The anti‐inflammatory mechanism of 635 nm light‐emitting‐diode irradiation compared with existing COX inhibitors

Abstract

Taken together, 635 nm irradiation, unlike indomethacin and ibuprofen, can directly dissociate the ROS. This inhibits cPLA(2), sPLA(2), and COX expression, and results in the inhibition of PGE(2) release. Thus, we suggest that 635 nm irradiation inhibits PGE(2) synthesis like COX inhibitor and appears to be useful as an anti-inflammatory tool.

Correlation between light transmission and permeability of human dentin

“…LED phototherapy has been shown to produce positive biological effects, such as an increase of cell proliferation and collagen synthesis [14], as well as expression of growth factors and different extracellular matrix components [2,3]. Fig.…”

“…Phototherapy using light emitting diodes (LEDs) has been used in several health fields, including the treatment of dermatitis, Alzheimer's disease, and muscle analgesia [1][2][3]. Light has also been applied combined with a photosensitizing agent in the photodynamic therapy for the treatment of neoplasias [4].…”

“…Other positive effects of phototherapy have been reported, including acceleration of the wound healing process [10][11][12], enamel remineralization [13], cell proliferation and collagen synthesis [14], increase of cell metabolism [15], expression of growth factors and extracellular matrix components, as well as stimulation of ATP synthesis and reactive oxygen species (ROS) production [2,3].…”

Anti-inflammatory activities of light emitting diode irradiation on collagen-induced arthritis in mice (a secondary publication)

“…In an in vitro experimental setting, prostaglandin (PG) E2, cyclooxygenase (COX) and lipoprotein-associated phospholipase (PLA)2 gene expression of human gingival fibroblast culture which usually increases when stimulated with arachidonic acid, was suppressed by treatment with 635 LED irradiation. 13) . In our present study, in order to compare and contrast the anti-inflammatory activity of LEDs with that of NIR and FEL, the treatment parameters of irradiation time (500 s) and total energy density (5 J/cm 2 ) were maintained.…”

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

“…Il a été démontré que le laser diode de faible puissance à GaAs (904 nm) réduit de manière significative la migration cellulaire des polynucléaires neutrophiles dans un modèle expérimental de péritonite induit par les lipopolysaccharides bactériens [23]. Dans l'étude de Lim et al (2007) [24], l'irradiation par le laser 635 nm a permis de mettre en évidence une inhibition du relarguage des prostaglandines inflammatoires (PGE2) et des deux isoformes (1 et 2) de la cyclooxygénase [25]. Il a été démontré que les lasers de faible puissance avaient par ailleurs une action antalgique en augmentant la synthèse et le relarguage des endorphines, ainsi qu'en diminuant le relarguage de récepteurs nociceptifs comme la bradykinine et la sérotonine [26][27][28][29].…”