The Anti-inflammatory and Antipyretic Activities of Corchorus olitorius in Rats

Zunita, Z.; ., M.R. Sulaiman; Arifah, A. K.; Jais, Abdul Manan Mat; Somchit, M. N.; ., K. Kirisnaveni; ., D. Punnitharrani; ., M. Safarul; ., C.A. Fatimah; Johari, R

doi:10.3923/jpt.2006.139.146

Cited by 23 publications

(10 citation statements)

References 17 publications

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“…One approach to finding agents to prevent cancer cell proliferation and tumor formation is to study natural agents sourced from nature. In Asia, C. olitorius is a common leafy vegetable widely used in preparing dishes [ 34 ] and traditional medicine [ 13 , 14 ]. Pharmacological studies have shown that C. olitorius exhibits promising antioxidant and anti-inflammatory activities [ 35 ] beneficial for treating different cancers [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is considered by the Philippines Department of Science and Technology [ 12 ] as a functional food that provides health benefits beyond an essential nutrient function, such as for reducing the occurrence of lifestyle-related diseases including obesity, atherosclerosis, cardiovascular disease, diabetes, and cancer. Traditionally, C. olitorius has been considered a folk remedy for different illnesses such as diabetes, hypertension [ 13 ], aches, pains [ 14 ], infertility [ 15 ], pimples, wounds, boils, insect bites, and swellings. Original research articles have reported the different pharmacological properties of C. olitorius , which include antioxidant [ 16 ], anti-inflammatory [ 17 ], antihyperglycemic, and anticancer properties [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Anticancer Effects of the Corchorus olitorius Aqueous Extract and Its Bioactive Compounds on Human Cancer Cell Lines

et al. 2021

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Corchorus olitorius is a common, leafy vegetable locally known as “Saluyot” in the Philippines. Several studies have reported on its various pharmacological properties, such as antioxidant, anti-inflammatory, analgesic, and anticancer properties. However, little is known about its effects on angiogenesis. This study aimed to evaluate the anticancer properties, such as the antiproliferative, anti-angiogenic, and antitumor activities, of the C. olitorius aqueous extract (CO) and its bioactive compounds, chlorogenic acid (CGA) and isoquercetin (IQ), against human melanoma (A-375), gastric cancer (AGS), and pancreatic cancer (SUIT-2), using in vitro and in ovo biological assays. The detection and quantification of CGA and IQ in CO were achieved using LC-MS/MS analysis. The antiproliferative, anti-angiogenic, and antitumor activities of CO, CGA, and IQ against A-375, AGS, and SUIT-2 cancer cell lines were evaluated using MTT and CAM assays. CGA and IQ were confirmed to be present in CO. CO, CGA, and IQ significantly inhibited the proliferation of A-375, AGS, and SUIT-2 cancer cells in a dose-dependent manner after 48 h of treatment. Tumor angiogenesis (hemoglobin levels) of A-375 and AGS tumors was significantly inhibited by CO, CGA, IQ, and a CGA–IQ combination. The growth of implanted A-375 and AGS tumors was significantly reduced by CO, CGA, IQ, and a CGA–IQ combination, as measured in tumor weight. Our investigation provides new evidence to show that CO has promising anticancer effects on various types of human cancer cells. CO and its compounds are potential nutraceutical products that could be used for cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticancer Effects of the Corchorus olitorius Aqueous Extract and Its Bioactive Compounds on Human Cancer Cell Lines

et al. 2021

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“…Anticonvulsant, hepatobiliary, renal, antiesterogenic, hematological, antimalarial, and antihistaminic activities were well reviewed in Khan et al (3) as well as the related constituents. Anti-inflammatory and anti-pyretic effects of aqueous extract in rats were also demonstrated (2). Hydrophilic extract and lipophilic leaf extracts were comparatively evaluated for antioxidant capacities (4).…”

Section: Introduction Introductionmentioning

confidence: 99%

“…The common name for the edible vegetable is 'Molukhyia' . It has been reported to be used for the treatment of aches, dysentery, pectoral pains, fever, enteritis, and chronic cystitis in folklore medicine (2). Cardiovascular activities of the species of the genus Corchorus have extensively been studied, and attributed to cardiovascular glycosides and their derivatives (3).…”

Section: Introduction Introductionmentioning

confidence: 99%

Corchorus olitorius L. (Jute) leaf and seed extracts exerted high antibacterial activity against food and plant pathogenic bacteria

İşeri

Körpe

Şahin

et al. 2022

The EuroBiotech Journal

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Aim of this study was to comparatively evaluate antibacterial activities of methanol (MetOH), acetone (Ace), petroleum ether (PE) and aqueous (dw) leaf (L), root (R), and seed (S) extracts of Corchorus olitorius L. on both food- and plant-borne pathogens, with DPPH radical scavenging activities (DRSA), and quantitative and qualitative constituent analysis. Leaf PE has the highest strain susceptibility on both food- and plant-borne pathogens. Clavibacter michiganensis, Pseudomonas tomato, and Erwinia caratovora were susceptible to nearly all the leaf and seed extracts. Very low minimum inhibitory concentration (8-128 μg mL−1) and minimum bactericidal concentration (32-2048 μg mL−1) were determined for both leaf and seed extracts against C. michiganensis. Total phenolic contents were correlated to DRSA. The phenolic compounds tested were higher in the leaf MetOH, cholorogenic acid being the most abundant one. Palmitic acid was determined in leaf PE and seed PE extracts. Results presented here demonstrate high antibacterial activity of C. olitorius leaf seed extracts against phytopathogens for the first time, and provide the most comprehensive data on the antibacterial activity screening against food-borne pathogens. Considering limitations in plant disease control, antibacterial activities of these extracts would be important in plant disease control.

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“…These green leaves have also found usage in folk medicine as treatment of various ailments and diseases, and reportedly possess diuretic, demulcent, purgative, deobstruent, and tonic properties (Duke, 1983). The leaves are remedy for gastroenteritis, aches, and pains as well as fever in folk medicine (Duke, 1983;Zakaria et al, 2006). Furthermore, cold infusion of the leaf could be used to restore appetite and strength (Duke, 1983).…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation of jute leaf (Corchorus olitorius) modulates hepatic delta‐aminolevulinic acid dehydratase (δ‐ALAD) activity and oxidative status in high‐fat fed/low streptozotocin‐induced diabetic rats

et al. 2019

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Impaired liver function is associated with decreased hepatic delta‐aminolevulinic acid dehydratase (δ‐ALAD) activity in diabetes mellitus. Hence, this study described the effect of dietary jute leaf (Corchorus olitorius) on hepatic δ‐ALAD activity in high‐fat fed combined with low‐dose streptozotocin administered diabetic rats. Animals were fed diets containing 35% fat for 14 days prior to a single administration of low‐dose (35 mg/kg body weight) streptozotocin to induce diabetes. Thereafter, the animals were randomly placed in groups and fed 100 mg/g jute leaf‐supplemented diets for 30 days. The result showed that jute leaf supplementation significantly (p < 0.05) reversed the decreased hepatic δ‐ALAD activity, increased hepatic catalase and SOD activity accompanying the decrease in serum AST and AST activities. This finding suggests that restoration of hepatic δ‐ALAD activity, modulation of hepatic function biomarkers, and increase in antioxidant status could be possible underlying events mediating the hepatoprotective effect of jute leaf in diabetic conditions. Practical applications Decrease in hepatic δ‐ALAD activity has been associated with diabetes‐induced hepatotoxicity arising from prolonged and uncontrolled hyperglycemia. Therefore, increased δ‐ALAD activity represents improved hepatic function in diabetic situations. Antidiabetic properties of jute leaf have been demonstrated but information on its effect on hepatic δ‐ALAD is lacking. Thus, this study revealed that dietary supplementation of jute leaf restored hepatic δ‐ALAD activities and improved liver antioxidant status in diabetic rats which is an indication of its hepatoprotective properties.

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The Anti-inflammatory and Antipyretic Activities of Corchorus olitorius in Rats

Cited by 23 publications

References 17 publications

Anticancer Effects of the Corchorus olitorius Aqueous Extract and Its Bioactive Compounds on Human Cancer Cell Lines

Anticancer Effects of the Corchorus olitorius Aqueous Extract and Its Bioactive Compounds on Human Cancer Cell Lines

Corchorus olitorius L. (Jute) leaf and seed extracts exerted high antibacterial activity against food and plant pathogenic bacteria

Dietary supplementation of jute leaf (Corchorus olitorius) modulates hepatic delta‐aminolevulinic acid dehydratase (δ‐ALAD) activity and oxidative status in high‐fat fed/low streptozotocin‐induced diabetic rats

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