The Anti Inflammatory Effects of High Density Lipoproteins

Murphy, Andrew; Chin-Dusting, Jaye; Sviridov, Dmitri; Woollard, Kevin J.

doi:10.2174/092986709787458425

Cited by 107 publications

(91 citation statements)

References 115 publications

(151 reference statements)

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“…The cardioprotective properties of high-density lipoprotein (HDL) are well established (Murphy et al, 2009b), with plasma levels negatively correlating with cardiovascular events (Gordon et al, 1977). The ability of HDL to modulate a number of different cellular processes ranging from regulating hematopoiesis (Murphy et al, 2011a) to inhibiting activation of circulating cells (Murphy et al, , 2011b to having a major role in the reverse cholesterol transport system has made HDL an attractive potential therapy for cardiovascular disease .…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Functions of Apolipoprotein A-I and High-Density Lipoprotein Are Preserved in Trimeric Apolipoprotein A-I

Murphy¹,

Hoang²,

Aprico³

et al. 2012

J Pharmacol Exp Ther

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Raising high-density lipoprotein (HDL) levels is proposed as an attractive target to treat cardiovascular disease. However, a number of clinical studies examining the effect of HDL-raising therapies have been prematurely halted due to futility. Therefore there is a need for alternative therapies. Infusion of reconstituted HDL (rHDL) particles is still considered as a viable approach to increasing HDL levels. In this study we have profiled the antiinflammatory effects of a trimeric-HDL particle. We show that trimeric apoA-I and rHDL particles promote cholesterol efflux to a similar rate as native apoA-I particles in both ABCA1-dependent and -independent pathways. Trimeric particles inhibited ICAM-1 and VCAM-1 expression and the ability of the endothelium to capture monocytes under shear flow. Monocyte activation, CD11b-dependent adhesion, and monocyte recruitment under shear flow conditions were perturbed by the trimeric particles. Our data suggest that trimeric rHDL particles can be constructed without any loss of function, preserving the anti-inflammatory effects of HDL that are key to its in vivo actions.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Functions of Apolipoprotein A-I and High-Density Lipoprotein Are Preserved in Trimeric Apolipoprotein A-I

Murphy¹,

Hoang²,

Aprico³

et al. 2012

J Pharmacol Exp Ther

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“…ApoA-Icontaining HDL particles are antiatherogenic and protect against atherogenesis via reverse cholesterol transport and play an important role in antiinflammatory and antithrombotic response. 1 Therefore, therapeutic HDL elevation may open new avenues for the treatment of atherosclerosis. 1 Scavenger receptor class B type I (SR-BI) is the receptor for HDL, mediating the transport of cholesterol and cholesteryl esters from HDL particles.…”

mentioning

confidence: 99%

“…1 Therefore, therapeutic HDL elevation may open new avenues for the treatment of atherosclerosis. 1 Scavenger receptor class B type I (SR-BI) is the receptor for HDL, mediating the transport of cholesterol and cholesteryl esters from HDL particles. It is primarily expressed in liver and nonplacental steroidogenic tissues and involved in selective uptake of cholesteryl esters from HDL.…”

mentioning

confidence: 99%

The Molecular Mechanisms of HDL and Associated Vesicular Trafficking Mechanisms to Mediate Cellular Lipid Homeostasis

Schmitz

Grandl

2009

ATVB

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Abstract-HDL functions mainly as a cholesterol scavenger, facilitating transport of cholesterol to the liver for conversion to bile acids and secretion into the bile for elimination or recycling in the enterohepatic bile acid cycle.Because of its major function in cholesterol clearance, HDL is in general considered to be atheroprotective. From cell cholesterol can be removed by efflux especially to apoA-I and HDL as extracellular acceptors which transport the cholesterol to the liver for excretion. This process is called reverse cholesterol transport. In this context the ATP binding cassette transporter protein ABCA1 facilitates cellular cholesterol and phospholipid release to apoA-I-containing HDL precursors. In addition ABCA1 plays a role in vesicular lipid transport mechanisms required for HDL particle formation. In general to maintain intracellular lipid homeostasis, sterols and associated lipids move between cellular compartments by vesicular and nonvesicular pathways. However, cholesterol sorting on vesicle formation is poorly understood. This review summarizes the current knowledge of the molecular mechanisms of HDL and associated vesicular trafficking mechanisms to mediate cellular lipid homeostasis.

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“…HDL-C molecules counteract macrophage migration and remove cholesterol from those cells. HDL-C exerts antiinfl ammatory, anti-oxidant and anti-thrombotic effects (17,19,20) . Classically known as the anti-atherogenic lipoprotein, HDL promotes reverse cholesterol transport from the arterial wall, specifi cally from lipid-laden macrophages (19,20) .…”

Section: Discussionmentioning

confidence: 99%

Association of Monocyte-to-HDL Cholesterol Ratio with Cardiac Syndrome X is Linked to Systemic Inflammation

Alizade¹,

Avcı²,

Güner³

et al. 2016

Kosuyolu Heart Journal

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Introduction: The aim of this study was to investigate an easily available infl ammatory marker and monocyteto-high-density lipoprotein cholesterol ratio (MHR) in patients with cardiac syndrome X (CSX). Patients and Methods:The study population included 100 patients of which 50 had CSX (CSX group) and 50 had normal coronary angiograms (control group). Results:Total white blood cell (WBC) count, monocyte count, neutrophil count, NLR, high-sensitivity C-reactive protein (hs-CRP), C-reactive protein (CRP) and MHR were higher in the CSX group (p< 0.05), whereas high-density lipoprotein cholesterol (HDL-C) level was signifi cantly lower in the CSX group as compared with that in the control group (p< 0.05). In the correlation analysis, MHR revealed a signifi cantly positive correlation with hs-CRP (r= 0.375, p< 0.001) and CRP (r= 0.403, p< 0.001). In the multivariate logistic regression analysis, MHR was independently associated with the presence of CSX (odds ratio: 1.250, 95% confi dence interval [CI]: 1.240-1.461, p< 0.001). Using a cut-off level of 90.6, pre-procedural MHR predicted the presence of slow coronary fl ow (SCF) with a sensitivity of 78% and specifi city of 70%. Conclusion:In conclusion, our fi ndings revealed that higher MHR levels were signifi cantly and independently associated with the presence of CSX.

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The Anti Inflammatory Effects of High Density Lipoproteins

Cited by 107 publications

References 115 publications

Anti-Inflammatory Functions of Apolipoprotein A-I and High-Density Lipoprotein Are Preserved in Trimeric Apolipoprotein A-I

Anti-Inflammatory Functions of Apolipoprotein A-I and High-Density Lipoprotein Are Preserved in Trimeric Apolipoprotein A-I

The Molecular Mechanisms of HDL and Associated Vesicular Trafficking Mechanisms to Mediate Cellular Lipid Homeostasis

Association of Monocyte-to-HDL Cholesterol Ratio with Cardiac Syndrome X is Linked to Systemic Inflammation

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