The Anti-inflammatory Actions of Tilorone Hydrochloride

Megel, Herbert; Raychaudhuri, A.; Shemano, Irving; Beaver, Thomas H.; Thomas, Lewis

doi:10.3181/00379727-149-38749

Cited by 27 publications

(11 citation statements)

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“…This was confirmed in a rat paw model of this paper as the non-steroids were much less effective on passive Arthus than on carrageenin oedema. Whereas tilorone was effective on the both inflammations with a specific time-lag as implied with a report of Megel et al [3]. These results indicate that tilorone is an antiinflammatory agent which possess a different pharmacological property from the non-steroidal antiinflammatory medicaments and of interest is the mode of action.…”

Section: Discussionsupporting

confidence: 49%

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Dissociation between antiinflammatory action of tilorone and its interferon inducing activity

Hiyama

Kuriyama

1991

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A relation between antiinflammatory action of tilorone and its interferon inducing activity was studied in rats. Tilorone (20-100 mg/kg, p.o.) was dose-dependently effective on both carrageenin oedema and passive Arthus, suggesting that the pharmacological property of the compound is different from nonsteroidal antiinflammatory medicaments which were weak inhibitors of passive Arthus. The antiinflammatory action of tilorone had a time-lag and priming with tilorone 24 hrs prior to inflammatory insult was required to demonstrate maximal efficacy. This time course change was similar to that of serum interferon level. In addition, a high correlation was observed between the antiinflammatory activity and the serum interferon level. However, the antiinflammatory action was scarcely affected even if the serum interferon level was remarkably lowered by treatment of an inhibitor of protein biosynthesis, cycloheximide. These findings suggested that the antiinflammatory action of tilorone could be dissociated from its interferon inducing activity.

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Section: Discussionsupporting

confidence: 49%

“…It has also been reported to be effective on both allergic [3][4][5] and non-allergic [3] inflammations. Of interest is that the interferon inducer produces such antiinflammatory activities.…”

Section: Introductionmentioning

confidence: 99%

Dissociation between antiinflammatory action of tilorone and its interferon inducing activity

Hiyama

Kuriyama

1991

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“…Interferon-inducing agents like ploy TIC, tilorone and statolon have shown to elicit significant anti-inflammatory activity (7)(8)(9)(10)(11). In addition, rheumatoid arthritic patients receiving interferon therapy showed significant improvement in grip-strength and motility of joints (12).…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity of 6mfa, a Compound Obtained From Fungus Aspergillus Ochraceus

Naik

Deshmukh

Raman

1986

JJMSB

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“…The minimally effective dose of orally administered hydrocortisone (data not shown) in this assay was in the range of 3 to 9 mg/kg. Other nonsteroidal anti-inflammatory drugs (e.g., phenylbutazone, indomethacin, ibuprofen, naproxen) have generally been found, except at toxic doses, to be ineffective as inhibitors of reversed passive Arthus reactions in rats [39][40][41][42][43].…”

Section: (Iv) Reversed Passive Cutaneous Arthus Reactionmentioning

confidence: 99%

2,6-Di-tert-butyl-4-(2′-thenoyl)phenol(R-830): A novel nonsteroidal anti-inflammatory agent with antioxidant properties

Moore¹,

Swingle²

1982

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R-830, a di-tert-butylphenol, has been shown to be anti-inflammatory in a number of animal models. These include conventional systems such as carrageenan-induced edema and adjuvant arthritis of the rat and ultraviolet-induced erythema in the guinea pig in which the acidic nonsteroidal anti-inflammatory drugs (e.g., indomethacin) are effective. The anti-inflammatory activity of R-830 has also been demonstrated in other models (e.g., graft vs. host reaction and reversed passive cutaneous Arthus reaction in the rat, contact sensitivity in the mouse) in which the acidic nonsteroidal drugs are not effective. In vitro, R-830 inhibits guinea pig lung lipoxygenase and bovine seminal vesicle cyclo-oxygenase. The antioxidant properties of R-830 were demonstrated in two in vitro systems. We speculate that the antioxidant activity of this molecule might be related to its unusual profile of pharmacological activity.

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The Anti-inflammatory Actions of Tilorone Hydrochloride

Cited by 27 publications

References 0 publications

Dissociation between antiinflammatory action of tilorone and its interferon inducing activity

Dissociation between antiinflammatory action of tilorone and its interferon inducing activity

Anti-Inflammatory Activity of 6mfa, a Compound Obtained From Fungus Aspergillus Ochraceus

2,6-Di-tert-butyl-4-(2′-thenoyl)phenol(R-830): A novel nonsteroidal anti-inflammatory agent with antioxidant properties

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