The anti-inflammatory effects of 15-HETE on osteoarthritis during treadmill exercise

You, Tian; Gou, Jian; Zhang, He; Lu, Jinghan; Jin, Zhuangzhuang; Jia, Shuangshuo; Bai, Lan

doi:10.1016/j.lfs.2021.119260

Cited by 16 publications

(12 citation statements)

References 36 publications

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“…Primary chondrocytes were obtained from the cartilage of male Sprague−Dawley rats (4 weeks old, specific pathogen-free), as previously described. 21 Briefly, cartilage pieces were trimmed to 1 mm 3 and digested with pronase K (4 mg/mL; Roche, Basel, Switzerland) for 2 h, followed by a cycle of collagenase (1.6 mg/ mL; Roche) digestion for 40 min. Chondrocytes were collected via centrifugation at 180g, and the remaining cartilage pieces were mixed with collagenase.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis

You

Feng

Zhou

et al. 2023

J. Agric. Food Chem.

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Osteoarthritis (OA) is a common joint disease, and studies have reported that the endoplasmic reticulum stress (ERS) in chondrocytes caused by the cartilage tissue damage could mediate the activation of Nod-like receptor protein 3 (NLRP3) inflammasomes through inositol-requiring enzyme 1 alpha (IRE1α) and thioredoxin interacting protein (TXNIP). Ginsenoside compound K (CK) has an inhibitory effect on IRE1α activation. However, the role of IRE1α-TXNIP and its interaction with CK are still unclear. In this study, we examined the role and mechanism of action of CK in OA. We found that CK ameliorated OA and ERS in IL-1β-treated chondrocytes and a monoiodoacetate-induced rat OA model. The effect of CK on inflammation, pyroptosis, and ERS was blocked by the ERS inducer tunicamycin. In conclusion, CK hindered OA progression by inhibiting the ERS-IRE1α-TXNIP-NLRP3 axis. Overall, our data indicate that CK could be useful in the treatment of OA and other chronic inflammatory diseases.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis

You

Feng

Zhou

et al. 2023

J. Agric. Food Chem.

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“…Another study suggested that moderate-intensity exercise can inhibit the inflammatory response of primary chondrocytes induced by IL-1β by increasing the level of 15-hydroxyeicosapetraenoic acid (15-HETE) in synovial fluid. The researchers found that 15-HETE could increase p-Akt levels and decrease the expression of MMP-3 and MMP-13 (Tian et al, 2021).…”

Section: Pi3k/akt Pathwaymentioning

confidence: 99%

Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation

Wan

Zhang

et al. 2021

Front. Physiol.

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Cells must alter their expression profiles and morphological characteristics but also reshape the extracellular matrix (ECM) to fulfill their functions throughout their lifespan. Matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinase (MMP) family, which can degrade multiple ECM components. MMP-3 can activate multiple pro-MMPs and thus initiates the MMP-mediated degradation reactions. In this review, we summarized the function of MMP-3 and discussed its effects on biological activities. From this point of view, we emphasized the positive and negative roles of MMP-3 in the pathogenesis of disease and cell differentiation, highlighting that MMP-3 is especially closely involved in the occurrence and development of osteoarthritis. Then, we discussed some pathways that were shown to regulate MMP-3. By writing this review, we hope to provide new topics of interest for researchers and attract more researchers to investigate MMP-3.

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“…15-HETE is a well-known anti-inflammatory molecule and was also able to inhibit IL-1β-induced inflammation in primary chondrocytes and increase p-Akt levels in vitro. Moreover, 15-HETE injection in knee OA alleviated cartilage damage through the inhibition of MMP-13 expression and the concomitant increase in COL2 expression in joint cartilage tissue [ 76 ].…”

Section: Physical Exercise As a Modulator Of Osteoarthritis Molecular Pathwaysmentioning

confidence: 99%

“…In this scenario, it should be noted that physical exercise could provide beneficial effects in OA according to several factors, including adherence to exercise regimens, frequency of exercise, and actual loading of the symptomatic compartment [ 76 , 78 ]. Nam et al [ 78 ] demonstrated that the extent of cartilage damage could play a key role in achieving the optimal effects of exercise.…”

Section: Physical Exercise As a Modulator Of Osteoarthritis Molecular Pathwaysmentioning

confidence: 99%

Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis

Sire

Marotta

Marinaro

et al. 2021

IJMS

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Osteoarthritis (OA) is a painful and disabling disease that affects millions of patients. Its etiology is largely unknown, but it is most likely multifactorial. OA pathogenesis involves the catabolism of the cartilage extracellular matrix and is supported by inflammatory and oxidative signaling pathways and marked epigenetic changes. To delay OA progression, a wide range of exercise programs and naturally derived compounds have been suggested. This literature review aims to analyze the main signaling pathways and the evidence about the synergistic effects of these two interventions to counter OA. The converging nutrigenomic and physiogenomic intervention could slow down and reduce the complex pathological features of OA. This review provides a comprehensive picture of a possible signaling approach for targeting OA molecular pathways, initiation, and progression.

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The anti-inflammatory effects of 15-HETE on osteoarthritis during treadmill exercise

Cited by 16 publications

References 36 publications

Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis

Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis

Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation

Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis

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