The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus

Kadoglou, Nikolaos P.E.; Iliadis, Fotios; Angelopoulou, Nickoletta; Perrea, Despina; Ampatzidis, G.; Liapis, Christos D.; Alevizos, Miltiadis

doi:10.1097/hjr.0b013e3282efaf50

Cited by 256 publications

(193 citation statements)

References 45 publications

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“…We should take into consideration that physical exercise improves the metabolic profile and has anti-inflammatory effects in DM2 patients, even when no significant loss of body weight is achieved 14 .…”

Section: Figure 3 -Postprandial Glycemia Over the 20 Weeks Of Spep Inmentioning

confidence: 99%

Efeito da freqüência do exercício físico no controle glicêmico e composição corporal de diabéticos tipo 2

Vancea¹,

Vancea²,

Pires³

et al. 2009

Arq. Bras. Cardiol.

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Section: Figure 3 -Postprandial Glycemia Over the 20 Weeks Of Spep Inmentioning

confidence: 99%

Efeito da freqüência do exercício físico no controle glicêmico e composição corporal de diabéticos tipo 2

Vancea¹,

Vancea²,

Pires³

et al. 2009

Arq. Bras. Cardiol.

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“…The improvements in cardiorespiratory fitness with aerobic training may be a better predictor of changes in HbA 1c than improvements in strength. [2][3][4][5] and resistance training increases muscular strength [2,7,8] in adults with type 2 diabetes, while higher cardiorespiratory fitness [10,11] and muscular fitness [12] are associated with reduced overall mortality rates. The Diabetes Aerobic and Resistance Exercise (DARE) Trial (ClinicalTrials.gov registration no.…”

mentioning

confidence: 99%

Associations between physical fitness and HbA1c in type 2 diabetes mellitus

et al. 2010

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Aim/hypothesis In people with type 2 diabetes, exercise improves glucose control (as reflected in HbA 1c ) and physical fitness, but it is not clear to what extent these exercise-induced improvements are correlated with one another. We hypothesised that reductions in HbA 1c would be related: (1) to increases in aerobic fitness and strength respectively in patients performing aerobic training or resistance training; and (2) to changes in strength and aerobic fitness in patients performing aerobic and resistance training. Methods We randomly allocated 251 type 2 diabetes patients to aerobic, resistance, or aerobic plus resistance training, or to a sedentary control group. Peak oxygen consumption (V : O 2peak ), workload, treadmill time and ventilatory threshold measurements from maximal treadmill exercise testing were measured at baseline and 6 months.Muscular strength was measured as the maximum weight that could be lifted eight times on the leg press, bench press and seated row exercises. Results With aerobic training, significant associations were found between changes in both V : O 2peak (p=0.040) and workload (p=0.022), and changes in HbA 1c. With combined training, improvements in V : O 2peak (p = 0.008), workload (p=0.034) and ventilatory threshold (p=0.003) were significantly associated with changes in HbA 1c. Increases in strength on the seated row (p=0.006) and in mid-thigh muscle cross-sectional area (p=0.030) were significantly associated with changes in HbA 1c after resistance exercise, whereas the association between increases in muscle cross-sectional area and HbA 1c in participants doing aerobic plus resistance exercise (p= 0.059) was of borderline significance. Conclusions/interpretation There appears to be a link between changes in fitness and HbA 1c . The improvements in cardiorespiratory fitness with aerobic training may be a better predictor of changes in HbA 1c than improvements in strength.

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“…10 Furthermore, small studies of diabetic patients demonstrated reductions in C-reactive protein levels in the exercise intervention subgroup. 11,12 However, for type 2 diabetes, the association between C-reactive protein and development of cardiovascular disease is still under debate. Moreover, unknown is the extent to which the beneficial combined effects of exercise on metabolism, inflammation and vascular function can be expected to reduce the prevalence of atherosclerotic disease in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Regarding C-reactive protein, some studies on type 2 diabetes reported associations with exercise capacity 9,10 and a reduction in C-reactive protein levels after a program of physical training. 11,12 The aim of this study was to investigate the independent relationships between exercise capacity (evaluated by a self-reported questionnaire and, for a sub-sample of patients, by a standard treadmill test) and ambulatory BP monitoring data, aortic pulse wave velocity (PWV; which reflects arterial stiffness) and C-reactive protein, over and above other known conditions that negatively impact physical activity (such as the presence of chronic degenerative complications, obesity, arterial hypertension and left ventricular diastolic dysfunction).…”

Section: Introductionmentioning

confidence: 99%

High fitness is associated with a better cardiovascular risk profile in patients with type 2 diabetes mellitus

et al. 2011

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Novel cardiovascular risk markers, such as ambulatory blood pressure (BP) and aortic stiffness, have been proposed. The aim of this study was to investigate the relationship between physical fitness and some of these risk markers in 575 type 2 diabetic patients. In a cross-sectional design, clinical, laboratory, echocardiographic, aortic pulse wave velocity and 24-h ambulatory BP monitoring data were obtained. Fitness was self-reported using a standard questionnaire of daily activities, and then assessed as belonging to one of the three categories: low (o4 metabolic equivalents (METs)), moderate (X4 to o7 METs) and high fitness (X7 METs). In a random sub-sample of 265 patients, self-reported fitness was confirmed by a standard treadmill test. Statistical analysis was carried out, using tests including bivariate tests among the three categories and multivariate logistic regression. Agreement between self-reported and measured fitness was substantial (weighted j: 0.63). High fitness patients were younger, frequently male, had a decreased prevalence of degenerative complications, lower office and ambulatory BP levels, particularly during the night and had an increased prevalence of the normal nocturnal dipping pattern. High fitness patients also had lower hemoglobin A1c and C-reactive protein levels, a decreased prevalence of left ventricular hypertrophy and increased aortic stiffness. On multiple logistic regression, after adjustments for several confounders, high fitness was independently associated with a higher likelihood of having low C-reactive protein (odds ratio (OR): 2.3, 95% confidence interval (CI): 1.3-3.9), controlled nighttime BP (OR: 2.3, 95% CI: 1.4-3.8), normal dipping pattern (OR: 2.1, 95% CI: 1.2-3.5) and low aortic stiffness (OR: 2.5, 95% CI: 1.3-4.8). Patients with moderate fitness had intermediate OR. In conclusion, a moderate to high level of physical fitness was independently associated with several favorable intermediate cardiovascular risk markers, which may contribute to decreasing the burden of morbi-mortality in patients with type 2 diabetes. Hypertension Research (2011) 34, 856-861; doi:10.1038/hr.2011; published online 12 May 2011Keywords: ambulatory blood pressure; aortic stiffness; cardiorespiratory fitness; C-reactive protein; type 2 diabetes INTRODUCTION Studies in type 2 diabetic patients have found that high levels of aerobic fitness are associated with lower levels of overall mortality and mortality due to cardiovascular events, independent of traditional cardiovascular risk factors. 1,2 However, the relationship between cardiorespiratory fitness and some recently described non-traditional cardiovascular risk factors, such as ambulatory blood pressures (BPs), aortic stiffness and C-reactive protein, has not been as well characterized for type 2 diabetic patients. Whether these factors contribute independently to low fitness or merely reflect more advanced cardiovascular complications is unknown.Compared with office BPs, ambulatory BPs are stronger cardiovascular risk predictors...

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The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus

Abstract: Aerobic exercise training without significant weight loss improves metabolic profile and exerts anti-inflammatory effects in patients with type 2 DM.

Cited by 256 publications

References 45 publications

Efeito da freqüência do exercício físico no controle glicêmico e composição corporal de diabéticos tipo 2

Efeito da freqüência do exercício físico no controle glicêmico e composição corporal de diabéticos tipo 2

Associations between physical fitness and HbA1c in type 2 diabetes mellitus

High fitness is associated with a better cardiovascular risk profile in patients with type 2 diabetes mellitus

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