of body fat and amounts of white adipose tissue (WAT) and improved glucose tolerance compared to the HF-fed controls. Mice fed the HF-EP+NEP diet had lower liver weights and triglyceride (TG) levels compared to the HF-fed controls. Mice fed the HF-EP+NEP diets had higher hepatic mRNA levels of hormone sensitive lipase and adipose TG lipase, and decreased expression of c-reactive protein compared to the HF-fed controls. In epididymal (visceral) WAT, the expression levels of several inflammatory genes were lower in mice fed the HF-EP and HF-EP+NEP diets compared to the HF-fed controls. Mice fed the HF diets had increased myeloperoxidase activity and impaired localization of the tight junction protein zonula occludens-1 in ileal mucosa compared to the HF-EP and HF-NEP diets. Several of these treatment effects were associated with alterations in gut bacterial community structure. Collectively, these data demonstrate that the polyphenol-rich, EP fraction from table grapes attenuated many of the adverse health consequences associated with consuming a HF diet.

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“…CTRL and Cd groups were treated with drinking water by gavage during the same experimental period. The grape juice group was not included into this experimental design because our research group has evaluated the protective potential of grape juice under different paradigms and the results have revealed that animals treated with grape juice only did not change such biological parameters investigated (Pires et al 2013;Paiotti et al 2013;de Jesus et al 2014).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Antimutagenic and antigenotoxic potential of grape juice concentrate in blood and liver of rats exposed to cadmium

Moura

Ribeiro

Jesus

et al. 2014

Environ Sci Pollut Res

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The aim of this study was to evaluate the antimutagenic and antigenotoxic potential of grape juice concentrate in rodent organs exposed to cadmium chloride intoxication. A total of 15 Wistar rats were distributed into three groups (n = 5), as follows: control group (CTRL; nontreated group), cadmium group (Cd), and cadmium-grape juice group (Cd + GJ). Exposed animals received intraperitoneal injection of cadmium chloride (1.2 mg/kg body weight) diluted in water and, after 15 days, Cd + GJ group received grape juice concentrate for 15 days, by gavage (0.8 mL, 1.18 mg of polyphenols kg(-1) day(-1)). Grape juice concentrate was able to decrease genotoxic effects induced by cadmium in peripheral blood and liver cells as depicted by single cell gel (comet) and micronucleus assays. A decrease for anti-8-hydroxy-20-deoxyguanosine (8OHdG) expression in hepatocytes of animals exposed to cadmium and treated with grape juice concentrate was also detected. Higher CuZn-SOD activity was observed in liver cells of the Cd + GJ group. No remarkable differences were seen regarding Mn-SOD activity among groups. Taken together, our results demonstrate that grape juice concentrate was able to exert antimutagenic and antigenotoxic activities in blood and liver cells of rats exposed to cadmium.

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The anti-inflammatory potential of phenolic compounds in grape juice concentrate (G8000™) on 2,4,6-trinitrobenzene sulphonic acid-induced colitis

Cited by 34 publications

References 39 publications

Exosome in intestinal mucosal immunity

Exosome in intestinal mucosal immunity

A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice

Antimutagenic and antigenotoxic potential of grape juice concentrate in blood and liver of rats exposed to cadmium

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