The anti-inflammatory effect of<i>triphala</i>in arthritic-induced rats

Kalaiselvan, Sowmiya; Rasool, Mahaboobkhan

doi:10.3109/13880209.2014.910237

Cited by 36 publications

(20 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of Triphala (100 mg/kg b wt, i.p.) restored the activities/levels of antioxidant (SOD~75.6%, CAT~62.7%, GPx~55.8%, GST~82.1%, and GSH~72.7%), and decreased the lipid peroxidation in the paw tissues of arthritic rats [68]. A study on another monosodium urate crystal-induced arthritis model showed support for Triphala exhibiting antioxidant properties and decreasing inflammation.…”

Section: In Vivo Studiesmentioning

confidence: 94%

Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala

Prasad

Srivastava

2020

Antioxidants

View full text Add to dashboard Cite

Oxidative stress, caused by the overproduction of free radicals, leads to the development of many chronic diseases including cancer. Free radicals are known to damage cellular biomolecules like lipids, proteins, and DNA that results in activation of multiple signaling pathways, growth factors, transcription factors, kinases, inflammatory and cell cycle regulatory molecules. Antioxidants, which are classified as exogenous and endogenous, are responsible for the removal of free radicals and consequently the reduction in oxidative stress-mediated diseases. Diet and medicinal herbs are the major source of antioxidants. Triphala, which is a traditional Ayurvedic formulation that has been used for centuries, has been shown to have immense potential to boost antioxidant activity. It scavenges free radicals, restores antioxidant enzymes and non-enzyme levels, and decreases lipid peroxidation. In addition, Triphala is revered as a chemopreventive, chemotherapeutic, immunomodulatory, and radioprotective agent. Accumulated evidence has revealed that Triphala modulates multiple cell signaling pathways including, ERK, MAPK, NF-κB, Akt, c-Myc, VEGFR, mTOR, tubulin, p53, cyclin D1, anti-apoptotic and pro-apoptotic proteins. The present review focuses on the comprehensive appraisal of Triphala in oxidative stress and cancer.

show abstract

Section: In Vivo Studiesmentioning

confidence: 94%

Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala

Prasad

Srivastava

2020

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Another study found that Triphala increased antioxidant levels and decreased lipid peroxidation in the tissues of arthritic rats. 69 …”

Section: Therapeutic Uses and Studiesmentioning

confidence: 99%

Therapeutic Uses ofTriphalain Ayurvedic Medicine

Peterson

Denniston

Chopra

2017

The Journal of Alternative and Complementary Medicine

245

156

View full text Add to dashboard Cite

Aim: The aim of this article is to review the current literature on the therapeutic uses and efficacy of Triphala. Herbal remedies are among the most ancient medicines used in traditional systems of healthcare such as Ayurveda. Triphala, a well-recognized and highly efficacious polyherbal Ayurvedic medicine consisting of fruits of the plant species Emblica officinalis (Amalaki), Terminalia bellerica (Bibhitaki), and Terminalia chebula (Haritaki), is a cornerstone of gastrointestinal and rejuvenative treatment.Methods: A search of the PubMed database was conducted.Results: In addition, numerous additional therapeutic uses described both in the Ayurvedic medical literature and anecdotally are being validated scientifically. In addition to laxative action, Triphala research has found the formula to be potentially effective for several clinical uses such as appetite stimulation, reduction of hyperacidity, antioxidant, anti-inflammatory, immunomodulating, antibacterial, antimutagenic, adaptogenic, hypoglycemic, antineoplastic, chemoprotective, and radioprotective effects, and prevention of dental caries. Polyphenols in Triphala modulate the human gut microbiome and thereby promote the growth of beneficial Bifidobacteria and Lactobacillus while inhibiting the growth of undesirable gut microbes. The bioactivity of Triphala is elicited by gut microbiota to generate a variety of anti-inflammatory compounds.Conclusions: This review summarizes recent data on pharmacological properties and clinical effects of Triphala while highlighting areas in need of additional investigation and clinical development.

show abstract

“…Our earlier reports showed that triphala extract had promising in vivo anti-inflammatory and anti-arthritic effects in adjuvant-induced arthritic rats (Kalaiselvan & Rasool 2015a). To explore anti-inflammatory molecular mechanisms, the present study focused on the inhibitory effects of the extract on pro-inflammatory cytokine, inflammatory enzyme, and inflammatory factor production by LPS-induced RAW 264.7, as well as their expression at the mRNA level.…”

Section: Discussionmentioning

confidence: 99%

Triphala herbal extract suppresses inflammatory responses in LPS-stimulated RAW 264.7 macrophages and adjuvant-induced arthritic rats via inhibition of NF-κB pathway

Kalaiselvan

Rasool

2016

Journal of Immunotoxicology

Self Cite

View full text Add to dashboard Cite

This study sought to explore the mechanism of anti-inflammatory effect of triphala in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in adjuvant-induced arthritic rats. In stimulated RAW 264.7 cells, triphala (100-300 μg/ml) significantly suppressed production of inflammatory mediators (e.g. TNFα, IL-1β, IL-6, MCP-1, VEGF, NO, PGE2), intracellular free radicals and release of lysosomal enzymes (e.g. acid phosphatase, β-galactosidase, N-acetyl glucosamindase and cathepsin D) in a dose-related manner. With triphala, mRNA levels of genes for pro-inflammatory TNFα, IL-1β, IL-6 and MCP-1, inflammatory iNOS and COX-2 enzymes and NF-κBp65 were down-regulated in the stimulated cells; in contrast, there was up-regulation of heme oxygenase-1 (HO-1) expression. Western blot analyses revealed that triphala suppressed the protein expression of NF-κB p65 and p-NF-κB p65 in the stimulated cells, which subsequently reduced over-expression of TNFα, IL-17, iNOS and COX-2 in a manner similar to that observed with BAY 11-7082, an IκB kinase inhibitor. Immunofluorescence analysis revealed inhibition of p-NF-κB p65 nuclear translocation and COX-2 protein expression caused by triphala. Consistent with these findings, the animal studies presented confirmed that triphala exhibited anti-inflammatory effects in a rat adjuvant-induced arthritis model by reducing of inflammatory mediator (e.g. IL-17, COX-2 and RANKL) expression via inhibition of NF-κB activation. Taken together, the results here demonstrated that triphala has potential anti-inflammatory applications that could be used for the treatment of inflammatory disorders, including rheumatoid arthritis.

show abstract

The anti-inflammatory effect oftriphalain arthritic-induced rats

Cited by 36 publications

References 46 publications

Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala

Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala

Therapeutic Uses ofTriphalain Ayurvedic Medicine

Triphala herbal extract suppresses inflammatory responses in LPS-stimulated RAW 264.7 macrophages and adjuvant-induced arthritic rats via inhibition of NF-κB pathway

Contact Info

Product

Resources

About