The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells

Ho, Feng-Ming; Kang, Hao-Cheng; Lee, Sho-Tone; Chao, Yee; Chen, You-Ci; Huang, Le-Tian; Lin, Wan-Wan

doi:10.1016/j.bcp.2007.04.008

Cited by 41 publications

(18 citation statements)

References 44 publications

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“…In accordance with this, HO-1 suppresses SMC proliferation and migration, and NQO1 and SQSTM1 suppress proliferation of VSMCs [149,150,64,65]. In addition, a carbazole analogue, LCY-2-CHO, shows anti-inflammatory actions through the Nrf2/HO-1 pathway in rat aortic VSMCs, indicating that Nrf2 may protect against atherosclerosis through suppression of VSMC migration, proliferation and inflammation [151].…”

Section: Role Of Nrf2 In Vascular Smooth Muscle Cellsmentioning

confidence: 70%

Role of Nrf2 in the pathogenesis of atherosclerosis

Mimura

Itoh

2015

Free Radical Biology and Medicine

123

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Section: Role Of Nrf2 In Vascular Smooth Muscle Cellsmentioning

confidence: 70%

Role of Nrf2 in the pathogenesis of atherosclerosis

Mimura

Itoh

2015

Free Radical Biology and Medicine

123

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“…69 -71 These intracellular pathways have also been shown to play a significant role in smooth muscle cells, mast cells, and endothelial cells. [72][73][74] Hence, the expression of PGE 2 -synthesizing enzymes is most likely regulated by a complex network of cytokines and signal transduction pathways, as well as by cross-talk interactions among cells.…”

Section: Discussionmentioning

confidence: 99%

Expression of Prostaglandin E Synthases in Periodontitis

Båge

Kats

Lopez

et al. 2011

The American Journal of Pathology

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The inflammatory mediator prostaglandin E 2 (PGE 2 ) is implicated in the pathogenesis of chronic inflammatory diseases including periodontitis; it is synthesized by cyclooxygenases (COX) and the prostaglandin E synthases mPGES-1, mPGES-2, and cPGES. The distribution of PGES in gingival tissue of patients with periodontitis and the contribution of these enzymes to inflammationinduced PGE 2 synthesis in different cell types was investigated. In gingival biopsies, positive staining for PGES was observed in fibroblasts and endothelial, smooth muscle, epithelial, and immune cells. To further explore the contribution of PGES to inflammation-induced PGE 2 production, in vitro cell culture experiments were performed using fibroblasts and endothelial, smooth muscle, and mast cells. All cell types expressed PGES and COX-2, resulting in basal levels of PGE 2 synthesis. In response to tumor necrosis factor (TNF-␣), IL-1␤, and cocultured lymphocytes, however, mPGES-1 and COX-2 protein expression increased in fibroblasts and smooth muscle cells, accompanied by increased PGE 2 , whereas mPGES-2 and cPGES were unaffected. In endothelial cells, TNF-␣ increased PGE 2 production only via COX-2 expression, whereas in mast cells the cytokines did not affect PGE 2 enzyme expression or PGE 2 production. Furthermore, PGE 2 production was diminished in gingival fibroblasts derived from mPGES-1 knockout mice, compared with wild-type fibroblasts. These results suggest that fibroblasts and smooth muscle cells are important sources of mPGES-1, which may contribute to increased PGE 2 production in the inflammatory condition periodontitis.

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“…Widespread interests of chemists have been attracted to these structures due to their biological activities and potential applications as pharmacological agents [3]. A large number of natural and synthetic carbazole derivatives have been reported to exhibit diverse biological activities such as antimicrobial [4e8], antitumor [9e11], antiviral [12], anti-inflammatory [13], antimalarial [14], antidiarrhoeal [15] and other biological properties such as immunosuppression [16], neuroprotection [17] and pancreatic lipase inhibition [18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid

Wang

2010

European Journal of Medicinal Chemistry

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The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells

Cited by 41 publications

References 44 publications

Role of Nrf2 in the pathogenesis of atherosclerosis

Role of Nrf2 in the pathogenesis of atherosclerosis

Expression of Prostaglandin E Synthases in Periodontitis

Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid

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