The Anti-Genotoxic Activity of Wastewaters Produced after Water-Steam Distillation of Bulgarian Rosa damascena Mill. and Rosa alba L. Essential Oils

Gateva, Svetla; Jovtchev, Gabriele; Angelova, Tsveta; Dobreva, Ana; Mileva, Milka

doi:10.3390/life12030455

Cited by 10 publications

(6 citation statements)

References 49 publications

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“…Wastewaters from rose oil production are phytocomplexes, rich in water-soluble components, meaning that their biological activities are due to the overall action (complementary or antagonistic) of all their ingredients. What they have in common is that the four wastewaters can serve as important raw materials for producing cytotoxically and genotoxically safe commercial products [49]. The obtained results allow us to view R. gallica and R. as potential antiherpes agents.…”

Section: Discussionmentioning

confidence: 76%

In Vitro Study of the Biological Potential of Wastewater Obtained after the Distillation of Four Bulgarian Oil-Bearing Roses

Ilieva

Dimitrova

Georgieva

et al. 2022

Plants

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The wastewater after rose oil distillation is usually discharged into the drainage systems and it represents a serious environmental problem. While being rich in polyphenols, which have beneficial biological activity and application in the pharmaceutical industry, limited research has been carried out about the biological activity of the specific wastewaters per se. Wastewaters after distillation of the four Bulgarian oil-bearing roses Rosa damascena Mill., R. alba L., R. centifolia L., and R. gallica L. exerted significant antioxidant activity and good antiherpes simplex virus type-1 (HSV-1) activity while maintaining a good toxicological safety profile (low cytotoxic effect) towards normal cell lines. More precisely, the non-tumorigenic cells were a human (HEK-293 embryonic kidney cells) and a mouse cell line (CCL-1 fibroblasts, which are recommended as a standard for cytotoxicity evaluation in Annex C of ISO 10993-5). The concentrations that achieved antioxidant and radical scavenging effects (0.04–0.92% v/v) were much lower than most of the maximum tolerated concentrations for the tissue culture cells (0.2–3.4% v/v). The wastewaters had a weak antiproliferative effect against Staphylococcus aureus. None of the wastewaters had activity against Gram-negative bacteria or a bactericidal or antifungal effect. We can conclude that these four species, which are the most preferred species worldwide for producing high-quality rose oil, have the potential to be developed as promising antioxidant and antiherpesvirus nutraceuticals.

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Section: Discussionmentioning

confidence: 76%

In Vitro Study of the Biological Potential of Wastewater Obtained after the Distillation of Four Bulgarian Oil-Bearing Roses

Ilieva

Dimitrova

Georgieva

et al. 2022

Plants

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“…The stable anti-E. coli activity may possess a practical significance, due to the proven safety of WWR. In our previous study, we investigated the cytotoxic/genotoxic and anti-cytotoxic/anti-genotoxic potential of these products in different experimental treatment regimens [32]. The results obtained showed that the genotoxic activity of the distillation effluents of R. alba and R. damascena was low.…”

Section: In Vitro Assessment Of Biological Activity Of L Plantarum Ac...mentioning

confidence: 99%

“…Both types of waste products exhibited anti-genotoxic effects against N-methyl-N0-nitro-N-nitrosoguanidine as a direct mutagen, and cytoprotective/genoprotective effects to promote a reduction in DNA damage. As can be seen, these effluents fall into the category of bio-pollutants, but they contain valuable bioactive compounds and exhibit interesting biological properties [32]. We related the exhibited biological activities to the total flavonoid content of the two waste products-tannins in R. damascena were 1.61 ± 0.05 mg/mL, and in R. alba tannins were 2.16 ± 0.35, flavonoids 1.14 ± 0.01 mg/mL and 1.01 ± 0.01 mg/mL, and total polyphenols 7.2 ± 0.2 and 7.6 ± 0.3 mg/mL, respectively [18].…”

Section: In Vitro Assessment Of Biological Activity Of L Plantarum Ac...mentioning

confidence: 99%

Postbiotics Production of Candidate-Probiotic Lactiplantibacillus plantarum AC131 with Renewable Bio Resources

Danova,

Yankov,

Dobreva

et al. 2023

Life

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Lactiplantibacillus plantarum is a versatile specie, well known as a producer of lactic acid (LA) and other metabolites with biotechnological significance. The present work characterizes growth and lactic acid production of the candidate-probiotic strain L. plantarum AC131, from Bulgarian white brined cheeses. Different nutritional media with ingredients from renewable resources—reduced sugars from dried distillers’ grains with soluble (DDGS) and waste waters from the water-vapor distillation of Bulgarian Rosa alba L. and Rosa damascena Mill. essential oil—were assessed. The results obtained showed significant LA production (up to 95% conversion) in modified MRS broth with reducing sugars from DDGS hydrolysates. The addition of R. alba L. and R. damascena Mill. distillation effluents stimulated the growth and biological activity of postbiotics produced by L. plantarum AC131. In both experimental approaches, a statistically significant inhibition (from 20 to 60%) of E. coli HB 101 growth was found during 24 h exposure and a variable effect on the biofilm formed. In conclusion, reducing sugars from DDGS hydrolysates can be successfully used as a carbon source for lactic acid production. In the case of fermentation without pH control, the process is product inhibited, while with pH control, nearly full conversion was achieved. Postbiotics produced during the process of fermentation showed a variety of biological activity and inhibitory effects on the growth of Escherichia coli HB 101.

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“…Bulgaria and Turkey are globally known for the rose oil (Slavov et al, 2021). The tiny wield of the rose oil production lead to massive quantities of by-products (Gateva et al, 2022). Previous researches evaluated the composition of the ethanol extract dried rose (Ro sa Damascena Mill.)…”

Section: Introductionmentioning

confidence: 99%

Color dynamics of cooked sausages after nitrite reduction and incorporation of biologically active substances

Kolev

Vlahova-Vangelova

Balev

et al. 2022

jour

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In most cases, the color of meat products is the factor influencing consumer choice. It’s formation and preservation is the highest priority. Sodium nitrite is used for fixation of the pleasant pink-red color, but also has a negative image from the consumers oriented towards clean label products. The valorization of rose oil-industry by-products by their incorporation in foods as natural additives is growing research area. The formulated cooked sausage recipes, contain blend of three biologically active substances (BAS) and different level of sodium nitrite reductions: AN100, AN75, AN50, AN25, AN0 and control - C. Color attributes CIE L*, a*, b* were assessed during 14 days of chilled storage (0-4 °C) and their changes in dynamics were evaluated every 10 min for an hour at air exposure. The incorporation of the inhibit the oxidation of meat pigments during the chilled storage and slowed down the fading of the pinkred color of the cross-cut surface during the 60 min of air exposure. The sausages produced with up to 50 % nitrite reduction and the blend of three BAS have lower lightness (L*), higher intensity of the red color (a*) and lower yellowness (b*) of the cross-cut surface in comparison to the control.

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The Anti-Genotoxic Activity of Wastewaters Produced after Water-Steam Distillation of Bulgarian Rosa damascena Mill. and Rosa alba L. Essential Oils

Cited by 10 publications

References 49 publications

In Vitro Study of the Biological Potential of Wastewater Obtained after the Distillation of Four Bulgarian Oil-Bearing Roses

In Vitro Study of the Biological Potential of Wastewater Obtained after the Distillation of Four Bulgarian Oil-Bearing Roses

Postbiotics Production of Candidate-Probiotic Lactiplantibacillus plantarum AC131 with Renewable Bio Resources

Color dynamics of cooked sausages after nitrite reduction and incorporation of biologically active substances

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