The anti-inflammatory effects of phenolic dental medicaments as determined by mouse ear edema assay.

Dohi, Toshihiro; Terada, Hiroshi; Anamura, Shinichi; Okamoto, Hiroshi; Tsujimoto, Akira

doi:10.1254/jjp.49.535

Cited by 16 publications

(13 citation statements)

References 15 publications

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“…Most of the betel leaf extract got from various chemical substances such as ethanol, methanol and ethyl acetate which possess antimutagenic, anti carcinogenic, antiplaque, antidiabetic, anti-inflammatory and antibacterial activities [11][12][13][14][15][16] . Eugenol is one of the main chemical constituent of betel leaf and has been exposed to have anti-inflammatory properties in a number of animal studies 17 . Besides the eugenol, the betel leaves have other major constituents, hydroxychavicol, alphatocopherol, and allylpyro catechol have also play important role to enhance the levels of growth stimulating hormone (GSH) in mouse skin and liver 18,19 .…”

Section: Issn: 2250-1177mentioning

confidence: 99%

Antioxidant Activity (Phenol and Flavonoid Content ) of Three Different Cultivars of Piper Betle L. (Piperaceae)

Harini¹,

Sougandhi

Tenkayala

et al. 2018

J. Drug Delivery Ther.

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In the present study, an attempt has been made for the estimation of total phenol and flavonoid content and their radical scavenging properties using Piper betle (L.) leaves. In that, Cultivars i.e., Nov Bangla (NB), Sirugamani-1 (SGM-1) and Halisar Sanchi (HS) were selected for this study. The total phenolic content was ranged from 95.04 to 127.33 mg/100g equivalent to gallic acid and flavonoids were ranged from 51.72 to 61.08 mg/ 100g equivalent to standards of Catechin. In vitro antioxidant activity was estimated using 1,1-diphenyl-2-picryl hydrazyl (DPPH), free radical scavenging activity, improved ABTS radical cation decolorization assay and ferric reducing antioxidant power (FRAP) assay. Among all the cultivars, The highest Phenol content (93.79%) was observed for Sirugamani-1 by DPPH method and highest Phenol content (96.12% & 6791.86 (µg/g) was obtained for Halisar Sanchi by ABTS assay and FRAP activity respectively. The study revealed that the leaves of Piper betle (L.) has higher amount of antioxidant activity and it could be used for any novel drug preparation.

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Section: Issn: 2250-1177mentioning

confidence: 99%

Antioxidant Activity (Phenol and Flavonoid Content ) of Three Different Cultivars of Piper Betle L. (Piperaceae)

Harini¹,

Sougandhi

Tenkayala

et al. 2018

J. Drug Delivery Ther.

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“…Previous studies have been carried out on the anti-inflammatory activity of eugenol with different methods and mechanisms, and showed a significant activity. These include croton oil which induced edema (Dohi et al, 1989), tooth pulp microsomes and homogenates, leukocyte, kidney medulla (Anamura, 1989), IL-1b-stimulated gingival fibroblast (Koh et al, 2013), and carrageenan-induced paw edema (Saeed et al, 1995). Generally, inflammation involves the formation of both prostaglandins and leukotrienes as mediators followed by the liberation of neutrophils and the production of reactive oxygen species (ROS).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Chemical composition and biological activities of essential oil ofBeilschmiedia pulverulenta

Salleh

Ahmad

Khong

et al. 2015

Pharmaceutical Biology

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Context: The ethnopharmacological study of Beilschmiedia indicates that several species are used for the treatment of various ailments. Objective: This is the first study of the chemical composition of Beilschmiedia pulverulenta Kosterm (Lauraceae) essential oil and its antioxidant, antimicrobial, antityrosinase, antiinflammatory, and anticholinesterase activities. Materials and methods: The antioxidant activities were evaluated by b-carotene, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric-reducing antioxidant power (FRAP), and phenolic content at different concentrations. The antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi were revealed by disk diffusion and microdilution. The antityrosinase and anti-inflammatory activities were assayed against mushroom tyrosinase and lipoxygenase enzymes. The anticholinesterase activity was analyzed using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Results: Forty-two components were detected in B. pulverulenta oil with eugenol (45.3%) being the major component. The oil phenolic content and the FRAP were 660.1 mg gallic acid/g and 604.0 mg ascorbic acid/g, respectively. The oil gave an IC 50 value of 94.5 mg/mL and an inhibition of 93.9% in DPPH and b-carotene, respectively. The antimicrobial activity showed that the oil had strong activity against all Gram-positive bacteria with an minimum inhibitory concentration (MIC) value each of 62.5 mg/mL and moderate against all fungi with MIC and minimum bactericidal concentration (MBC) values each of 125 mg/mL. The oil showed significant antityrosinase and anti-inflammatory activities with 67.6 and 62.5% inhibition, respectively. In addition, the oil had moderate AChE (56.5%) and BChE (48.2%) activities. Discussion and conclusion: The results show that the oil could potentially be used for nutraceutical industries, food manufactures, and therapeutic agents against various diseases such as inflammation and rheumatism.

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“…For background regarding the medicinal properties of eugenol, see: Feng & Lipton (1987); Dohi et al (1989). For the synthesis of the aspirin eugenol ester and its biological activity, see: Li et al (2011).…”

Section: Related Literaturementioning

confidence: 99%

4-Allyl-2-methoxyphenyl 2-acetoxybenzoate

Liu

Yang

et al. 2011

Acta Cryst E

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Key indicators: single-crystal X-ray study; T = 296 K; mean (C-C) = 0.005 Å; R factor = 0.051; wR factor = 0.142; data-to-parameter ratio = 14.0.In the title compound, C 19 H 18 O 5 , the ester group is twisted with respect to the acetylsalicylic acid and eugenol rings at dihedral angles of 22.48 (2) and 81.07 (1) , respectively. The dihedral angle between the two benzene rings is 60.72 (1) . The crystal packing exhibits no significantly short intermolecular contacts. Related literature

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The anti-inflammatory effects of phenolic dental medicaments as determined by mouse ear edema assay.

Cited by 16 publications

References 15 publications

Antioxidant Activity (Phenol and Flavonoid Content ) of Three Different Cultivars of Piper Betle L. (Piperaceae)

Antioxidant Activity (Phenol and Flavonoid Content ) of Three Different Cultivars of Piper Betle L. (Piperaceae)

Chemical composition and biological activities of essential oil ofBeilschmiedia pulverulenta

4-Allyl-2-methoxyphenyl 2-acetoxybenzoate

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