The Anti‐inflammatory Activiy of Metal Complexes of Heterocyclic Thiosemicarbazones, 2-Substituted Pyridine N-Oxides and 2-Pyridylthioureas

Abstract

The thiosemicarbazones and their related metal complexes were shown to be potent anti-inflammatory agents in rodents at 8 mg kg-*. They were effective in blocking induced edema and endotoxic shock while blocking both local and central pain processes. The ability of the agents to function as anti-inflammatory agents is multifold. First, Tumor Necrosis Factor-alpha (TNFar) and Interleukin-1 (IL-1) release was markedly reduced by the agents. Second, high-affinity receptor binding on fibroblasts of TNFa and IL-1 was significantly inhibited. Third, cellular events, e.g. lysosomal enzymes of specific cells, such as macrophages, were inhibited and prostaglandin cyclo-oxygenase and leukotriene 5'-lipoxygenase enzymic synthetic rates were significantly reduced, which should cause an overall reduction of the inflammatory process.

Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents

“…Due to the strong reactivity of the hydrazine nitrogen (C=N) and thioketone (C=S) groups, TCS compounds represent a versatile class of Schiff bases and are important in medicinal chemistry [ 14 ]. Recently, there has been a concentrated research on Schiff bases and their complexes due to their range of biological activity including antifungal, antibacterial, antimalarial, antiviral, anticancer, anti-inflammatory, sedative-hypnotic, antidepressant, analgesic, cytotoxic, anticonvulsant [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”